HEALTH OF WOMAN.2015.2(98):165–167; doi 10.15574/HW.2015.98.165 
 

Influence of womens hepato-biliary system for resulting of assisted reproductive technologies 
 

Boichuk A. G.

National Medical Academy of Postgraduate Education P. L. Shupyk, Kiev 
 

Conducted a retrospective analysis of 614 outpatients women seeking treatment for infertility who have been assigned and were treated with the use of assisted reproductive technologies, confirmed the role of functional disorders of the metabolic system «hypothalamic–pituitary–ovarian–liver» in causing infertility. In women with infertility found high rates of pathology hepato-biliary system and obesity. The frequency of these diseases was significantly higher in women with unsuccessful attempts to ART. It is also shown a significant role of the hepato-biliary system in the efficiency ART, pregnancy progress and consequences. The authors noted the need for additional complex studies to establish the specific pathogenetic mechanisms and therapeutic methods influence. 
 

Key words: infertility, assisted reproductive technologies, pregnancy, hepato-biliary system. 
 

REFERENCES

1. Кантемирова З.Р., Торчинов А.М., Жигулина Т.А. и др. 2003. Стероидные гормоны, миома матки и нарушения функции печени: патогенез и перспективы лечения. Лечащий Врач 10:18–20.

2. Дубоссарская Ю.А. 2010. Патология гепатобилиарной системы в практике гинеколога. Медицинские аспекты здоровья женщины 3(30):12–19.

3. Вихляева Е.М. 2006. Руководство по эндокринной гинекологии. 3-е изд., доп. М. Медицинское информационное агентство: 784.

4. Петухов В.А., Торчинов А.М., Алексеева Е.А. и др. 2004. Морфофункциональные нарушения органов гепатобилиарной системы при миоме матки: возможные терапевтические подходы. Фарматека 2:80–86.

5. Назаренко Т.А., Корнеева И.Е., Соколова М.Ю., Аксененко А.А. 2009. Нарушение функции печени у пациентки с синдромом гиперстимуляции яичников. Проблемы репродукции 3:70–73.

6. Della T.S., Rando G., Meda C. et al. 2011. Amino Acid-Dependent Activation of Liver Estrogen Receptor Alpha Integrates Metabolic and Reproductive Functions via IGF-1. Cell Metabolism 13(2):205–214. http://dx.doi.org/10.1016/j.cmet.2011.01.002; PMid:21284987

7. Maschi M., Matrorani A. 1974. Steroids sessuali с fimzione hepatica. Minerva ginec. 26; 9:526–532.