HEALTH OF WOMAN. 2017.8(124):65–70; doi 10.15574/HW.2017.124.65  

Shcherbina N. A., Vygovskaya L. A.
Kharkov National Medical University (Kharkov)

The objective: to study the effect of immunocorrecting therapy on the state of blood lipid spectrum in pregnant with intrauterine infection.
Patients and methods. The study involved examination of three groups of pregnant with viral, bacterial and mixed infection. Each of the groups was divided into 2 subgroups: with subsequent implementation of infection in newborns and without it. Control group included patients with physiological pregnancy. The pregnant received immunocorrecting therapy. Blood serum was assessed to determine the levels of total cholesterol (TC), triglycerides (TG), high, low and very low density lipoproteins (HDL, LDL, VLDL).
Results. The study implied the assessment of the effect of the elaborated immunocorrecting complex on the state of blood lipid spectrum in pregnant with intrauterine infection. In the group of patients with viral infections, regardless of its subsequent implementation, the use of the developed therapeutic complex triggered activation of cholesterol metabolism and reduction of hypertriglyceridemia to normal TG content in blood. In patients with bacterial infection, regardless of its implementation, the performed treatment resulted in cholesterol metabolism normalization. In the subgroup with mixed infection in its implementation, the treatment neutralized triglyceridemia and normalized TG level. In the subgroup with mixed infection without its implementation, the treatment allowed to normalize the level of TG and VLDL and increase HDL.
Conclusions. The use of the elaborated immunocorrecting therapy has a positive effect on the metabolism of lipids, which reflects the lipid profile of blood. The main effect of the treatment is the normalization of the levels of triglycerides in pregnant and their carriers VLDL, and this effect is manifested with all the variants of infection under investigation. The detected increase in the level of HDL is indicative of an increase in the reverse transport of cholesterol and activation of its metabolism. This allows us to consider that the use of this therapeutic complex stimulates compensatory metabolic processes in the body of pregnant women, despite the presence of infection.
Key words: intrauterine infection, lipid spectrum, immunocorrecting therapy.

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