Journal Health of Woman. 2025. 6(181): 56-62. doi: 10.15574/HW.2025.6(186).5662
Рrуlutska A. B., Martynova L. I., Ostashevska V. S., Govsіeіev D. О.
Bogomolets National Medical University, Kyiv, Ukraine

For citation: Рrуlutska AB, Martynova LI, Ostashevska VS, Govsіeіev DО. (2025). Experimental justification of the use of enterosorption detoxification in pregnant women with diseases of the hepatobiliary system. Ukrainian Journal Health of Woman. 6(181): 56-62. doi: 10.15574/HW.2025.6(186).5662
Article received: Sep 29, 2025. Accepted for publication: Nov 20, 2025.

Аim – to evaluate and compare the sorption properties of carbon and chitin enterosorbents with respect to bile components under experimental conditions.
Materials and methods. The work used experimental studies of bile from 56 pregnant women with diseases of the hepatobiliary system, where the sorption capacity of carbon and chitin sorbents in relation to bile acids, cholesterol, bilirubin was studied. The sorption value of carbon and chitin sorbents was studied depending on the corresponding concentration of bile acids and bilirubin – with subsequent statistical processing of the results obtained
Results. Analysis of the results of the conducted studies showed the presence of sorption and detoxification properties of both carbon sorbents and chitin sorbents for bilirubin, bile acids, cholesterol, which coincides with the literature data. It should be noted that under experimental conditions, when diluting bile, the sorption efficiency increased in both sorbents, which indicates the peculiarities of the interaction of sorbents in more concentrated environments. Regardless of the experimental conditions, chitin sorbents demonstrated higher rates of bile acid adsorption. A similar trend was observed for cholesterol. As for bilirubin, the difference was less pronounced, but remained statistically significant. The presence of greater sorption properties in the chitin sorbent is probably associated with its chemical structure and ability to electrostatic interactions.
Conclusions. Based on experimental research, it was determined that both carbon sorbents and chitin sorbents have sorption and detoxification properties for bile components, but the sorption efficiency of the chitin sorbent was superior to that of the carbon sorbent, probably due to its chemical structure and ability to electrostatic interactions..
The authors declare no conflict of interest.
Keywords: hepatobiliary system diseases, pregnancy, obstetrics, carbon sorbent, chitin sorbent.

REFERENCES

1. Benyuk SV. (2015). Intrahepatic cholestasis of pregnancy. The consequences for the fetus and newborn. Health of woman. 2(98): 62-64. https://doi.org/10.15574/HW.2015.98.62

2. Bichevska RH, Loskutova IV, Matsiukh NV. (2018). Likuvannia zhinok iz khronichnymy zakhvoriuvanniamy pechinky ta zhovchovyvidnykh shliakhiv pry nevynoshuvanni vahitnosti. Fitoterapiia. (1): 8-12.

3. Boichuk AG. (2014). Stan hepatobiliarnoi systemy i reproduktyvne zdorov'ia zhinky. Zbirnyk naukovykh prats Asotsiatsii akusheriv-hinekolohiv Ukrainy. (1-2): 341-346.

4. Boichuk OH, Nsed ENE, Dubetskyi BI. (2020). Osoblyvosti perebihu vahitnosti u zhinok iz nepliddiam na tli vnutrishnopechinkovoho kholestazu. Aktualni pytannia pediatrii, akusherstva ta hinekolohii. (1): 68-73. https://doi.org/10.11603/24116-4944.2020.1.11488

5. Bolukbas FF, Bolukbas C, Balaban HY, Aygun C, Ignak S, Ergul E et al. (2017). Intrahepatic cholestasis of pregnancy: spontaneous vs in vitro fertilization. Euroasian journal of hepato-gastroenterology. 7(2): 126. URL: https://pmc.ncbi.nlm.nih.gov/articles/PMC5670254/. https://doi.org/10.5005/jp-journals-10018-1232; PMid:29201793 PMCid:PMC5670254

6. Bondarev YeV, Shtryhol SIu, Diriavyi SB. (2008). Zastosuvannia enterosorbentiv u medychnii praktytsi. Provizor. Kharkiv: NFaU, No.13. URL: http://www.provisor.com.ua/archive/2008/N13/enters__138.php?part_code=62&art_code=66 92.

7. Borodin YuI, Konenkov VI, Parmon VN ta in. (2014). Biolohichni vlastyvosti sorbentiv ta perspektyvy yikh zastosuvannia. Uspikhy suchasnoi biolohii. 134(3): 239-240.

8. Coppa GV, Bruni S, Zampini L. (2000). Chitosan per os: From Dietary Supplement to Drug Carrier. Eds: Muzzarelli Riccardo A.A. Italy: Atec: 325.

9. Fedortsiv OIe. (1998). Enterosorbtsiia, yak metod detoksykatsii orhanizmu. Liky. 2: 33-37.

10. Golyanovskyy OV, Juravlyova LA, Savonik AO. (2016). The course of pregnancy, childbirth and postpartum period in women with diseases of the hepatobiliary system. Perinatologiya i pediatriya. 3(67): 23-27. https://doi.org/10.15574/PP.2016.67.23

11. Golyanovsky OV, Mamchych VI, Chaika MO, Slobodian YuV. (2018). Hepatobiliary pathology in pregnancy – obstetric aspects. Health of woman. 2(128): 19-21. https://doi.org/10.15574/HW.2018.128.19

12. Hanytkevych YaV, Karbach YaY. (1985). Yssledovanye zhelchy. Byokhymycheskye y byofyzycheskye metodы. Kyev: «Vyshcha shkola»: 135.

13. Herashchenko II. (2014). Enterosorbenty: likarski zasoby i diietychni dobavky. Kyiv: Natsionalna Akademiia nauk Ukrainy, Instytut khimii poverkhni im. O.O. Chuika: 249.

14. Hromashevskaia LL, Kasatkyna MH, Neborachko VS. (1982). Metodycheskye rekomendatsyy po opredelenyiu zhelchnыkh kyslot, kholesteryna, kholatokholesterynovoho koeffytsyenta zhelchy. Kyev: 14.

15. Hryhoreva NA, Ermolaeva EY, Hlukhova TN. (2015). Dynamycheskye yzmenenyia lypydnoho spektra krovy pry fyzyolohycheskom techenyy hestatsyy u pervorodiashchykh razlychnikh vozrastnikh hrupp. Ynnovatsyon. nauka. 11: 214.

16. Ischenko AI, Demenina NK, Pupisheva TI. (2015). Intrahepatic cholestasis of pregnancy. Health of woman. 6(102): 45-47.

17. Loskutova IV, Bichevska RH. (2017). Lipidnyi spektr krovi u vahitnykh zi zvychnym nevynoshuvanniam u rannomu termini pry khronichnykh zakhvoriuvanniakh pechinky. Sciences of Europe. 20(1): 72-76.

18. Loskutova IV. (2021). Osoblyvosti imunopatohenezu ta imunokorektsii u zhinok z nevynoshuvanniam vahitnosti na foni khronichnykh zakhvoriuvan hepatobiliarnoi systemy. Dysertatsiia.

19. Loskutova IV, Bichevska RH. (2017). Aktyvnist fermentiv tsytolitychnoho syndromu u zhinok zi zvychnym nevynoshuvannia vahitnosti v ranni terminy. Norwegian Journal of development of the International Scienet. 11; 1: 38-41. https://doi.org/10.5894/rh38n1-d5

20. Loskutova IV, Bichevska RH et al. (2021). Changes in the cytokine status in women with chronic liver pathology during reproductive losses in the first trimester. Reproductive Endocrinology. 4(60): 60-66. https://doi.org/10.18370/2309-4117.2021.60.60-66

21. Maslova GV, Krasavtsev VE. (1998). Use of electrochemically extracted chitin in medicine and industry. Proc. of the third Asia-Pacific Chitin and Chitosan Symp. "Advances in chitin science". Taiwan: Republic of China. 3: 443-446.

22. Medved VY, Hrytsai YN, Yslamova AO. (2015). Narushenye funktsyy pecheny u beremennikh: vlyianye na techenye beremennosty, sostoianye ploda y yskhod rodov. Zdorov'ia Ukrainy. 2(18): 24-26.

23. Mintser AP. (2018). Statisticheskie metodyi issledovaniya v klinicheskoy meditsine. Prakticheskaya meditsina. 3: 41-45.

24. Polishchuk IP, Henyk NI, Zhukuliak OM, Bihun RV, Perkhulyn OM. (2024, Jun). Funktsionalnyi stan pechinky u vahitnykh z hipotonichnoiu dyskineziieiu zhovchnykh shliakhiv. The 25th International scientific and practical conference "Universities and schools: methods of distance learning" (June 25-28, 2024) Boston, USA. International Science Group. 2024: 116.

25. Ponomarova OV, Pivniuk VM, Nosko MM ta in. (2008). Profilaktyka za dopomohoiu vuhletsevoho enterosorbentu hostroi ta vidstrochenoi emetohennoi toksychnosti khimioterapevtychnoho likuvannia onkolohichnykh khvorykh. Onkolohyia. 10(3): 370-373.

26. Рrуlutska AB, Martynova LI, Kisilenko ОL, Tsema TА, Govsіeіev DО. (2025). Obstetric aspects of diseases of the hepatobiliary system. Ukrainian Journal of Perinatology and Pediatrics. 1(101): 111-116. https://doi.org/10.15574/PP.2025.1(101).111116

27. Samohalska O, Khlibovska O, Vorontsova T. (2023). Otsinka yakosti zhyttia u vahitnykh iz zakhvoriuvanniamy hepatobiliarnoi systemy. Suchasna medytsyna, farmatsiia ta psykholohichne zdorovia. 2(11): 23-27.

28. Tovstanovskaia VO, Prylutska AB, Horovoi LF. (2000). Perspektyvi yspolzovanyia khytynovikh preparatov v akusherskoi praktyke Vrachebnoe delo. 7-8: 104-108.