SOVREMENNAYA PEDIATRIYA.2016.7(79):60-64; doi 10.15574/SP.2016.79.60

Histamineintolerance syndrome in pediatrician practice

Marushko Y., Moskovenko O. 
National Medical University named after A.A. Bogomolets, Kyiv, Ukraine

In recent years there has been a significant increase in allergic conditions. The clinic is dominated by IgE-independent mechanisms of allergic pathology, which are based on a violation of histamine metabolism in the body. Increased levels of extracellular histamine on the background of decreasing the activity of the enzyme diamine oxidase (DAO) leads Histamineintolerance syndrome (HIT). This state is characterized by a wide variety of clinical manifestations. The most informative method of diagnosis HIT is skin prick test with histamine (Test Histamine-50), which allows you to confirm the low activity of DAO in the body and the need for replacement therapy.

Key words: allergic syndroms, histamine, diamine oxidase (DAO), HIT syndrome, scin prick test (SPT), Test Histamine-50.

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