Modern pediatrics. Ukraine. 2019.4(100):43-52; doi 10.15574/SP.2019.100.43

Dobryanskyy D. O., Menshykova A. O., Borysuk O. P.
Danylo Halytsky Lviv National Medical University, Ukraine

For citation: Dobryanskyy DO, Menshykova AO, Borysuk OP. (2019). Long-term outcomes of bronchopulmonary dysplasia in preterm infants. Modern pediatrics. Ukraine. 4(100): 43-52. doi 10.15574/SP.2019.100.43
Article received: Feb 01, 2019. Accepted for publication: Apr 30, 2019.

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Content

Bronchopulmonary dysplasia (BPD) remains an important cause of morbidity and mortality of very preterm infants significantly affecting their outcomes. This disease is associated with increased morbidity and developmental disorders not only in early childhood but also at school age, and significantly affects the quality of life of sick children, their families and society. Despite the development and current achievements of Perinatology, the incidence of BPD in developed countries has increased over the past decades. During the past 40 years, definitions, pathogenesis, pathophysiology, clinical course, diagnostic criteria, as well as approaches to the prevention and treatment of this disease have changed significantly. At the same time, only a few safe and effective interventions are known that can prevent development or effectively treat BPD. Nowadays, there is evidence that in adults with history of BPD, the lung function not only fails to reach its age maximum, but also deteriorates faster, identifying a higher risk of chronic obstructive pulmonary disease or even death. That is why prevention of BPD is one of the undisputed priorities in the health care, which is becoming increasingly relevant due to the important potential role of this disease in the pathogenesis of chronic obstructive pulmonary disease.

No conflict of interest was declared by the authors

Key words: bronchopulmonary dysplasia, definition, outcomes, pathogenetic mechanisms, prevention, management, prematurity.

REFERENCES

1. Besh LV, Tkachenko SK, Matsyura OI. (2011). Remote consequences of bronchopulmonary dysplasia in early4aged children: terminological, diagnostics and treatment problems. Pediatriia, Akusherstvo ta Hinekolohiia. 1: 40–3.

2. Borysiuk OP, Dobryanskyy DO, Salabay ZV, Detsyk OY, Novikova OV, Dobush OV, et al. (2011). Clinical preconditions for bronchopulmonary dysplasia development in very preterm newborns. Problemy Klinichnoi Pediatrii. 4(14): 24–33.

3. Ambalavanan N, Carlo WA, McDonald SA, Yao Q, Das A, Higgins RD; Generic Database and Follow-up Subcommittees of the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. (2011). Identification of extremely premature infants at high risk of rehospitalization. Pediatrics. 128(5): e1216–25. https://doi.org/10.1542/peds.2011-1142; PMid:22007016 PMCid:PMC3208965

4. Anderson PJ, Doyle LW. (2006). Neurodevelopmental outcome of bronchopulmonary dysplasia. Semin Perinatol. 30(4): 227–32. https://doi.org/10.1053/j.semperi.2006.05.010; PMid:16860163

5. Baraldi E, Bonetto G, Zacchello F, Filippone M. (2005). Low exhaled nitric oxide in schoolage children with bronchopulmonary dysplasia and airflow limitation. Am J Respir Crit Care Med. 171(1): 68–72. https://doi.org/10.1164/rccm.200403-298OC; PMid:15477497

6. Bhandari A, Panitch H. (2018). An update on the post-NICU discharge management of bronchopulmonary dysplasia. Semin Perinatol. 42(7): 471–477. https://doi.org/10.1053/j.semperi.2018.09.011; PMid:30487070

7. Bohm B, Katz-Salamon M. (2003). Cognitive development at 5.5 years of children with chronic lung disease of prematurity. Arch Dis Child Fetal Neonatal Ed. 88(2): F101-5. https://doi.org/10.1136/fn.88.2.F101; PMid:12598496 PMCid:PMC1721516

8. Chye JK, Gray PH. (1995). Rehospitalization and growth of infants with bronchopulmonary dysplasia: a matched control study. J Paediatr Child Health. 31(2): 105–11. https://doi.org/10.1111/j.1440-1754.1995.tb00756.x; PMid:7794609

9. DeMauro SB, D'Agostino JA, Bann C, Bernbaum J, Gerdes M, Bell EF et al. (2014). Developmental outcomes of very preterm infants with tracheostomies. J Pediatr. 164(6): 1303–10. https://doi.org/10.1016/j.jpeds.2013.12.014; PMid:24472229 PMCid:PMC4035374

10. Dewey D, Creighton DE, Heath JA, Wilson BN, Anseeuw4Deeks D, Crawford SG et al. (2011). Assessment of developmental coordination disorder in children born with extremely low birth weights. Dev Neuropsychol. 36(1): 42–56.

11. Doyle LW, Victorian Infant Collaborative Study Group. (2006). Respiratory function at age 8–9 years in extremely low birthweight/very preterm children born in Victoria in 1991—1992. Pediatr Pulmonol. 41(6): 570–6. https://doi.org/10.1080/87565641.2011.540535; PMid:21253990

12. Edwards J, Berube M, Erlandson K, Haug S, Johnstone H, Meagher M, et al. (2011). Developmental coordination disorder in school4aged children born very preterm and/or at very low birth weight: a systematic review. J Dev Behav Pediatr. 32(9): 678–87. https://doi.org/10.1097/DBP.0b013e31822a396a; PMid:21900828

13. Ehrenkranz RA, Walsh MC, Vohr BR. (2005). Validation of the National Institutes of Health consensus definition of bronchopulmonary dysplasia. Pediatrics. 116: 1353–1360. https://doi.org/10.1542/peds.2005-0249; PMid:16322158

14. Farel AM, Hooper SR, Teplin SW, Henry MM, Kraybill EN. (1998). Very-low-birthweight infants at seven years: an assessment of the health and neurodevelopmental risk conveyed by chronic lung disease. J Learn Disabil. 31(2): 118–26. https://doi.org/10.1177/002221949803100202; PMid:9529782

15. Fawke J, Lum S, Kirkby J, Hennessy E, Marlow N, Rowell V, et al. (2010). Lung function and respiratory symptoms at 11 years in children born extremely preterm: the EPICure study. Am J Respir Crit Care Med. 182(2): 237–45. https://doi.org/10.1164/rccm.200912-1806OC; PMid:20378729 PMCid:PMC2913237

16. Gray PH, O'Callaghan MJ, Rogers YM. (2004). Psychoeducational out-come at school age of preterm infants with bronchopulmonary dysplasia. J Paediatr Child Health. 40(3): 114–20. https://doi.org/10.1111/j.1440-1754.2004.00310.x; PMid:15009575

17. Gre`goire MC, Lefebvre F, Glorieux J. (1998). Health and developmental outcomes at 18 months in very preterm infants with bronchopulmonary dysplasia. Pediatrics. 101(5): 856–60. https://doi.org/10.1542/peds.101.5.856; PMid:9565414

18. Greenough A, Alexander J, Boorman J, Chetcuti PA, Cliff I, Lenney W, et al. (2011). Respiratory morbidity, healthcare utilisation and cost of care at school age related to home oxygen status. Eur J Pediatr. 170(8): 969–75. https://doi.org/10.1007/s00431-010-1381-6; PMid:21225284

19. Hack M, Wilson4Costello D, Friedman H, Taylor GH, Schluchter M, Fanaroff AA. (2000). Neurodevelopment and predictors of outcomes of children with birth weights of less than 1000 g: 1992–1995. Arch Pediatr Adolesc Med. 154(7): 725–31. https://doi.org/10.1001/archpedi.154.7.725; PMid:10891026

20. Iyengar A, Davis JM. (2015). Drug therapy for the prevention and treatment of bronchopulmonary dysplasia. Frontiers in Pharmacology.6: 1–7. https://doi.org/10.3389/fphar.2015.00012; PMid:25762933 PMCid:PMC4329808

21. Jobe AH, Bancalari E. (2001). Bronchopulmonary dysplasia. Am J Respir Crit Care Med. 163: 1723–9. https://doi.org/10.1164/ajrccm.163.7.2011060; PMid:11401896

22. Jobe AH. (1999). The new BPD: an arrest of lung development. Pediatr Res. 46(6): 641–3. https://doi.org/10.1203/00006450-199912000-00007; PMid:10590017

23. Jobe AH. (2006). The new BPD. NeoReviews.7: e531-e8. https://doi.org/10.1542/neo.7-10-e531

24. Kotecha SJ, Edwards MO, Watkins WJ, Henderson AJ, Paranjothy S, Dunstan FD, et al. (2013). Effect of preterm birth on later FEV1: a systematic review and meta-analysis. Thorax. 68(8): 760–6. https://doi.org/10.1136/thoraxjnl-2012-203079; PMid:23604458

25. Kuint J, Lerner4Geva L, Chodick G, Boyko V, Shalev V, Reichman B; Israel Neonatal Network. (2017). Rehospitalization through childhood and adolescence: association with neonatal morbidities in infants of very low birth weight. J Pediatr. 188: 135–41.e2.

26. Kurland G, Deterding RR, Hagood JS, Young LR, Brody AS, Castile RG et al. (2013). An official American Thoracic Society clinical practice guideline: classification, evaluation, and management of childhood interstitial lung disease in infancy. Am J Respir Crit Care Med.188(3): 376–94. https://doi.org/10.1164/rccm.201305-0923ST; PMid:23905526 PMCid:PMC3778735

27. Landry JS, Tremblay GM, Li PZ, Wong C, Benedetti A, Taivassalo T. (2016). Lung function and bronchial hyperresponsiveness in adults born prematurely: a cohort study. Ann Am Thorac Soc. 13(1): 17–24. https://doi.org/10.1513/AnnalsATS.201508-553OC; PMid:26523350

28. Lodha A, Sauve` R, Bhandari V, Tang S, Christianson H, Bhandari A et al. (2014). Need for supplemental oxygen at discharge in infants with bronchopulmonary dysplasia is not associated with worse neurodevelopmental outcomes at 3 years corrected age. PLoS One. 9(3): e90843. https://doi.org/10.1371/journal.pone.0090843; PMid:24646665 PMCid:PMC3960119

29. MacLean JE, DeHaan K, Fuhr D, Hariharan S, Kamstra B, Hendson L, et al. (2016). Altered breathing mechanics and ventilatory response during exercise in children born extremely preterm. Thorax. 71(11): 1012–9. https://doi.org/10.1136/thoraxjnl-2015-207736; PMid:27259338 PMCid:PMC5099182

30. Majnemer A, Riley P, Shevell M, Birnbaum R, Greenstone H, Coates AL. (2000). Severe bronchopulmonary dysplasia increases risk for later neurological and motor sequelae in preterm survivors. Dev Med Child Neurol. 42(1): 53–60. https://doi.org/10.1111/j.1469-8749.2000.tb00025.x

31. Martinez FD. (2016). Early4life origins of chronic obstructive pulmonary disease N Engl J Med. 375: 871–8. https://doi.org/10.1056/NEJMra1603287; PMid:27579637

32. Natarajan G, Pappas A, Shankaran S, Kendrick DE, Das A, Higgins RD, et al. (2012). Outcomes of extremely low birth weight infants with bronchopulmonary dysplasia: impact of the physiologic definition. Early Hum Dev.88: 509–515. https://doi.org/10.1016/j.earlhumdev.2011.12.013; PMid:22236557 PMCid:PMC3686277

33. Newman JB, Debastos AG, Batton D, Raz S. (2011). Neonatal respiratory dysfunction and neuropsychological performance at the preschool age: a study of very preterm infants with bronchopulmonary dysplasia. Neuropsychology. 25(5): 666–78. https://doi.org/10.1037/a0023895; PMid:21639640

34. O'Shea TM, Goldstein DJ, deRegnier RA, Sheaffer CI, Roberts DD, Dillard RG. (1996). Outcome at 4 to 5 years of age in children recovered from neonatal chronic lung disease. Dev Med Child Neurol. 38(9): 830–9. https://doi.org/10.1111/j.1469-8749.1996.tb15118.x; PMid:8810715

35. Patel RM, Kandefer S, Walsh MC, Bell EF, Carlo WA, Laptook AR et al. (2015). Causes and timing of death in extremely premature infants from 2000 through 2011. N Engl J Med. 372(4): 331–40. https://doi.org/10.1056/NEJMoa1403489; PMid:25607427 PMCid:PMC4349362

36. Schmidt B, Asztalos EV, Roberts RS, Robertson CM, Sauve RS, Whitfield MF. (2003). Impact of bronchopulmonary dysplasia, brain injury, and severe retinopathy on the outcome of extremely low-birth-weight infants at 18 months: results from the trial of indomethacin prophylaxis in preterms. JAMA. 289(9): 1124–9. https://doi.org/10.1001/jama.289.9.1124; PMid:12622582

37. Schmidt B, Roberts RS, Davis PG, Doyle LW, Asztalos EV, Opie G, et al. (2015). Prediction of late death or disability at age 5 years using a count of 3 neonatal morbidities in very low birth weight infants. J Pediatr. 167(5): 982–6.e2.

38. Short EJ, Kirchner HL, Asaad GR, Fulton SE, Lewis BA, Klein N et al. (2007). Developmental sequelae in preterm infants having a diagnosis of bronchopulmonary dysplasia: analysis using a severity4based classification system. Arch Pediatr Adolesc. Med. 161(11): 1082–7. https://doi.org/10.1001/archpedi.161.11.1082; PMid:17984411

39. Short EJ, Klein NK, Lewis BA, Fulton S, Eisengart S, Kercsmar C et al. (2003). Cognitive and academic consequences of bronchopulmonary dysplasia and very low birth weight: 8-year-old outcomes. Pediatrics. 112(5): e359. https://doi.org/10.1542/peds.112.5.e359; PMid:14595077

40. Singer L, Yamashita T, Lilien L, Collin M, Baley J. (1997). A longitudinal study of developmental outcome of infants with bronchopulmonary dysplasia and very low birth weight. Pediatrics. 100(6): 987–93. https://doi.org/10.1542/peds.100.6.987; PMid:9374570 PMCid:PMC4196670

41. Smith LJ, van Asperen PP, McKay KO, Selvadurai H, Fitzgerald DA. (2008). Reduced exercise capacity in children born very preterm. Pediatrics. 122(2): e287–93. https://doi.org/10.1542/peds.2007-3657; PMid:18676514

42. Smith VC, Zupancic JAF, McCormick MC, Croen LA, Greene J, Escobar GJ, et al. (2004). Rehospitalization in the first year of life among infants with bronchopulmonary dysplasia. J Pediatr. 144(6): 799–803. https://doi.org/10.1016/j.jpeds.2004.03.026; PMid:15192629

43. Stevens TP, Finer NN, Carlo WA, Szilagyi PG, Phelps DL, Walsh MC et al. (2014). Respiratory outcomes of the surfactant positive pressure and oximetry randomized trial (SUPPORT). J Pediatr. 165(2): 240–9.

44. Stoll BJ, Hansen NI, Bell EF, Shankaran S, Laptook AR, Walsh MC, et al. (2010). Neonatal outcomes of extremely preterm infants from the NICHD Neonatal Research Network. Pediatrics. 126: 443–456.

45. Stoll BJ, Hansen NI, Bell EF, Walsh MC, Carlo WA, Shankaran S, et al. (2015). Trends in care practices, morbidity, and mortality of extremely preterm neonates, 1993–2012. JAMA. 314(10): 1039–51. https://doi.org/10.1001/jama.2015.10244; PMid:26348753 PMCid:PMC4787615

46. Trittmann JK, Nelin LD, Klebanoff MA. (2013). Bronchopulmonary dysplasia and neurodevelopmental outcome in extremely preterm neonates. Eur J Pediatr. 172(9): 1173–80. https://doi.org/10.1007/s00431-013-2016-5; PMid:23644648 PMCid:PMC3742432

47. Vohr BR, Coll CG, Lobato D, Yunis KA, O'Dea C, Oh W. (1991). Neurodevelopmental and medical status of low-birthweight survivors of bronchopulmonary dysplasia at 10 to 12 years of age. Dev Med Child Neurol. 33(8): 690–7. https://doi.org/10.1111/j.1469-8749.1991.tb14946.x; PMid:1717327

48. Vohr BR, Wright LL, Dusick AM, Mele L, Verter J, Steichen JJ, et al. (2000). Neurodevelopmental and functional outcomes of extremely low birth weight infants in the National Institute of Child Health and Human Development Neonatal Research Network, 1993–1994. Pediatrics. 105(6): 1216–26. https://doi.org/10.1542/peds.105.6.1216; PMid:10835060

49. Walsh MC, Morris BH, Wrage LA, Vohr BR, Poole WK, Tyson JE et al. (2005). Extremely low birthweight neonates with protracted ventilation: mortality and 184month neurodevelopmental outcomes. J Pediatr. 146(6): 798–804. https://doi.org/10.1016/j.jpeds.2005.01.047; PMid:15973322

50. Walsh MC, Wilson-Costello D, Zadell A, Newman N, Fanaroff A. (2003). Safety, reliability, and validity of a physiologic definition of bronchopulmonary dysplasia. J Perinatol. 23: 451–6. https://doi.org/10.1038/sj.jp.7210963; PMid:13679930

51. Walter EC, Koepsell TD, Chien JW. (2011). Low birth weight and respiratory hospitalizations in adolescence. Pediatr Pulmonol. 46(5): 473–82. https://doi.org/10.1002/ppul.21398; PMid:21194168

52. Welsh L, Kirkby J, Lum S, Odendaal D, Marlow N, Derrick G et al. (2010). The EPICure study: maximal exercise and physical activity in school children born extremely preterm. Thorax. 65(2): 165–72. https://doi.org/10.1136/thx.2008.107474; PMid:19996340