Modern Pediatrics. Ukraine. (2023). 4(132): 85-90. doi 10.15574/SP.2023.132.85
Kravchenko T. Yu., Kopiyka G. K., Zaretska V. V.
Odessa National Medical University, Ukraine

For citation: Kravchenko TYu, Kopiyka GK, Zaretska VV. (2023). Functional dyspepsia in children (literature review). Modern Pediatrics. Ukraine. 4(132): 85–90. doi 10.15574/SP.2023.132.85.
Article received: Mar 04, 2023. Accepted for publication: May 16, 2023.

Functional digestive disorders account for a significant proportion of gastrointestinal diseases in children. In recent years, we have seen the growth of functional dyspepsia in children, which is an urgent problem for both children's gastroenterologists and pediatricians.
Purpose – to conduct a systematic review of the literature on etiopathogenesis, clinical manifestations, laboratory and instrumental studies, as well as methods of treatment and prevention of functional dyspepsia in children.
The scientific literature is analyzed and the data on the complex etiopathogenesis of functional dyspepsia, the multifaceted pathogenetic links, the role of psychoneurological factors are presented. The modern classification of functional dyspepsia in children is given. It should be noted that, despite the widespread prevalence of this pathology, doctors sometimes face significant difficulties at the stage of diagnosis. «Symptoms of anxiety», in the presence of which the diagnosis of functional dyspepsia becomes impossible. According to domestic and international studies, the treatment of functional dyspepsia should be comprehensive, include dietary recommendations, recommendations on regime and lifestyle, and drug therapy.
No conflict of interests was declared by the authors.
Keywords: dyspepsia, children, Roman criteria IV, gastrointestinal tract, treatment.

REFERENCES

1. Belousova OYu, Kazaryan LV. (2019). Funktsionalnaya dispepsiya u detey. Problemyi i perspektivyi simptomaticheskoy terapii. Zdorov'e rebenka. 14 (8): 475-479. https://doi.org/10.22141/2224-0551.14.8.2019.190841

2. Belousova OYu. (2021). Gastroduodenalna patologiya u ditey: scho z neyu robiti? «Gastrotandem 2021». Mizhdistsiplinarniy pidhid do aktualnih pitan gastroenterologiyi. Gastroenterologiya. Gepatologiya. Koloproktologiya. 3 (61): 9-10.

3. Benninga MA, Nurko S, Faure C. (2016). Childhood functional gastrointestinal disorders: neonate/toddler. Gastroenterology. 150 (6): 1443-1455. https://doi.org/10.1053/j.gastro.2016.02.016; PMid:27144631

4. Berezhniy V, Mamenko M, Drokh H et al. (2017). Psycho-emotional disorders and stress conditions correction in children with functional gastrointestinal disorders. Sovremennaya pediatriya. 2 (82): 76-84. https://doi.org/10.15574/SP.2017.82.76

5. Bobrova VI. (2016). Functional and organic pathology of the stomach: the problem of differential diagnosis. Sovremennaya pediatriya. 6 (78): 99-102. https://doi.org/10.15574/SP.2016.78.99

6. Chernyavskiy VV. (2020). Funktsionalna dispepsiya v zagalnosimeyniy praktitsi. Zdorov'ya Ukrayini 21 storichchya. 10 (479): 40-42.

7. Drossman DA, Hasler WL. (2016). Rome IV – Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology. 150 (6): 1257-1261. https://doi.org/10.1053/j.gastro.2016.03.035; PMid:27147121

8. Drossman DA. (2016). Functional Gastrointestinal Disorders: History, Pathophysiology, Clinical Features, and Rome IV. Gastroenterology. 150 (6): 1262-1279. https://doi.org/10.1053/j.gastro.2016.02.032; PMid:27144617

9. Du LJ, Chen BR, Kim JJ et al. (2016). Helicobacter pylori eradication therapy for functional dyspepsia: systematic review and metaanalysis. World J. Gastroenterol. 22: 3486-3495. https://doi.org/10.3748/wjg.v22.i12.3486; PMid:27022230 PMCid:PMC4806206

10. Houghton LA, Heitkemper M, Crowell M et al.  (2016). Age, gender and women's health and patient. Gastroenterology. 150 (6): 1332-1343. https://doi.org/10.1053/j.gastro.2016.02.017; PMid:27144622

11. Hyams JS, Di Lorenzo C, Saps M. (2016). Functional gastrointestinal disorders: child/adolescent. Gastroenterology. 150 (6): 1456-1468. https://doi.org/10.1053/j.gastro.2016.02.015; PMid:27144632

12. Lisitsya YuM, Bulat LM, Pipa LV. (2019). Klinichni maski somatoformnih rozladiv shlunkovo- kishkovogo traktu ta sechovidilnoyi sistemi u ditey, asotsiyovanih z afektivnimi stanami. Visnik Vinnitskogo natsionalnogo medichnogo universitetu. 23 (3): 439-447.

13. Maydannik VG. (2016). Rimski kriteriyi IV (2016): Scho novogo? Mizhnarodniy zhurnal pediatriyi, akusherstva ta ginekologiyi. 10 (1): 8-18.

14. Moayyedi P, Lacy EB, Andrews CN. (2017). ACG and CAG Clinical Guideline: Management of dyspepsia. The American Journal of Gastroenterology. 112: 988-1013. https://doi.org/10.1038/ajg.2017.154; PMid:28631728

15. MOZ Ukrayini. (2013). Unifikovaniy klinichniy protokol medichnoyi dopomogi dityam z funktsionalnoyu dispepsieyu. Nakaz MOZ Ukrayini vid 29.01.2013 r. No. 59. (Pereglyad vid 15.07.2016 r. No. 723). https://zakon.rada.gov.ua/rada/show/v0059282-13/print#n1089.

16. Ortiz AM, Cooper CJ, Gomez Y. (2015). Clinical Experience and Cardiovascular Safety Profile of Domperidone Therapy for Nausea and Vomiting. Am J Med Sci. 349 (5): 421-424. https://doi.org/10.1097/MAJ.0000000000000439; PMid:25828198 PMCid:PMC4418779

17. Paliy IG, Barannikov KV. (2013). Suchasniy poglyad na diagnostiku ta likuvannya funktsionalnoyi dispepsiyi. Praktikuyuchiy lIkar. 2: 87-92.

18. Paliy IG. (2013). Funktsionalna dispepsiya: suchasni uyavlennya pro mehanizmi viniknennya y taktiku vedennya patsientiv. Praktikuyuchiy likar. 3: 25-30.

19. Saltikova GV. (2019). Zahvoryuvannya verhnogo viddilu travnogo kanalu u ditey, problemi diagnostiki kriz prizmu suchasnih Evropeyskih rekomendatsIy. Mizhnarodniy zhurnal pediatriyi, akusherstva ta ginekologiyi. 13 (2): 14-19.

20. Schmulson MJ, Drossman DA. (2017). What is new in Rome IV. J Neurogastroenterol Motil. 30 (23): 151-163. https://doi.org/10.5056/jnm16214; PMid:28274109 PMCid:PMC5383110

21. Solovyova GA. (2021). Suchasni rekomendatsiyi z diagnostiki ta likuvannya funktsionalnoyi dispepsiyi. Zdorov'ya Ukrayini 21 storichchya. 10 (503): 60-61. https://doi.org/10.1016/j.kine.2021.06.004

22. Stanghellini V, Chan FCL, Hasler WL.  (2016). Gastroduodenal disorders. Gastroenterology.  150 (6): 1380-1392. https://doi.org/10.1053/j.gastro.2016.02.011; PMid:27147122

23. Sugano K, Tack J, Kuipers EJ. (2015). Kyoto global consensus report on Helicobacter pylori gastritis. Gut. 64 (9): 1353-1367. https://doi.org/10.1136/gutjnl-2015-309252; PMid:26187502 PMCid:PMC4552923

24. Sіrchak ES. (2016). Funktsіonalna dispepsіya u prizmі Rimskih kriteryiv IV. Gastroenterologiya, gepatologiya, koloproktologiya. 3 (41): 5-6.

25. Tkach S.M. (2016). Prakticheskie podhodyi k vedeniyu bolnyih s dispepsiey. Gastroenterologiya. 1 (59): 81-85. https://doi.org/10.22141/2308-2097.1.59.2016.74534

26. Tkach SM, Dorofeev AE, Harchenko NV. (2022). Suchasni poglyadi na mehanizmi patogenezu i taktiku vedennya hvorih iz perehrestom simptomiv funktsionalnoyi dispepsiyi ta sindromu podraznenogo kishechnika. Oglyad literaturi. Suchasna gastroenterologiya. 1-2 (123-124): 63-75. https://doi.org/10.30978/MG-2022-1-63

27. Tkach SМ. (2016). Functional Dyspepsia in the Light of the Rome IV Criteria. Gastroenterology. 4 (62): 65-71. doi: 10.22141/2308- 2097.4.62.2016.81097.

28. Voloshin KV, Kovalivska SO, Krutenko NV. (2021). Analiz strukturi patologiyi organiv shlunkovo-kishkovogo traktu u ditey. Aktualni problemi suchasnoyi meditsini. 8: 22-31. https://doi.org/10.26565/2617-409X-2021-8-02

29. Wauters L, Dickman R, Drug V et al. (2021). United European Gastroenterology (UEG) and European Society for Neurogastroenterology and Motility (ESNM) consensus on functional dyspepsia. United European Gastroenterol J. 9 (3): 307-331. https://doi.org/10.1002/ueg2.12061; PMid:33939891 PMCid:PMC8259261

30. Zharikova YuV. (2022). Likuvannya funktsionalnoyi dispepsiyi. Mizhdistsiplinarniy pidhid. Ukrayinskiy medichniy chasopis. 4: 150.