Perinatology and pediatric.Ukraine. 2017.4(72):49-53; doi 10.15574/PP.2017.72.49

Vorobjova I. I., Zhivetska-Denisova A. A., Rudakova N. V., Tkachenko V. B., Tolkach S. M., Nakvasiuk T. S.
SI «Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine», Kyiv, Ukraine

Objective: to explore the characteristics of local immunity in pregnant women with miscarriage compared to healthy pregnant women.
Material and methods. During the study 70 pregnant women were examined. The main group consisted of 50 pregnant women with a history of miscarriage, the control group — 20 apparently healthy women with a physiological gestation course. The study was conducted during the first trimester of pregnancy. The main characteristic features of local immunity such as changes of cervical mucus, cytokine status of cervicovaginal swab and local microbiocenosis of vaginal secretion were examined in all pregnant women of both main and control groups.
Results. Changes of the parameters of immunoglobulin concentration in cervical mucus, imbalance of pro- and anti-inflammatory cytokines in cervical-vaginal swabs in women occur depending on the vaginal microbiocenosis status and are considered as the markers of the local inflammatory process in women with miscarriage.
Conclusions. The miscarriage in women with the altered vaginal microbiocenosis occurs against the background of impaired immune status mainly at the local level.
Key words: pregnancy, miscarriage, cytokines, biotope.

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