HEALTH OF WOMAN. 2016.5(111):43–47; doi 10.15574/HW.2016.111.43 
 

Imbalance in the system L-arginin-NO in pathogenesis of obstetric complications and intrauterine growth retardation (Literature review) 
 

Basystyi O. V.

SI «Institute of Pediatrics, Obstetrics and Gynecology, NAMS of Ukraine», Kiev

The data of domestic and foreign literature on etiology, pathogenesis and intrauterine growth retardation diagnosis are presented in the paper. It highlights pathogenetic role of nitric oxide deficiency in case of obstetric complications and intrauterine growth retardation.

Key words: intrauterine growth retardation (IUGR), system L-arginin–NO, obstetric complications.

REFERENCES

1. Ashurova NG, Ismatova MI. 2015. The modern view on the problem of intrauterine growth retardation (review article). Science. Thought 3:13-18.

2. Ashurova NG, Ismatova MI. 2015. On intrauterine growth retardation. The health is the basis of human development: Problems and Solutions 1:61–63.

3. Bikmetova EU, Trishkin AG, Artymuk NV. 2012. Intrauterine growth retardation. The frequency, risk factors. A Mother and a child in Kuzbass 1:27–31.

4. Volodin NN, Chernyshov VN, Degtyarev NN. 2005. Neonatology. Handbook. M, Academy:448.

5. Gureev VA, Pokrovsky MV, Polyanskaya OS et al. 2011. Ways of correction of NO-deficient condition in case of the pathology of pregnant women in the experiment. Scientific bulletin of Belgorod State University. Series: Medicine. Pharmacy 13(4):40–43.

6. Zhirova NV. 2004. The peculiarities of pregnancy course in women, depending on the functional condition of the vascular endothelium and its role in the formation of chronic placental insufficiency. Clinical experimental investigation, author's abstract of the dissertation for a Candidate’s degree in Medical Sciences: 14.00.01, 14.00.16. Altai State Medical Institute, Barnaul:24.

7. Zverko VL, Maksimovich NE, Milosh TC. 2010. Lack of nitric oxide as one of the pathogenetic factors for threat of miscarriage. Grodno State Medical University Journal 3:60–62.

8. Ignatkevich AI, Petrenko YV, Ivanov DO et al. 2014. Features of postnatal growth in children born with intrauterine growth retardation. Annals of modern clinical medicine 6:26–32.

9. Ivanov IE, Rodionov VA, Zolnikova TV. 2011. Hypotrophy and intrauterine growth restriction in children. Practical guidance for Physicians. Chuvash Autonomous Institution «Postgraduate Doctors’ Training Institute», Cheboksary:115.

10. Ignatko IV, Kardanova MA, Tolkach UI, Fedyunina IA. 2015. Decompensated placental insufficiency and critical condition of the fetus. Issues on Gynecology, Obstetrics and Perinatology 5:36–46.

11. Kovalyov EV, Lazuko SS, Zan’ko UV. 2015. Diagnostic value of determination of inducible NO-synthase in the diagnosis of fetal growth retardation in the third trimester of pregnancy. Motherhood and childhood protection 1:36–40.

12. Kocherova VV, Shcherbak VA. 2015. Intrauterine growth retardation: risk factors, diagnosis, long-term effects (Review article). Russian Journal of Pediatrics 2:36–42.

13. Kazantseva EV, Dolgushina NV. 2012. Modern aspects of pathogenesis, diagnosis and management of pregnant women with fetal growth retardation. Transbaikalia Medical Gazette 2:170–177.

14. Kirillova EA. 2015. The physical and psychomotor development of children with intrauterine growth restriction. Obstetrics and Gynecology 11:23–27.

15. Linde VA, Pogorelova TN, Drukker NA et al. 2011. The role of arginine imbalance in the development of placental insufficiency. Obstetrics and Gynecology 4:26–30.

16. Makarov SP, Yudina EV, Borovkova EI. 2014. Fetal growth retardation: medical tactics: training manual.2^nd edition. М, MEDpress-inform:54.

17. Markin LB. 2003. Fetal growth retardation (diagnosis, prophylaxis, treatment). Treatment and diagnosis 2:41–44.

18. Prysyazhnyuk VP. 2009. Condition of maternal-fetal circulation and correction of disorders in case of fetal growth restriction, author's abstract of the dissertation for a Candidate’s degree in Medical Sciences: 14.01.01. Institute of Pediatrics, Obstetrics and Gynecology of AMS of Ukraine, Kyiv:20.

19. Radzynskyy VE, Milovanov AP. 2004. Extraembryonal and amniotic structure in normal and complicated pregnancy. М, Medical Information Agency (МIА):393.

20. Sliusar TI, Pylypenko ON, Dzhelomanova OA, Levchenko II. 2015. Changes of fetoplacental complex indices in patients with intrauterine growth retardation and antenatal loss in case history. Woman’s Health 3:156–158.

21. Strizhakov AN, Ignatko IV, Timokhina EV, Belotserkovtseva LD. 2014. Fetal growth retardation syndrome: pathogenesis, diagnosis, treatment, obstetric tactics. М, GEOTAR-Media:115.

22. Baschat AA. 2010. Fetal growth restriction – from observation to intervention. J. Perinat. Med. 38;3:239–246. http://dx.doi.org/10.1515/jpm.2010.041

23. Bamfo JE, Odibo AO. 2011. Diagnosis and management of fetal growth restriction. J. Pregnancy. 2011. Art. 640715. http://dx.doi.org/10.1155/2011/640715; PMid:21547092 PMCid:PMC3087156

24. Baschat AA. 2014. Neurodevelopment after fetal growth restriction. Fetal Diagn Ther. 36;2:136–142. http://dx.doi.org/10.1159/000353631; PMid:23886893

25. Crocker IP, Sipos PI. 2013. Review:Endothelial progenitor cells in pregnancy and obstetric pathologies. Placenta 34:S62-S67. http://dx.doi.org/10.1016/j.placenta.2013.01.003; PMid:23395298

26. Giannubilo SR, Menegazzi M, Tedeschi E et al. 2008. Doppler analysis and placental nitric oxide synthase expression during fetal growth restriction. J. Matern. Fetal. Neonatal. Med. 21;9:617–622. http://dx.doi.org/10.1080/14767050802214774; PMid:18828052

27. Goodrum LA, Saade GR, Belfort MA et al. 2003. Arginine flux and nitric oxide production during human pregnancy and postpartum. J. Soc. Gynecol. Investig. 10;7:205-400. http://dx.doi.org/10.1016/s1071-5576(03)00137-0; http://dx.doi.org/10.1016/s1071-55760300137-0

28. Gratacуs E, Figueras F. 2014. Fetal growth restriction as a perinatal and long-term health problem: clinical challenges and opportunities for future (4P) fetal medicine. Fetal. Diagn. Ther.36; 2.Art. 85.

29. Groesch KA, Torry RJ, Wilber AC et al. 2011. Nitric oxide generation affects pro- and anti-angiogenic growth factor expression in primary human trophoblast. Placenta. 32;12:926–931. http://dx.doi.org/10.1016/j.placenta.2011.08.008; PMid:21963217 PMCid:PMC3269960

30. Jang EA, Longo LD, Goyal R. 2015. Antenatal maternal hypoxia: criterion for fetal growth restriction in rodents. Front Physiol. 6.Art. 176. http://dx.doi.org/10.3389/fphys.2015.00176; PMid:26106333 PMCid:PMC4458570

31. Khalil A, Hardman L, Brien PO. 2015. The role of arginine, homoarginine and nitric oxide in pregnancy. Amino. Acids. 47;9:1715–1727. http://dx.doi.org/10.1007/s00726-015-2014-1; PMid:26092522

32. Kovo M, Schreiber L, Elyashiv O et al. 2015. Pregnancy outcome and placental findings in pregnancies complicated by fetal growth restriction with and without preeclampsia. Reprod. Sci. 22;3:316–321. http://dx.doi.org/10.1177/1933719114542024; PMid:25001023

33. Laskowska M, Laskowska K, Leszczyńska-Gorzelak B, Oleszczuk J. 2011. Asymmetric dimethylarginine in normotensive pregnant women with isolated fetal intrauterine growth restriction: a comparison with preeclamptic women with and without intrauterine growth restriction. J. Matern. Fetal. Neonatal. Med. 24;7:936–942. http://dx.doi.org/10.3109/14767058.2010.535873; PMid:21142768

34. Leiva A, Fuenzalida B, Barros E et al. 2016. Nitric oxide is a central common metabolite in vascular dysfunction associated with diseases of human pregnancy. Curr. Vasc. Pharmacol. 14;3:237–259. http://dx.doi.org/10.2174/1570161114666160222115158

35. Mifsud W, Sebire NJ. 2014. Placental pathology in early-onset and late-onset fetal growth restriction. Fetal. Diagn. Ther. 36;2:117–128. http://dx.doi.org/10.1159/000359969; PMid:24577279

36. Neri I, Monari F, Sgarbi L et al. 2010. L-arginine supplementation in women with chronic hypertension: impact on blood pressure and maternal and neonatal complications. J. Matern. Fetal. Neonatal. Med. 23;12:1456–1460. http://dx.doi.org/10.3109/14767051003677962; PMid:20958228

37. Reshef R, Schwartz D, Ingbir M et al. 2008. A profound decrease in maternal arginine uptake provokes endothelial nitration in the pregnant rat. Am. J. Physiol. Heart Circ. Physiol. 294;3:H1156–H1163. http://dx.doi.org/10.1152/ajpheart.01051.2007; PMid:18156200

38. Sankaralingam S, Xu H, Davidge ST. 2010. Arginase contributes to endothelial cell oxidative stress in response to plasma from women with preeclampsia. Cardiovasc. Res. 85;1:194–203. http://dx.doi.org/10.1093/cvr/cvp277; PMid:19684035

39. Salgado MT, Cao Z, Nagababu E et al. 2015. Red blood cell membrane-facilitated release of nitrite-derived nitric oxide bioactivity. Biochemistry 54;44:6712–6723. http://dx.doi.org/10.1021/acs.biochem.5b00643; PMid:26478948

40. Singh S, Singh A, Sharma D et al. 2015. Effect of L-Arginine on nitric oxide levels in intrauterine growth restriction and its correlation with fetal outcome. Indian J. Clin. Biochem. 30;3:298–304. http://dx.doi.org/10.1007/s12291-014-0450-4; PMid:26089616 PMCid:PMC4469053

41. Tikvica A, Kusan Jukić M, Pintarić I, Medić M, Hudicek-Martincić G, Kosec V, Salihagić-Kadić A et al. 2008. Nitric oxide synthesis in placenta is increased in intrauterine growth restriction and fetal hypoxia. Coll. Antropol. 32;2:565–570. PMid:18756911

42. Tranquilli AL, Giannubilo SR, Bezzeccheri V et al. 2004. Amniotic levels of nitric oxide and vascular endothelial growth factor in pregnancy with subsequent intrauterine fetal death. Eur. J. Obstet. Gynecol. Reprod. Biol. 114;2:162–165. http://dx.doi.org/10.1016/j.ejogrb.2003.10.016; PMid:15140509

43. Unterscheider J, O'Donoghue K, Malone FD. 2015. Guidelines on fetal growth restriction: a comparison of recent national publications. Am. J. Perinatol. 32;4:307–316. PMid:25217738

44. Vayssiиre C, Sentilhes L, Ego A et al. 2015. Fetal growth restriction and intra-uterine growth restriction: guidelines for clinical practice from the French College of Gynecologists and Obstetricians. Eur. J. Obstet. Gynecol. Reprod. Biol. 193:10–18. http://dx.doi.org/10.1016/j.ejogrb.2015.06.021; PMid:26207980