• Factors of aggressive cholesteatoma in children fnd adolescents with chronic suppurative otitis media
en To content Full text of article

Factors of aggressive cholesteatoma in children fnd adolescents with chronic suppurative otitis media

SOVREMENNAYA PEDIATRIYA.2016.1(73):49-53; doi10.15574/SP.2016.73.49

Factors of aggressive cholesteatoma in children fnd adolescents with chronic suppurative otitis media

Kokorkin D. N. 
State institution Zaporozhye Medical Academy of Postgraduate Education, Ministry of Health, Department of Otorhinolaryngology

Objective: To identify clinically relevant factors of aggressive cholesteatoma in children and adolescents with chronic suppurative otitis media.

Materials and methods: 170 patients were operated. Cholesteatoma manifestations were compared in three age groups: children 4–12 years (n=50), adolescents 15–18 years (n=50), adult patients 20–65 years of age (n=70). We studied the influence of various factors on the emergence of aggressive cholesteatoma. The degree of influence of the factors evaluated pair and rank correlation (Spearmen). Use the software «STATISTICA- 6».

Results and discussion. The most important factor in the development of cholesteatoma — is the time factor. The younger the sick child, the more devastating effects of cholesteatoma. Children stages of the disease is inversely proportional to depend on the extent of the cholesteatoma and the number of its complications. For adolescents and adults with chronic otitis characterized by a direct correlation. In children and adolescents aggressive cholesteatoma manifested in the developed cellular structure of the mastoid process. For adult patients inhibits the spread of cholesteatoma sclerotic mastoid, preventing its wide dissemination. The associated pathology of the nose, nasopharynx and paranasal sinuses affects on the development of cholesteatoma. On the prevalence of cholesteatoma complications and the formation of nasal pathology affects differently. For children and adolescents in an inversely proportional and adult patients in the right proportion.

We have studied the background state as a factor of cholesteatoma. In our studies, autonomic dysfunction revealed only 18% of adolescents, with significant impact on the prevalence of cholesteatoma complications and the formation they are not provided. The most serious complications of cholesteatoma we found in children and adolescents with chromosomal abnormalities, median cleft face and insulin-dependent diabetes mellitus. Under these conditions, reliably predict the morphological and functional result of the operation was not possible.

Conclusion. The above factors must be considered during the determining the time of surgery in children and adolescents with chronic suppurative otitis media.

Key words: chronic otitis, cholesteatoma, children, adolescents.

REFERENCES 
1. Veremeyenko KN, Sushko YA, Srebnyak IA, Kizim AI, Borisenko ON. 2004. The activity of enzyme systems in the cholesteatoma of the middle ear. Zhurn vushnyh, nosovych i gorlovych hvorob 3: 145-146. 
2. Bereznuk VV. 2001. Recurrent cholesteatoma ear. Verbatim report of the round table. Zhurn vushnyh, nosovych i gorlovych hvorob. 1: 77-81. 
3. Vlasov GV. 2005. Clinical and immunological characteristics and features of the surgical treatment of children with otitis holesteatomno-destructive. Author diss Cand mednauk. St Petersburg: 16. 
4. Gusakov AD. 2001. Recurrent cholesteatoma ear. Verbatim report of the round table. Zhurn vushnyh, nosovych i gorlovych hvorob. 1: 77-81. 
5. Drozdov MV. 2010. Lifoproliferativ syndrome in children with upper respiratory tract disease (etiology, pathogenesis, clinical and laboratory diagnosis). Author diss Doctor med nauk. St Petersburg: 40. 
6. Bogomilsky MR, Rakhmanov IV, Radtsig EY, Polunin MM. 2006. The value of active audiological examination of infants in the detection and prevention of hearing disorders. Vestnik otorinolaringologii. 1: 49-50. 
7. Ivoylov AY. 2009. Chronic suppurative otitis media in children: current understanding of the pathogenesis, diagnosis, treatment and prevention. Author diss Doctor med nauk. Moscow: 40. 
8. Portman M. 2001. Recurrent cholesteatoma ear. Verbatim report of the round table. Zhurn vushnyh, nosovych i gorlovych hvorob. 1: 77-81. 
9. Sambulov VI. 2004. Modern aspects of diagnosis and surgical treatment of chronic suppurative otitis media in children: Author diss Doctor med nauk. Moscow: 40. 
10. Srebnyak IA, Kizim AI. 2002. The study of the activity of alkaline phosphatase and acid phosphatase in biological fluids and tissues perifocal middle ear in patients with chronic suppurative otitis media. Zhurn vushnyh, nosovych i gorlovych hvorob. 3: 44-49. 
11. Sushko YA. 2001. Recurrent cholesteatoma ear. Verbatim report of the round table. Zhurn vushnyh, nosovych i gorlovych hvorob. 1: 77-81. 
12. Sushko YA, Borisenko ON, Srebnyak IA, Kizim AI, Prokopenko EE, Juice VT. 2011. Cholesteatoma of the middle ear in the age aspect. Zhurn vushnyh, nosovych i gorlovych hvorob 3: 211-212. 
13. Milewski C, Fedorowski A, Stan AC, Walter GF. 1998. Basic fibroblast growth factors (b-FGF) in the perimatrix cholesteatoma. HNO. 46: 804—808. http://dx.doi.org/10.1007/s001060050316; PMid:9816534 
14. Gundersen T, Tonning F, Kveberg K. 1984. Ventilating tubes in the middle ear. Long term observation. Arch Otolaryngol. 110; 12: 783—784. http://dx.doi.org/10.1001/archotol.1984.00800380013004; PMid:6542349 
15. Hildmann H, Sudhoff H. 1999. Cholesteatoma in children. Int Jornal Ped Otolaryngol. 49: 81-86. http://dx.doi.org/10.1016/S0165-5876(99)00138-X 
16. Jahnke K. 2004. Middle ear surgery. Georg Thieme Verlag. Stuttgart: 164. 
17. Meyer W, Krebs A. 1998. Ist die Chirurgie der inneren Nase vor Tympanoplastik indiziert? Laryngol Otol. 77: 682—688. http://dx.doi.org/10.1055/s-2007-997224; PMid:10036670 
18. Sade J, Fuchs C. 1994. A comparisoncomparison of mastoid pneumatization in adults and children with cholesteatoma. Eur Arch Otorhinolaryngol. 251(4): 191—195. http://dx.doi.org/10.1007/BF00628421; PMid:7917249 
19. Saleh HA, Mills RP. 1999. Classification and staging of cholesteatoma. Clin Otolaryngol. 24: 355—359. http://dx.doi.org/10.1046/j.1365-2273.1999.00272.x; PMid:10472474 
20. Tos M, Poulsen G. 1987. Attic retractions following secretory otits. Acta Otolaryngol. 89(56): 479—486.

Содержание журнала Full text of article