HEALTH OF WOMAN. 2016.1(107):63–66; doi 10.15574/HW.2016.107.63 
 

Immunohistological chemichal research of the apoptosis and endometrium APUD-system state interreaction in normal and pathological conditions 
 

Benyuk V. O., Kalenskaya O. V., Goncharenko V. M., Strokan A. M., Bubnov R. V.

Clinical Hospital ‘Pheophania’ of State Affairs Department, Kyiv, Ukraine

Bogomolets National Medical University, Obstetrics and Gynaecology department №3, Kyiv 
 

We studied the levels of pro- and anti-apoptotic factors (p53, Bcl-2), the content of the EC cells of APUD system in 228 women of reproductive age with endometrial hyperplasia and endometrial cancer. The development of endometrial hyperplasia without atypia was characterized by low activation of local APUD system, and lack of anti-apoptotic protein p53 and increased levels of Bcl-2 in the epithelium of glands and stroma in the endometrium.

In atypical forms of endometrial hyperplasia we observed the 1,5-fold increased expression of Bcl-2 (p<0,05) and the emergence of pro-apoptotic protein p53, and also determined the 5,5-fold increasing the number of APUD cells compared to the physiological level.

In cases of malignant transformation and development of endometrial adenocarcinoma, we noted the 9,8-fold increase of expression of EC cells and 1,3-fold increase of the Bcl-2 level, determined by the high content of protein p53, which indicates a high level of activation APUD system and imbalance between processes of apoptosis and proliferation. 
 

Key words: endometrial hyperplasia, endometrial cancer, APUD system, EC cells, p53, bcl-2, apoptosis, proliferation. 
 

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