HEALTH OF WOMAN. 2020.5-6(151-152): 38-42; doi 10.15574/HW.2020.151-152.38
Malachynska M.^1,2, Veresniuk N.^1,2
1СNP of the Lviv Regional Council “Lviv Regional Center for Reproductive Health”
²Danylo Halytskyi Lviv National Medical University

The interplay between the microbiome and the reproductive organ system is a complex functioning mechanism that continues to be the subject of much contemporary research. The microbiome of the reproductive sphere plays an important role in the onset and delivery of pregnancy, the frequency of live births, influences the result of assisted reproductive technologies and the like. This study substantiates the feasibility of using a multi-strain probiotic in the complex treatment of infertile patients.
The objective: to investigate the efficacy of administering a multi-strain probiotic to patients with infertility.
Materials and methods. Under our observation, from 2017 to 2020, there were 94 patients with infertility. The age of women ranged from 22 to 35 years. All participants in the main group, 64 patients, received a multi-strain probiotic, which included 5 strains of bacteria, 1 capsule once a day during meals, for 1 month before planning the pregnancy. The comparison group consisted of 30 women with infertility who did not take any probiotics.
Results. Analyzing the results of vaginal biocenosis examination in the examined women, normocenosis was established in 33 (35.1%) patients. Bacterial vaginosis occurred in almost every fourth patient (23.4%), every third woman (30.9%) had an intermediate type of smear, and 10.6% of patients were diagnosed with nonspecific colpitis. Among the patients in the main group, pregnancy occurred in 21 women, accounting for 32.8%. At the same time, 4 patients (13.3%) became pregnant in the comparison group, one of whom was after intrauterine insemination and another was due to IVF (p<0.5). No women of the main group were observed side effects of the drug.
Conclusion. The incidence of pregnancy in infertile patients who used a multisystem probiotic at the pre-gravid stage was 32.8%. The use of a multi-strain probiotic increases the incidence of implantation in infertile patients (p = 0.0464), however, more research is needed on this topic.
Keywords: microbiome, lactobacillus, infertility, pregnancy.

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