PERINATOLOGIYA I PEDIATRIYA. 2017.1(69):115-120; doi 10.15574/PP.2017.69.115

Incidence peculiarities of acute respiratory disease among children with undifferentiated connective tissue dysplasia

Oshlyanska O. A., Vovk V. M.
SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv
LLC «Children's Medical Center «Dobrobyt», Kyiv, Ukraine

Purpose — to study the peculiarities of acute respiratory pathology among children with undifferentiated connective tissue dysplasia.

Materials and methods. We conducted retrospective analysis of data history and the overall incidence of children with acute respiratory disease according to 117 patient cards of children aged 1 to 10 years, who were observed in LLC «Children's Medical Center «Dobrobyt». There were 55 children with no signs of undifferentiated connective tissue dysplasia and 62 children with clinical manifestations of undifferentiated connective tissue dysplasia.

Results. It has been shown that children with clinical manifestations of undifferentiated connective tissue dysplasia twice more often suffered from respiratory diseases and were proned to long-term course, more often have complications in the form of otitis, bronchitis, and adenoiditis. The results of the analysis showed a significant difference of the reported acute respiratory diseases with complications and long course before vaccination and after vaccination against pneumococcus among children with clinical manifestations of undifferentiated connective tissue dysplasia. The preventive doses of vitamin D intake had no effect on the incidence rate of children with undifferentiated connective tissue dysplasia.

Conclusions. Our research showed that children with clinical manifestations of undifferentiated connective tissue dysplasia much more often suffer from acute respiratory infections, including the high_risk group that consists of children with complicated perinatal history. Preventative vaccination with pneumococcal vaccines is efficacious in reducing the incidence rate of acute respiratory disease among children with undifferentiated connective tissue dysplasia.

Key words: children, undifferentiated connective tissue dysplasia, acute respiratory disease.

References

1. Abbakumova LN. 2006. Clinical forms of connective tissue dysplasia among children. S-Petersburg: 36. http:window.edu.ru.window_catalog/files/r60403/displ.pdf

2. Vereschagina GN. 2008. Systemic connective tissue dysplasia. Clinical syndromes, diagnosis, treatment approaches: a manual for physicians. Novosibirsk state medical institute. Novosibirsk: 70.

3. Vershynina MV. 2004. Features of community-acquired pneumonia among patients with signs of connective tissue dysplasia. Dis … Candidate of Medical Science. Omsk: 160. http:www.dissercat.com.content.kardio-respiratornaya-sistema-pri-nebolnichnoi-pnevmonii-u-molodykh-patsientov-s-sindromom.

4. Ilina IYu, Dobrokhotova YuE, Zhdanova MS, Yumyna SV. 2009. Possible violations of the immune status of women with connective tissue dysplasia. Immunology. 1: 57-59.

5. Nechaeva GI, Viktorova IA, Druk IV, Vershynina MV. 2004. Connective tissue dysplasia: Pulmonary aspects. Pulmonology. 2: 116-119.

6. Ilina IYu, Dobrohotova YuE, Zhdanova MS. 2009. Dysplasia of connective tissue and possible changes in the immune status among women with genital prolapse. Newsletter of Russian University of People’s Friendship, series "Medicine". 5: 72-76.

7. Kadurina TI. 2000. Hereditary collagenopathy (clinic, diagnostics, treatment and medical examination). S-Petersburg, Nevsky Dialect: 271.

8. Klementov AV. 2005. The clinical significance of undifferentiated connective tissue dysplasia. Thesis abstract… Doctor of Medical Sciences. М: 27.

9. Kondusova YuV. 2009. Asthma, associated with connective tissue dysplasia: features of the course and rehabilitation. Thesis abstract. … Dis. … Candidate of Medical Science. Voronezh. http://www.pandia.ru/393426/

10. Marushko YuV, Marushko TV, Hordyenko IN. 2009. The clinical significance of connective tissue dysplasia syndrome for medical and sports practice. Sports medicine. 2: 24-31.

11. Pochynok TV, Vasyukova MM, Gorobets NІ et al. 2007. Undifferentiated connective tissue dysplasia among children: diagnostics and treatment strategy. Medicine of Transport of Ukraine. 1: 85- 92.

12. Nelina IN. 2004. Status of immunological homeostasis among children and adolescents with a poor course of connective tissue dysplasia. Materials of research and practical conference Pathology of the connective tissue – Basis of chronic diseases among children and adolescents. Kharkiv: 99-100.

13. Nesterenko ZV. 2010. Transformation of structure of human organs and tissues. Health of the child. 4(25). http:pediatric.mif-ua.com/archive/issue-13219/article-13266/.

14. Oshlyanska OA. 2012. Background and immunopathological mechanisms of development of rheumatic diseases among children with connective tissue dysplasia. Thesis abstract … Doctor of Medical Sciences. Kyiv: 31.

15. Rudoi AS. 2010. Diseases of the upper departments of gastrointestinal tract among young people associated with hereditary disorders of connective tissue (features of the clinical picture, etiology, pathomorphogenesis and prognosis of clinical course). Thesis abstract … Doctor of Medical Sciences.S-Petersburg: 44. http://oldvak.ed.gov.ru/common/img/uploaded/files/vak/2010/announcements/medicin/22-03/RudoyAS.doc

16. Torshyn IYu, Gromova OA. 2008. Molecular mechanisms of magnesium and of connective tissue dysplasia. Russian medical journal. 2: 263-269.

17. Tsymbalіsta OL, Gavrylyuk OІ. 2011. Syndrome of undifferentiated connective tissue dysplasia among children, sick with complicated community-acquired pneumonia. Child’s Health. 3(10): 52-54.

18. Tsao BP, Cantor RM, Grossman JM et al. 1998. ADPRT alleles from the chromosome 1q41-q42 linked region are associated with SLE. Arthritis Rheum. 41: 80.