- Features of the neurohumoral status in women with arterial hypertension and diastolic dysfunction depending on body weight
Features of the neurohumoral status in women with arterial hypertension and diastolic dysfunction depending on body weight
HEALTH OF WOMAN. 2019.8(144): 64–67; doi 10.15574/HW.2019.144.64
N.M. Kyrychenko
Sumy State University
Obesity is associated with inflammation, arterial hypertension, diabetes mellitus, dyslipidemia and increased risk of cardiovascular disease. A structural changes of the left ventricle in obesity leads to diastolic dysfunction and, finally, to systolic dysfunction and heart failure.
The objective: to study the characteristics of neurohumoral status in women with arterial hypertension and diastolic dysfunction, depending on body mass index.
Materials and methods. 101 patients were examined. Patients were divided into groups according to BMI: group I consisted of 20 patients with a BMI of up to 25 kg/m2, group II included 22 people with a BMI of 30.0 kg/m2 and 34.9 kg/m2, group III – 34 patients with a BMI from 35.0 kg/m2 to 39.9 kg/m2, group IV consisted of 25 patients with a BMI of more than 40 kg/m2. The study involved female patients aged 40–60 with hypertension 2 of II–III degree, impaired relaxation and preserved ejection fraction. All groups of patients had a comprehensive clinical, laboratory and ultrasound examination. Statistical processing was carried out by Statistica for Windows version 6.0.
Results. Patients with normal weight had significantly (p<0.05) lower levels of atherogenic lipoproteins and triglycerides than patients with obesity. Individuals with OB 3 had significantly (p<0.05) higher levels of total cholesterol, triglycerides and LDL than patients from groups I–III. Significant (p<0.05) differences in adipokine levels were also determined: the growth of leptin and the decrease of adiponectin with an increase in patient body weight. Indicators of pro-inflammatory activity in patients with OB 3 were significantly (p<0.05) higher than in patients with normal body weight, as well as compared with OB 1–2. Moreover, the levels of these indicators in patients with obesity of 1 and 2 degrees did not significantly differ between groups.
Conclusions. Women with AH II–III, obesity of the I-III degree and diastolic dysfunction have a significant decrease in the blood content of adiponectin which observed in a BMI of more than 39.9 kg/m2, while the increase in leptinemia is proportional from I to III degree of obesity with the maximum levels in individuals with a BMI of more than 39.9 kg/m2, also in these individuals there is a significant increase in atherogenic lipid fractions and an increase in blood levels of systemic inflammatory response factors.
Key words: obesity, diastolic dysfunction, arterial hypertension.
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