- Linear IgA-bullous dermatosis in a child during martial law. Clinical case
Linear IgA-bullous dermatosis in a child during martial law. Clinical case
Modern Pediatrics. Ukraine. (2022). 8(128): 85-89. doi 10.15574/SP.2022.128.85
Nedelska S. M.1,3, Svyatenko T. V.2, Kuznetsova O. D.1, Pukhyr V. P.1
1Zaporizhzhia State Medical University, Ukraine
2Dnipro State Medical University, Ukraine
3MNPE «City Children’s Hospital No. 5» of Zaporizhzhia City Council, Ukraine
For citation: Nedelska SM, Svyatenko TV, Kuznetsova OD, Pukhyr VP. (2022). Linear IgA-bullous dermatosis in a child during martial law. Clinical case. Modern Pediatrics. Ukraine. 8(128): 85-89. doi 10.15574/SP.2022.128.85.
Article received: Sep 03, 2022. Accepted for publication: Dec 19, 2022.
Linear IgA-bullous dermatosis (chronic childhood disease) – a rare autoimmune subepithelial vesiculobulular disease caused by the formation of IgA autoantibodies, directed against various hemidesmosomal antigens, which is more common in children of early preschool age.
Purpose – is to describe our own clinical observation of a case of linear IgA-bullous dermatosis in a girl aged 2 years 9 months to increase the level of alertness of doctors regarding this pathology in children, especially at an early age.
Clinical case. At the time of admission her condition was of moderate severity due to the presence of a confluent papular-vesicular rash located on the face, neck, limbs. The rash was accompanied by the development of erosions surrounded by a ring of vesicles and caused a feeling of discomfort, severe itching. During local treatment and systemic antifungal tablets, the child’s condition improved, however, complete remission was not achieved after 7 week of the therapy, new bullas appeared. Additional diagnostic investigation allowed to suppose the diagnosis linear IgA – bullous dermatosis. Adjustment of therapy was made (steroids per os administration) and the child's condition improved gradually in a month.
The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
Keywords: linear IgA-bullous dermatosis; bullous diseases, IgA, autoimmune diseases, systemic glucocorticosteroids, children.
REFERENCES
1. Becker M, Schumacher N, Schmidt E, Zillikens D, Sadik CD. (2021). Evaluation and Comparison of Clinical and iLaboratory Characteristics of Patients With IgA Epidermolysis Bullosa Acquisita, Linear IgA Bullous Dermatosis, and IgG Epidermolysis Bullosa Acquisita. JAMA dermatology. 157 (8): 917-923. https://doi.org/10.1001/jamadermatol.2021.0762; PMid:34160564 PMCid:PMC8223139
2. Bernett CN, Fong M, Yadlapati S, Rosario-Collazo JA. (2022). Linear IGA Dermatosis. In StatPearls. StatPearls Publishing.
3. Corrà A, Bonciolini V, Quintarelli L, Verdelli A, Caproni M. (2022). Linear IGA bullous dermatosis potentially triggered by vaccination. International journal of immunopathology and pharmacology. 36: 20587384211021218. https://doi.org/10.1177/20587384211021218; PMid:35001680 PMCid:PMC8753231
4. Cozzani E, Di Zenzo G, Gasparini G, Salemme A, Agnoletti AF, Vassallo C et al. (2020). Autoantibody Profile of a Cohort of 54 Italian Patients with Linear IgA Bullous Dermatosis: LAD-1 Denoted as a Major Auto-antigen of the Lamina Lucida Subtype. Acta dermato-venereologica. 100 (4): adv00070. https://doi.org/10.2340/00015555-3415; PMid:32011724 PMCid:PMC9128871
5. Garel B, Ingen-Housz-Oro S, Afriat D, Prost-Squarcioni C, Tétart F, Bensaid B et al. (2019). Drug-induced linear immunoglobulin A bullous dermatosis: A French retrospective pharmacovigilance study of 69 cases. British journal of clinical pharmacology. 85 (3): 570-579. https://doi.org/10.1111/bcp.13827; PMid:30511379 PMCid:PMC6379232
6. Genovese G, Venegoni L, Fanoni D, Muratori S, Berti E, Marzano AV. (2019). Linear IgA bullous dermatosis in adults and children: a clinical and immunopathological study of 38 patients. Orphanet journal of rare diseases. 14 (1): 115. https://doi.org/10.1186/s13023-019-1089-2; PMid:31126328 PMCid:PMC6534856
7. Lammer J, Hein R, Roenneberg S, Biedermann T, Volz T. (2019). Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature. Acta dermato-venereologica. 99 (6): 508-515. https://doi.org/10.2340/00015555-3154; PMid:30809685
8. Malik AM, Tupchong S, Huang S, Are A, Hsu S, Motaparthi K. (2021). An Updated Review of Pemphigus Diseases. Medicina (Kaunas, Lithuania). 57 (10): 1080. https://doi.org/10.3390/medicina57101080; PMid:34684117 PMCid:PMC8540565
9. Saleem M, Iftikhar H. (2019). Linear IgA Disease: A Rare Complication of Vancomycin. Cureus. 11 (6): e4848. https://doi.org/10.7759/cureus.4848
10. Valle Del Barrio B, Luraschi D, Micheletti R, Hiffler L, Arias AP. (2019). Bullous dermatosis suspected in an 8-month-old child in Guinea-Bissau. Oxford medical case reports. 4: omz004. https://doi.org/10.1093/omcr/omz004; PMid:31001428 PMCid:PMC6464016
Modern Pediatrics. Ukraine. (2022). 8(128): 85-89. doi 10.15574/SP.2022.128.85
Linear IgA-bullous dermatosis in a child during martial law. Clinical case
Nedelska S. M.1,3, Svyatenko T. V.2, Kuznetsova O. D.1, Pukhyr V. P.1
1Zaporizhzhia State Medical University, Ukraine
2Dnipro State Medical University, Ukraine
3MNPE «City Children’s Hospital No. 5» of Zaporizhzhia City Council, Ukraine
Недельська Світлана Миколаївна – https://orcid.org/0000-0003-2277-3875
Святенко Тетяна Вікторівна – https://orcid.org/0000-0003-4303-2937
Пухир Валерія Павлівна – https://orcid.org/0000-0002-5458-5142
For citation: Nedelska SM, Svyatenko TV, Kuznetsova OD, Pukhyr VP. (2022). Linear IgA-bullous dermatosis in a child during martial law. Clinical case. Modern Pediatrics. Ukraine. 8(128): 85-89. doi 10.15574/SP.2022.128.85.
Article received: Sep 03, 2022. Accepted for publication: Dec 19, 2022.
Linear IgA-bullous dermatosis (chronic childhood disease) – a rare autoimmune subepithelial vesiculobulular disease caused by the formation of IgA autoantibodies, directed against various hemidesmosomal antigens, which is more common in children of early preschool age.
Purpose – is to describe our own clinical observation of a case of linear IgA-bullous dermatosis in a girl aged 2 years 9 months to increase the level of alertness of doctors regarding this pathology in children, especially at an early age.
Clinical case. At the time of admission her condition was of moderate severity due to the presence of a confluent papular-vesicular rash located on the face, neck, limbs. The rash was accompanied by the development of erosions surrounded by a ring of vesicles and caused a feeling of discomfort, severe itching. During local treatment and systemic antifungal tablets, the child’s condition improved, however, complete remission was not achieved after 7 week of the therapy, new bullas appeared. Additional diagnostic investigation allowed to suppose the diagnosis linear IgA – bullous dermatosis. Adjustment of therapy was made (steroids per os administration) and the child's condition improved gradually in a month.
The research was carried out in accordance with the principles of the Helsinki Declaration. The informed consent of the patient was obtained for conducting the studies.
No conflict of interests was declared by the authors.
Keywords: linear IgA-bullous dermatosis; bullous diseases, IgA, autoimmune diseases, systemic glucocorticosteroids, children.
REFERENCES
1. Becker M, Schumacher N, Schmidt E, Zillikens D, Sadik CD. (2021). Evaluation and Comparison of Clinical and iLaboratory Characteristics of Patients With IgA Epidermolysis Bullosa Acquisita, Linear IgA Bullous Dermatosis, and IgG Epidermolysis Bullosa Acquisita. JAMA dermatology. 157 (8): 917-923. https://doi.org/10.1001/jamadermatol.2021.0762; PMid:34160564 PMCid:PMC8223139
2. Bernett CN, Fong M, Yadlapati S, Rosario-Collazo JA. (2022). Linear IGA Dermatosis. In StatPearls. StatPearls Publishing.
3. Corrà A, Bonciolini V, Quintarelli L, Verdelli A, Caproni M. (2022). Linear IGA bullous dermatosis potentially triggered by vaccination. International journal of immunopathology and pharmacology. 36: 20587384211021218. https://doi.org/10.1177/20587384211021218; PMid:35001680 PMCid:PMC8753231
4. Cozzani E, Di Zenzo G, Gasparini G, Salemme A, Agnoletti AF, Vassallo C et al. (2020). Autoantibody Profile of a Cohort of 54 Italian Patients with Linear IgA Bullous Dermatosis: LAD-1 Denoted as a Major Auto-antigen of the Lamina Lucida Subtype. Acta dermato-venereologica. 100 (4): adv00070. https://doi.org/10.2340/00015555-3415; PMid:32011724 PMCid:PMC9128871
5. Garel B, Ingen-Housz-Oro S, Afriat D, Prost-Squarcioni C, Tétart F, Bensaid B et al. (2019). Drug-induced linear immunoglobulin A bullous dermatosis: A French retrospective pharmacovigilance study of 69 cases. British journal of clinical pharmacology. 85 (3): 570-579. https://doi.org/10.1111/bcp.13827; PMid:30511379 PMCid:PMC6379232
6. Genovese G, Venegoni L, Fanoni D, Muratori S, Berti E, Marzano AV. (2019). Linear IgA bullous dermatosis in adults and children: a clinical and immunopathological study of 38 patients. Orphanet journal of rare diseases. 14 (1): 115. https://doi.org/10.1186/s13023-019-1089-2; PMid:31126328 PMCid:PMC6534856
7. Lammer J, Hein R, Roenneberg S, Biedermann T, Volz T. (2019). Drug-induced Linear IgA Bullous Dermatosis: A Case Report and Review of the Literature. Acta dermato-venereologica. 99 (6): 508-515. https://doi.org/10.2340/00015555-3154; PMid:30809685
8. Malik AM, Tupchong S, Huang S, Are A, Hsu S, Motaparthi K. (2021). An Updated Review of Pemphigus Diseases. Medicina (Kaunas, Lithuania). 57 (10): 1080. https://doi.org/10.3390/medicina57101080; PMid:34684117 PMCid:PMC8540565
9. Saleem M, Iftikhar H. (2019). Linear IgA Disease: A Rare Complication of Vancomycin. Cureus. 11 (6): e4848. https://doi.org/10.7759/cureus.4848
10. Valle Del Barrio B, Luraschi D, Micheletti R, Hiffler L, Arias AP. (2019). Bullous dermatosis suspected in an 8-month-old child in Guinea-Bissau. Oxford medical case reports. 4: omz004. https://doi.org/10.1093/omcr/omz004; PMid:31001428 PMCid:PMC6464016