SOVREMENNAYA PEDIATRIYA.2019.2(98):23-30; doi 10.15574/SP.2019.98.22

Senkivska L. I., Biryukov V. S., Aryayev M. L.
Odessa National Medical University, Ukraine

The objective is to study the incidence of growth hormone deficiency (GHD) in children, age of diagnosis and territorial prevalence in various natural physical and geographical zones and biogeochemical provinces in Odessa region.

The study material has been presented by data of examinations the dispensary group of children with GHD, reflected in outpatient cards of endocrinology Center in Odessa Regional Children's Clinical Hospital (ORCCH).

Results. In 2017 62 children with dwarfism, caused by a growth hormone deficiency (GHD) were supervised in the endocrinology center of ORCCH. The prevalence of disease was 1:7384, and total incidence GHD was 13.54 cases per 100,000 children. 62 children with GHD included 47 boys and 15 girls (ratio 3.1:1). Marked heterogeneity of GHD occurrence in the Odessa Region аssociated with places of patient's residence has been revealed. The highest occurrence was found in the following districts: Ananievsk — 1:1828, Mykolayiv — 1:3800, Savran — 1:3887, Reni — 1:4034, Artsiz — 1:4796 and Oknyansk — 1:4915. According to the geochemical and geo-physical mapping, the above-mentioned districts are located on areas which are exposed harmful environmental factors: gravitation and magnetic anomalies; point anomalies contents of uranium, radon, copper, plumbum, mercury, strontium, americium against the depleted content in zinc, molybdenum and cobalt soils; the earth's crust and the structural-tectonic and hydrogeological anomalies.

The conclusion. The study established the existence of DGR+related biogeochemical provinces in the Odessa region. The development of such investigations is promising and justified for improving the strategies of prevention and diagnosis DGR.

Key word: Growth hormone deficiency, morbidity, geographical prevalence, biogeochemical provinces.

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Article received: Nov 09, 2018. Accepted for publication: Mar 12, 2019.