HEALTH OF WOMAN. 2019.2(138): 46–48; doi 10.15574/HW.2019.138.46

Rymarchuk M. І. , Cheredarchuk A. R. , Gibson Okoloch  Onieca
SHEI «Ivano-Frankivsk National Medical University»

To determine the correlation of local non-progressive abruption of placenta and the development of placental dysfunction with undifferentiated connective tissue dysplasia (UCTD), we have conducted the case-consequence research with 100 patients. The research included two stages. At the first stage, all the predictors of this complication were divided into 4 groups: somatic anamnesis, obstetric, gynecological and infectious anamnesis, course of the given pregnancy and results of tests for Phase-II detoxification gene polymorphism. At the second stage, all the significant predictors were included in a multifaceted logistic regressive analysis.

The most significant causes of local non-progressive abruption of placenta at placental dysfunction are the following: UCTD (OR-18.86; 6.58–54.02), its visceral markers such as scoliosis (OR 5.76; 2.08–15.97), heart diseases (mitral valve prolapse, hypertensive neurocirculatory dystonia, supplemental chord) (OR 8.61; 3.11–23.83), myopia (OR 6.25; 2.26–17.29), platypodia (OR 4.49; 1.61–12.55), renal diseases (OR 7.94; 2.87–21.98).

The sheer presence of UCTD in this category of patients increases by 18 times the risk of disorder of trophoblast invasion and development of placental dysfunction.

Key words: local placental abruption, undifferentiated connective tissue dysplasia, placental dysfunction, gene polymorphism.

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