PERINATOLOGIYA I PEDIATRIYA.2015.3(63):71-74; doi 10.15574/PP.2015.63.71 
 

Influence of vitamin d on the immune system: double jeopardy of development of osteogenesis disorders in children with recurrent bronchitis 
 

Vertegel A. A., Ovcharenko L. S.

SI «Zaporizhzhya Medical Academy of Postgraduate Education of Ministry of Health of Ukraine», Zaporizhzhya, Ukraine 
 

Purpose — to establish of vitamin D sufficiency in children with recurrent bronchitis, and study the impact of 25(OH)D serum level on the immune system functioning. 
 

Patients and methods. The study involved 120 children aged 4 to 10 years (mean age — 7 years 7 months), who were divided into two groups (60 children each): 1) children with recurrent bronchitis; 2) children, occasionally ill with upper respiratory tract infections. 
 

Results. In 60 children with RB (100%) have a decrease 25(OH)D serum level less than 30 ng/mL (group 2 — in 25 (41.7%) children), (P<0.05). Indicators of the immune system in children with recurrent bronchitisshowed an increase of neutrophils phagocytic activity (P<0.05), the NST-test index (P<0.05), increase of CD16 (P<0.05), CD25 (P<0.05) in the blood, serum IgG (P<0.05) and IgM (P<0.05) due to lower of serum IgA (P<0.05) and saliva sIgA (P<0.05), the increase of serum IL-6 (P<0.05), TNF-a (P<0.05), IFN-g (P<0.05) and a decrease of IL-10 (P<0.05), that could negatively affect the condition of bone tissue in the form of strengthening bone resorption. 
 

Conclusions. The decrease of 25(OH)D serum level in 100% of children with recurrent bronchitis describes the presence of vitamin D insufficient. This complex metabolic state has a direct (through the calcium-phosphorus metabolism) and indirect (via activation of immune mechanisms of bone resorption) negative impact on bone formation processes. 
 

Key words: children, vitamin D, immunity, bronchitis. 
 

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