PERINATOLOGIYA I PEDIATRIYA.2015.4(64):111-114; doi 10.15574/PP.2015.64.111 
 

Features thyroid abnormalities in children with obesity 
 

Shushlyapina O. V., Budreyko O. A.

SI «Institute of children and adolescents health care of national academy of medical sciences», Kharkiv 
 

Purpose — to explore the features of thyroid abnormalities in children with obesity. 
 

Patients and methods. In 121 patients with obesity 6–16 years on the basis of a comprehensive survey carried out identification thyropathies (diffuse nontoxic goiter, autoimmune thyroiditis and heterogeneity of the structure of the thyroid gland without increasing the volume and the absence of anti-thyroid antibodies). With the ratio of TSH/FT4 it was defined condition minimum thyroid insufficiency (TSH/FT4 within 0.19–0.29) and subclinical hypothyroidism (TSH/FT4>0.29). Patients were grouped by gender (51 girl and 70 boys) and age according to the stage of puberty (I group — pre-puberty, II group — early puberty, III group — puberty). 
 

Results. The most common thyropathies obese children is diffuse nontoxic goiter (31.2%). Autoimmune thyroiditis was diagnosed in 3.9% of children and 7.5% heterogeneity of the structure of the thyroid gland. The whole group was higher level TTG 4.0 mIU/ml and 17.3% was the highest in I group (3.2±1.4 mIU/mL), especially boys (3.1±1.7 mIU/mL), and was observed more frequently in patients with autoimmune thyroiditis (3.2±1.5 mIU/ml anti 2.8±0.8 mIU/ml in the controls, p<0.1) and obese children and heterogeneity of the structure of the thyroid gland (3.0±1.5 mIU/ml). Minimum thyroid insufficiency was found in all groups of patients, usually — in prepubertal age (36.3%) and in the presence of autoimmune thyroiditis and heterogeneity of the structure of the thyroid gland (33.3%). 
 

Conclusions. The most vulnerable period for the occurrence of thyroid dysfunction is the prepubertal period, especially in boys, which requires monitoring thyroid function in patients with obesity, especially younger and male. Heterogeneity of the structure of the thyroid gland children with obesity, even in the absence of other signs of autoimmune thyroiditis, can be considered a risk factor for thyroid insufficiency, which requires constant monitoring of the functional state of the thyroid gland in these patients. 
 

Key words: obesity, thyropathies, children and adolescents. 
 

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