• Heartburn during pregnancy: reasons and opportunities to improve the quality of life of women during this period 
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Heartburn during pregnancy: reasons and opportunities to improve the quality of life of women during this period 

HEALTH OF WOMAN. 2016.2(108):80–86 
 

Heartburn during pregnancy: reasons and opportunities to improve the quality of life of women during this period 
 

Shcherbinina M. B., Lugovskaya T. V., Ivanchenko N. A.

Dnipropetrovsk national University Oles Honchar

The family Planning center Tamara Lugovskoy, Dnepropetrovsk 
 

Heartburn during pregnancy is a serious clinical problem, as it significantly decreases the quality of life of women. Hormonal theory of heartburn during pregnancy is common today. Hormonal changes, a progressive increase in intra-abdominal pressure and the phenomenon of postprandial acid pocket increase the probability of casting of gastric contents into the esophagus and heartburn development. Modern and safer drugs based on alginic acid provide physiological antireflux effect, displace acid pocket down from lower esophageal sphincter. Thereby they facilitate reflux symptoms of pregnants with heartburn.


Key words: alginates, GERD, heartburn in pregnant women, acid pocket.


REFERENCES

1. Mandel KG, Daggy BP, Brodie DA, Jacoby HI. 2000. Review article: alginate-raft formulations in the treatment of heartburn and acid reflux. Aliment. Pharmacol. Ther. 14:669–690. http://dx.doi.org/10.1046/j.1365-2036.2000.00759.x; PMid:10848650

2. Strugala V, Bassin J еt al. 2012. Assessment of the Safety and Efficacy of a Raft-Forming Alginate Reflux Supressant (Liquid Gaviscon) for the Treatment of Heartburn during Pregnancy. Obstetrics and Gynecology; Article ID 481870: 6, http://dx.doi.org/10.5402/2012/481870.

3. Malfertheiner S, Malfertheiner M, Kropf S. 2012. A prospective longitudinal cohort study: evolution of GERD symptoms during the course of pregnancy. BMC Gastroenterol. 12:131. BMC Gastroenterol. 2012. 12: 131. Published online 2012 Sep 24. http://dx.doi.org/10.1186/1471-230X-12-131.

4. Revicki DA, Wood M, Maton PN et al. 1998. The impact of gastroesophageal reflux disease on health-related quality of life. Am.J. Med. 104:252–258. http://dx.doi.org/10.1016/S0002-9343(97)00354-9

5. Junghard O, Carlsson R, Lind T. 2003. Sufficient control of heartburn in endoscopy-negative gastroesophageal reflux disease trials. Scand. J. Gastroenterol. 38:1197–1199. http://dx.doi.org/10.1080/00365520310004920; PMid:14750636

6. Kahrilas PJ, Shaheen NJ, Vaezi MF et al. 2008. American Gastroenterological Association medical position statement on the management of gastroesophageal reflux disease. Gastroentero-logy. 135:1383–1391. http://dx.doi.org/10.1053/j.gastro.2008.08.045; PMid:18789939

7. Katz PO, Gerson LB, Vela MF. 2013, March. Guidelines for the Diagnosis and Management of Gastroesophageal Reflux Disease. Am J Gastroenterol. 108:308–328. http://dx.doi.org/10.1038/ajg.2012.444http://dx.doi.org/10.1038/ajg.2013.314; PMid:23419381

8. Vakil N, van Zanden SV, Kahrilas P et al. 2006. The Monreal Definition and Classification of Gastroesophageal Reflux Disease: A Global Evidence-Based Consensus. Am. J. Gastroenterol. 101:1900–1920. http://dx.doi.org/10.1111/j.1572-0241.2006.00630.x; PMid:16928254

9. Fisher RS, Roberts GS, Grabowski CJ, Cohen S. 1978. Altered lower esophageal sphincter function during early pregnancy. Gastroenterology. 74;6:1233–1237. PMid:648814

10. Van Thiel DH, Gavaler JS, Joshi SN et al. 1977. Heartburn of pregnancy. Gastroenterology. 72;4(Pt. 1):666–668.

11. Madanick RD, Katz PO. 2006. GERD and Pregnancy. Practical gastroenterology. 29;6:30–39.

12. Richter JE. 2005. Review article: the management of heartburn in pregnancy. Aliment. Pharmacol. Ther. 22:749–757. http://dx.doi.org/10.1111/j.1365-2036.2005.02654.x; PMid:16225482

13. Van Thiel DH, Gavaler JS, Stremple J. 1976. Lower esophageal sphincter pressure in women using sequential oral contraceptives. Gastroenterology 71;2:232–234. PMid:939383

14. Fletcher J, Wirz A, Young J et al. 2001. Unbuffered highly acidic gastric juice exists at the gastroesophageal junction after a meal. Gastroenterology. 121:775–783. http://dx.doi.org/10.1053/gast.2001.27997; PMid:11606490

15. Clarke AT, Wirz AA et al. 2008. Severe reflux disease is associated with an enlarged unbuffered proximal gastric acid pocket. Gut 57:292-297. http://dx.doi.org/10.1136/gut.2006.109421.

16. Boecxstaens V, Bisschops R et al. 2011. Modulation of the postprandial acid and bile pockets at the gastro-oesophageal junction by drugs that affect gastric motility. Aliment Pharmacol Ther, 33:1370-1377. http://dx.doi.org/10.1111/j.1365-2036.2011.04664.x; PMid:21517922

17. ASGE Guideline: guidelines for endoscopy in pregnant and lactating women. Gastrointestinal Endoscopy. 2005. 61;3:357–362. http://dx.doi.org/10.1016/S0016-5107(04)02780-4

18. Katz PO, Castell DO. 1998. Gastroesophageal reflux disease during pregnancy. Gastr. Clin. N. Amer. 27:153–167. http://dx.doi.org/10.1016/S0889-8553(05)70351-4

19. Mandel KG, Daggy BP, Brodie DA et al. 2000. Review article alginate raft formulations in the treatment of heartburn and acid reflux. Aliment. Pharmacol. Ther. 14:3–22. http://dx.doi.org/10.1046/j.1365-2036.2000.00759.x

20. Rohof W, Bennink R et al. 2013. An Alginate-Antacid Formulation Localizes to the Acid Pocket to Reduce Acid Reflux in Patients With Gastroesophageal Reflux Disease. Clinical Gastroenterology and Hepatology 11:1585–1591. http://dx.doi.org/10.1016/j.cgh.2013.04.046; PMid:23669304

21. Kwiatek MA, Roman S et al. 2011. An alginate-antacid formulation (Gaviscon Double Action Liquid) can eliminate the postprandial «acid pocket» in symptomatic GERD patients. Aliment. Pharmacol. Ther. 34(1):59–66. http://dx.doi.org/10.1111/j.1365-2036.2011.04678.x; PMid:21535446 PMCid:PMC3612878

22. Strugala V, Dettmar PW, Sarratt K et al. 2010, Mar–Apr. A Randomized, controlled, crossover trial to investigate times to onset of the perception of soothing and cooling by over-the-counter heartburn treatments. J. Int. Med. Res. 38(2):449–457. http://dx.doi.org/10.1177/147323001003800208; PMid:20515559

23. Chatfield S. 1999. A comparison of the efficacy of the alginate preparation Gaviscon Advance, with placebo in the treatment of gastroesophageal reflux disease. Curr. Med. Res. Opin. 15:152–159. http://dx.doi.org/10.1185/03007999909114086; PMid:10621921

24. Lindow SW, Regnell P, Sykes J et al. 2003. An open_label, multicentre study to assess the safety and efficacy of a novel reflux suppressant (Gaviscon Advance) in the treatment of heartburn during pregnancy. Int. J. Clin. Pract. 57(3):175–179. PMid:12723718

25. Uzan M, Uzan S et al. 1988, Jul-Sep. Heartburn and regurgitation in pregnancy. Efficacy and innocuousness of treatment with Gaviscon suspension. Rev Fr Gynecol Obstet. 83(7–9):569–72. PMid:2848305

26. Mandel KG, Deggy BP, Brody DA, Dzheykoby GI. 2010. Al’gynatsoderhashchye preparati v lechenii gastroezofageal’noy reflyuksnoy bolezny. Consilium Medicum. Ukraina. 2:4–8.

27. Dettmar U, Hempson FCh, Toubel D at al. 2008. Podavlenie gastroezofageal’nogo reflyuksa pry pomoshchy al’gynatov. RMZh. Bolezhy organov pyshchevareniya. 10;2:83–86.