- Features of subjective manifestations, staging of neoplasia of the genitals in the postmenopausal рeriod
Features of subjective manifestations, staging of neoplasia of the genitals in the postmenopausal рeriod
HEALTH OF WOMAN. 2019.3(139): 77–80; doi 10.15574/HW.2019.139.77
Garashova M. A.
Azerbaijan Medical University, Baku
The objective: to determine the structure, the stage of detecting ,the severity of subjective manifestations in the presence of tumor processes of the reproductive organs.
Materials and methods. A retrospective analysis of case histories of 301 patients with tumors of the reproductive organs in the postmenopausal period was carried out. The average age of patients was 61.6±0.4 years. The duration of the postmenopausal period ranged from 11.0±0.6 years.
Results. It was established that 28.9% of postmenopausal women have uterine fibroids, 29.4% have endometrial hyperplasia, 21.6% have endometrial cancer, 10.6% – ovarian cancer, 5.6% – benign ovarian tumors, 5.6% – cervical cancer, 1.7% of patients have uterine sarcoma.
In 68.8% of patients, ovarian cancer is diagnosed in the late stages with a predominance of disease detection at stage III of the tumor process (62.5%). Endometrial cancer is diagnosed in 86.2% of patients in the early stages of the tumor process. The frequency of diagnosis of endometrial cancer in the later stages is 4.6%.
From the clinical manifestations of genital tumors in postmenopausal, vaginal bloody discharge and/or bleeding, abdominal pain, rapid heartbeat and excessive body hair growth predominate.
Conclusion. The results obtained allowed to establish that the postmenopausal period is a period of high risk for the development of neoplastic processes of the reproductive organs.
Key words: genital tumors, postmenopausal period, endometrial cancer, ovarian cancer, uterine myoma, uterine sarcoma, endometrial hyperplasia.
REFERENCES
1. Bochkareva NV, Kolomiets LA, Kondakova IV, Muntyan AB. 2009. Otsenka riska razvitiya raka endometriya u bolnyih s giperplasticheskimi protsessami endometriya i miomoy matki v razlichnyie vozrastnyie periodyi. Zhurn. «Opuholi zhenskoy reproduktivnoy sistemy» 1: 102–107.
2. Davyidov AI, Kryizhanovskaya OV. 2009. Giperplasticheskie protsessyi endometriya: kontseptualnyie voprosyi diagnostiki i lecheniya. Voprosyi ginekologii, akusherstva i perinatologii 8;2: 77–82.
3. Klinyishkova TV, Frolova NB, Mozgovoy SI. 2010. Kliniko-morfologicheskoe obosnovanie optimizatsii lecheniya bolnyih s giperplaziey endometriya. Rossiyskiy vestnik akushera-ginekologa 3:16–20.
4. Baird DD, Hill MC, Schectman JM, Hollis BW. 2013. Vitamin D and the risk of uterine fibroids. Epidemiology 24: 447–453. https://doi.org/10.1097/EDE.0b013e31828acca0; PMid:23493030 PMCid:PMC5330388
5. Bowden W, Skorupski J, Kovanci E, Rajkovic A. 2009. Detection of novel copy number variants in uterine leiomyomas using high resolution SNP arrays. Molec. Hum. Reprod. 15;9:563–568. https://doi.org/10.1093/molehr/gap050; PMid:19567454 PMCid:PMC2725754
6. Brinton LA, Sakoda LC, Lissowska J, Sherman ME, Chatterjee N. 2007. Reproductive risk factors for endometrial cancer among Polish women. Br.J.Cancer. 96: 1450–1456. https://doi.org/10.1038/sj.bjc.6603731; PMid:17426703 PMCid:PMC2360184
7. Hildebrand JS, Gapstur SM, Feigelson HS, Teras LR. 2010. Postmenopausal hormone use and incident ovarian cancer: Associations differ by regimen. Int.J.Cancer. 127: 2928–2935. https://doi.org/10.1002/ijc.25515; PMid:21351271
8. Kho KA, Lin K, Hechanova M, Richardson DL. 2016. Risk of Occult Uterine Sarcoma in Women Undergoing Hysterectomy for Bening Indications. Am.J.Obstet.Gynecol. 127;3: 468–473. https://doi.org/10.1097/AOG.0000000000001242; PMid:26855091 PMCid:PMC5817881
9. Laughlin SK, Schroeder JC, Baird DD. 2010. New directions in the epidemiology of uterine fibroids. Seminars in Reproductive Medicine 28;3: 204–217. https://doi.org/10.1055/s-0030-1251477; PMid:20414843 PMCid:PMC5330647
10. Lieng M, Qvigstad E, Sandvik L et al. 2007, Apr. Hysteroscopic resection of symptomatic and asymptomatic endometrial polyps. J.Minim Invasive Gynecol. 14 (2):189–94. https://doi.org/10.1016/j.jmig.2006.09.018; PMid:17368255
11. Lu L, Risch H, Irwin ML, Mayne ST. 2011. Long-term overweight and weight gain in early adulthood in association with risk of endometrial cancer. Int.J.Cancer. 129: 1237–1243. https://doi.org/10.1002/ijc.26046; PMid:21387312 PMCid:PMC3125463
12. Ma X, Zhao LG, Sun JW, Yang Y. 2015. Association between breastfeeding and risk of endometrial cancer: a meta-analysis of epidemiological studies. Eur.J.Cancer.Prev.
13. Pennant ME, Mehta R, Moody P, Hackett G, Prentice A. 2017. Premenopausal abnormal uterine bleeding and risk of endometrial cancer. BJOG. 124: 404–411. https://doi.org/10.1111/1471-0528.14385; PMid:27766759 PMCid:PMC5297977
14. Saldana TM, Moshesh M, Barid DD. 2013. Self-reported family history of leiomyoma: not a reliable marker of high risk. Annals of Epidemiology 23;5: 286–290. https://doi.org/10.1016/j.annepidem.2013.03.003; PMid:23621994 PMCid:PMC5384608
15. Wu AH, Pearce CL, Tseng CC, Templeman C. 2009. Markers of inflammation and risk of ovarian cancer in Los Angeles County. Int.J.Cancer. 124: 1409–1415. https://doi.org/10.1002/ijc.24091; PMid:19065661 PMCid:PMC4203374