PERINATOLOGIYA AND PEDIATRIYA.2019.2(78):19-26; doi 10.15574/PP.2019.78.19

Tumanova L. E., Kolomiets O. V., Ryabenko O. P., Molchanova O. O.
SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician O.M. Lukyanova NAMS of Ukraine», Kyiv
Reproductive Clinic «Nadiya», Kyiv, Ukraine

Purpose — to study the peculiarities of childbirth and the state of newborns in women with infertility of endocrine and inflammatory genesis in history, depending on the method of fertilization.

Patients and methods. The study of the course of labor was carried out in three groups (six subgroups): Group I — pregnant women, history of endocrine infertility: Ia — 50 patients after IVF, Ib — 50 patients who became pregnant themselves after conservative and surgical treatment of infertility, but without IVF; Group II — pregnant women with a history of infertility of inflammatory genesis: ІІа — 100 patients after IVF, IIb — 100 patients who became pregnant independently after conservative and surgical treatment of infertility, but without IVF; Group III — pregnant women with a history of combined infertility, inflammatory origin with endocrine, ІІІa — 30 patients after IVF, IIIb — 30 patients who became pregnant independently after conservative and surgical treatment of infertility, but without IVF.

Results. Analyzing the timing of the onset of labor in women of the examined groups, attention is drawn to the fact that every fourth pregnancy in the first group and every third in group III ended in preterm labor, regardless of the method of fertilization. This testifies to the significant impact of both endocrine and inflammatory factors in the history of infertility, miscarriage. In all groups surveyed, the percentage of operative delivery was high: 50–70% in Group I, 60–70% in Group II, 67–83% in Group III. This is due to both the long_term burdened obstetric and gynecological history, and a large percentage of multiple pregnancies, both after IVF and after administration of drugs to stimulate ovulation in women with endocrine and combined infertility in history. Attention is drawn to the fact that the method of fertilization was more influenced by the method of fertilization, and not by the factor of infertility. Postpartum complications in women with various forms of infertility in history, were also not uncommon. So, anemia after childbirth was encountered in every third woman of the third group, every fourth — in the second and in every fifth — in the first group. Inflammatory after birth complications: pyelonephritis, subinvolution of the uterus, lochiometer, endometritis were more often women in women with groups II and III who had a history of genital infections.

Conclusions. Thus, the course of childbirth and the condition of newborns in women with infertility of various genesis in history is accompanied by a high frequency of obstetric complications, namely, premature birth, premature amniotic fluid, low birth activity, high frequency of operative delivery, low birth weight, postpartum complications , which depended not only on the factor of infertility, but also on the method of fertilization.

Key words: childbirth, condition of newborns infertility, IVF, fertilization method.

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Article received: Jan 21, 2019. Accepted for publication: Jun 11, 2019.