PERINATOLOGIYA I PEDIATRIYA.2015.2(62):43-46;doi10.15574/PP.2015.62.43

Instumentalni markers of endothelial dysfunction in Schonlein—Henoch purpura in children

Dudnyk V. M., Korol T. G.

Vinnytsia National Medical University, Vinnytsia, Ukraine

Purpose — to determine the instrumental markers of endothelial dysfunction in Schonlein—Genoch purpura in children.

Patients and methods. 123 children with Schonlein—Henoch purpura aged 1 to 18 years (mean age 6.44±0.18 years) were under the supervision. Given the current feature SHP and clinical manifestations organized distribution of patients depending on the form (skin, skin-articular, mixed and blended with renal disease) and disease activity. To determine the presence of endothelial dysfunction, an assessment of structural changes and functional state of the vascular endothelium of the carotid artery and brachial using Doppler ultrasound scanner in «Philips HDII XE» in B-mode sensor linear format in the frequency range from 5 to 15 MHz at rest .

Results and conclusions. Found that in children with SHP was significantly more common skin and skin — articular form of the disease — 49 (39.8%) and 57 (46.3%) children, respectively, with a predominance of II degree of activity. As a result of Doppler ultrasound of the carotid artery and brachial we found that patients who had maximum activity of the disease, and found structural changes of the functional state of the endothelium — the IM thickness CA and BA 1.3–1.5 times more than in healthy children. Reported violations hemodynamic characteristics of blood flow in the brachial artery (deceleration) patients had grade III disease activity — Vps (34.59±3.18 mm/s), Ved (2.72±0.57 mm/s), S/D (10.15±0.82), indicating a dependence on the activity of endothelial dysfunction Schonlein—Henoch purpura.

Key words: Schonlein—Henoch purpura, children, endothelial dysfunction, Doppler ultrasound.