• Lymphadenopathy and worm infestation in children: the action algorithm
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Lymphadenopathy and worm infestation in children: the action algorithm

Modern Pediatrics. Ukraine. (2022). 8(128): 90-97. doi 10.15574/SP.2022.128.90
Nykytyuk S. O.1, Tsymbalyuk I. M.2, Dorozhovska Kh. I.1, Levenets S. S.1, Voroncova T. O.1, Dollinna M. V.2
1I.Ya. Gorbachevsky Ternopil National Medical University, Ukraine
2KNE «Ternopil Regional Children’s Clinical Hospital», Ukraine

For citation: Nykytyuk SO, Tsymbalyuk IM, Dorozhovska KhI, Levenets SS, Voroncova TO, Dollinna MV. (2022). Lymphadenopathy and worm infestation in children: the action algorithm. Modern Pediatrics. Ukraine. 8(128): 90-97. doi 10.15574/SP.2022.128.90.
Article received: Nov 11, 2022. Accepted for publication: Dec 20, 2022.

Fever is a common complaint in children with lymphadenopathy. Reactive lymphadenopathy is defined as the presence of one or more lymph nodes with a diameter of more than 1.5-2.0 cm. A thorough diagnosis of lymphadenitis accompanied by hyperthermic syndrome is necessary.
Purpose – is to determine the diagnostic algorithm of actions based on the example of a clinical case of fever of unclear origin.
Clinical case. The peculiarity of this case is a prolonged hyperthermic syndrome with lymphadenitis against the background of helminthic invasion (toxocarosis). During her stay in the hospital, the girl’s condition was serious due to hyperthermic syndrome and lymphadenopathy. The diagnostic algorithm for this condition in children is proposed.
During the examination, a diagnosis of Reactive cervical lymphadenopathy of infectious-allergic genesis; concomitant – «Parasitic invasion is mixed (toxocariasis, ascariasis). Fever» was established. The child’s condition upon admission was severe, due to intoxication and hyperthermic syndrome. The treatment was effective, the patient’s condition improved during the hospitalization. But establishing a diagnosis required the cooperation of doctors of many specialties and a large number of additional examinations.
Conclusions. Therefore, it is necessary to form the alertness of pediatricians to toxocarosis and increase the level of knowledge about the correct diagnostic algorithm in such cases. Informing health care professionals about such lymphadenopathy and helminthic infestation in children should help practitioners distinguish them from febrile reactions or other conditions and improve treatment outcomes.
The research was carried out in accordance with the principles of the Declaration of Helsinki. Informed consent of the child’s parents was obtained for the research.
No conflict of interests was declared by the authors.
Keywords: child, lymphadenitis, toxocarosis, diagnostic algorithm, indications for treatment.
REFERENCES
1. Aguiar-Santos AM, Andrade LD, Medeiros Z, Chieffi PP, Lescano SZ, Perez EP. (2004). Human toxocariasis: Frequency of anti-Toxocara antibodies in children and adolescents from an outpatient clinic for lymphatic filariasis in Recife, Northeast Brazil Rev. Inst. Med. Trop. S. Paulo. 46 (2): 81-85. https://doi.org/10.1590/S0036-46652004000200005; PMid:15141276

2. Antoon JW, Potisek NM, Lohr JA. (2015, Sep). Pediatric Fever of Unknown Origin Pediatr Rev. 36 (9): 380-90; quiz 391. https://doi.org/10.1542/pir.36-9-380; PMid:26330472

3. Carvalho EAA, Rocha RL. (2011, Mar-Apr). Toxocariasis: visceral larva migrans in children J Pediatr (Rio J). 87 (2): 100-110. https://doi.org/10.2223/JPED.2074; PMid:21503372

4. Chang SSY, Xiong M, How ChH, Lee DM. (2020). An approach to cervical lymphadenopathy in children, Singapore Med J. 61 (11): 569-577. https://doi.org/10.11622/smedj.2020151; PMid:33283242 PMCid:PMC8040913

5. Chow A, Robinson JL. (2011). Fever of unknown origin in children: a systematic review. World J Pediatr. 7: 5-10. https://doi.org/10.1007/s12519-011-0240-5; PMid:21191771

6. Cleri DJ, Ricketti AJ, Vernaleo JR. (2007, Dec). Fever of Unknown Origin Due to Zoonoses. Infect Dis Clin North Am. 21 (4): 963-996. https://doi.org/10.1016/j.idc.2007.08.009; PMid:18061085 PMCid:PMC7135411

7. Defendi GL. (2020, Dec 21). Pediatric Toxocariasis. Pediatrics: General Medicine. URL: https://emedicine.medscape.com/article/999850-overview.

8. Deosthali A, Donches K, Del Vecchio M, Aronoff S. (2019). Etiologies of pediatric cervical lymphadenopathy: a systematic review of 2687 subjects. Glob Pediatr Health. 6: 2333794X19865440. Published online 2019 Jul 27. https://doi.org/10.1177/2333794X19865440; PMid:31384630 PMCid:PMC6661788

9. Despommier D. (2003, Apr). Toxocariasis: Clinical Aspects, Epidemiology, Medical Ecology, and Molecular Aspects. Clin Microbiol Rev. 16 (2): 265-272. https://doi.org/10.1128/CMR.16.2.265-272.2003; PMid:12692098 PMCid:PMC153144

10. Efstathiou SP, Pefanis AV, Tsiakou AG et al. (2010). Fever of unknown origin: discrimination between infectious and non-infectious causes. Eur J Intern Med. 21: 137-143. https://doi.org/10.1016/j.ejim.2009.11.006; PMid:20206887

11. Elefant GR, Shimizu SH, Sanchez MCA, Jacob CMA, Ferreira AW. (2006). A serological follow-up of toxocarosis patients after chemotherapy based on the detection of IgG, IgA, and IgE antibodies by enzyme-linked immunosorbent assay. J Clin Lab Anal. 20: 164-172. https://doi.org/10.1002/jcla.20126; PMid:16874812 PMCid:PMC6807646

12. Espinoza YA, Huapaya PH, Roldani WH, Jimenezi S, Arce Z, Lopez E. (2008). Clinical and serological evidence of Toxocara infection in school children from Morrope district, Lambayeque, Peru. Rev Inst Med Trop S. Paulo. 50 (2): 101-105. https://doi.org/10.1590/S0036-46652008000200007; PMid:18488089

13. Friedmann AM. (2008, Feb). Evaluation and management of lymphadenopathy in children. Pediatr Rev. 29 (2): 53-60. https://doi.org/10.1542/pir.29-2-53; PMid:18245301

14. Fusco FM, Pisapia R et al. (2019, Jul 22). Fever of unknown origin (FUO): which are the factors influencing the final diagnosis? A 2005-2015 systematic review. BMC Infectious Diseases. 19: 653. https://doi.org/10.1186/s12879-019-4285-8; PMid:31331269 PMCid:PMC6647059

15. Gaddey HL, Riegel AM. (2016). Unexplained Lymphadenopathy: Evaluation and Differential Diagnosis, Am Fam Physician. 94 (11): 896-903.

16. Jackson DL. (2018, Apr). Evaluation and management of pediatric neck masses. Physician Assist Clin. 3 (2): 245-269. https://doi.org/10.1016/j.cpha.2017.12.003; PMid:32289087 PMCid:PMC7140292

17. Kim H-B, Seo J-W, Lee J-H, Choi B-S, Park S-G. (2017, May). Evaluation of the prevalence and clinical impact of toxocariasis in patients with eosinophilia of unknown origin. Korean J Intern Med. 32 (3): 523-529. https://doi.org/10.3904/kjim.2014.270; PMid:28352060 PMCid:PMC5432784

18. Kimberlin DW, Barnett ED, Lynfield R, Sawyer MH. (2021). Toxocariasis. Red Book: 2021-2024. Report of the Committee on Infectious Diseases, Committee on Infectious Diseases. 32nd Edition. American Academy of Pediatrics. https://doi.org/10.1542/9781610025225

19. King D, Ramachandra J, Yeomanson D. (2014, Jun). Lymphadenopathy in children: refer or reassure? Arch Dis Child Educ Pract Ed. 99 (3): 101-110. Epub 2014 Jan 2. https://doi.org/10.1136/archdischild-2013-304443; PMid:24385291

20. Kroten A, Toczylowski K, Oldak E, Sulik A. (2018). Toxocarosis in children: poor hygiene habits and contact with dogs is related to longer treatment. Parasitology Research. 117: 1513-1519. https://doi.org/10.1007/s00436-018-5833-7; PMid:29557502 PMCid:PMC5915510

21. Lang S, Kansy B. (2014, Dec 1). Cervical lymph node diseases in children. GMS Curr Top Otorhinolaryngol Head Neck Surg. 13: Doc08. doi: 10.3205/cto000111. eCollection 2014.

22. Magnaval J-F, Glickman LT, Dorchies Ph, Morassin B. (2001, Mar). Highlights of human toxocariasis. Korean J Parasitol. 39 (1): 1-11. https://doi.org/10.3347/kjp.2001.39.1.1; PMid:11301585 PMCid:PMC2721060

23. Martín UO, Machuca PB, Demonte MA, Contini L. (2008). Analysis of children with a presumptive diagnosis of toxocariasis in Santa Fe, Argentina. Medicina (B Aires). 68 (5): 353-357.

24. Mazur-Melewska K, Mania A, Figlerowicz M, Kemnitz P, Służewski W et al. (2012). The influence of age on a clinical presentation of Toxocara spp. infection in children. Environ Med. 19 (2): 233-236.

25. Pawłowski Z. (2001, Dec). Toxocariasis in humans. Clinical expression and treatment dilemma. J Helminthol. 75 (4): 299-305. https://doi.org/10.1017/S0022149X01000464; PMid:11818044

26. Rajasekaran K, Krakovitz P. (2013, Aug). Enlarged neck lymph nodes in children. Pediatr Clin North Am. 60 (4): 923-936. https://doi.org/10.1016/j.pcl.2013.04.005; PMid:23905828

27. Rigante D, Esposit S. (2013). A roadmap for fever of unknown origin in children. Int J Immunopathol Pharmacol. 26 (2): 315-326. https://doi.org/10.1177/039463201302600205; PMid:23755747

28. Rosenberg TL, Nolder AR. (2014, Oct). Pediatric cervical lymphadenopathy. Otolaryngol Clin North Am. 47 (5): 721-731. https://doi.org/10.1016/j.otc.2014.06.012; PMid:25213279

29. Turrientes M-C, de Ayala AP, Norman F, Navarro M, Perez-Molina J-A et al. (2011). Visceral larva migrans in immigrants from latin america. Emerg Infect Dis. 17: 1263-1265. https://doi.org/10.3201/eid1707.101204; PMid:21762582 PMCid:PMC3381370

30. Weinstock MS, Patel NA, Smith LP. (2018). Pediatric Cervical Lymphadenopathy. Pediatr Rev. 39 (9): 433-443. https://doi.org/10.1542/pir.2017-0249; PMid:30171054

31. Wiśniewska-Ligier M, Woźniakowska-Gęsicka T, Sobolewska-Dryjańska J, Markiewicz-Jóźwiak A, Wieczorek M. (2012). Analysis of the course and treatment of toxocarosis in children-a long-term observation. Parasitol Res. 110: 2363-2371. https://doi.org/10.1007/s00436-011-2772-y; PMid:22205349 PMCid:PMC3362726

32. Woodhall DM, Garcia AP, Shapiro CA, Wray ShL, Shane AL, Mani ChS et al. (2017, Oct 11). Assessment of U.S. Pediatrician Knowledge of Toxocariasis. Am J Trop Med Hyg. 97 (4): 1243-1246. https://doi.org/10.4269/ajtmh.17-0232; PMid:28820703 PMCid:PMC5637614