HEALTH OF WOMAN. 2019.1(137):64–68; doi 10.15574/HW.2019.137.64

Romanenko T. G., Zhaloba G. М., Staselovych L. Yu., Dovbnia T. V.
Shupyk National Medical Academy of Postgraduate Education MH of Ukraine, Kiev

The article presents modern data on the needs of pregnant women and fetuses in vitamins and microelements and the appropriateness and necessity of using vitamin-mineral complexes as accompanying medications. Here is presented the information on the optimal doses of vitamin and mineral supplements and recommended terms for their use.

Key words: pregnancy, pregravid preparation, vitamin and mineral complexes, folic acid, vitamin D, fetal neural tube defect.

REFERENCES

1. National Institute for Health and Care Excellence. (2014). Maternal and child nutrition (PH11) (online). Available: https://www.nice.org.uk/guidance/ph11

2. Ramakrishnan U et al. (2012). Effect of women’s nutrition before and during early pregnancy on maternal and infant outcomes: a systematic review. Paediatr Perinat Epidemiol 26(suppl 1): 285-301. https://doi.org/10.1111/j.1365-3016.2012.01281.x; PMid:22742616

3. Ramakrishnan U et al. (2012). Effect of multiple micronutrient supplementation on pregnancy and infant outcomes: a systematic review. Paediatr Perinat Epidemiol 26(suppl 1): 153-67. https://doi.org/10.1111/j.1365-3016.2012.01276.x; PMid:22742608

4. National Institute for Health and Care Excellence. (2014). Vitamin D: increasing supplement use in at-risk groups (PH56) (online). Available: http://www.nice. org.uk/guidance/ph56

5. Royal College of Obstetricians and Gynaecologists. (2014). Healthy eating and vitamin supplements in pregnancy (online). Available: https://www.rcog.org. uk/globalassets/documents/patients/patient-information-leaflets/pregnancy/ pi-healthy-eating-and-vitamin-supplements-in-pregnancy.pdf

6. Khoshnood B et al. (2015). Long term trends in prevalence of neural tube defects in Europe: population based study. BMJ 351: h5949. https://doi.org/10.1136/bmj.h5949; PMid:26601850 PMCid:PMC4658393

7. Laurence KM et al. (1981). Double-blind randomised controlled trial of folate treatment before conception to prevent recurrence of neural-tube defects. BMJ 282: 1509-12. https://doi.org/10.1136/bmj.282.6275.1509; PMid:6786536 PMCid:PMC1505459

8. MRC Vitamin Study Research Group. (1991). Prevention of neural tube defects: results of the Medical Research Council Vitamin Study. Lancet 338: 131-7. https://doi.org/10.1016/0140-6736(91)90133-A

9. Czeizel AE et al. (1992). Prevention of the first occurrence of neural-tube defects by periconceptional vitamin supplementation. N Eng J Med 327:1832-5. https://doi.org/10.1056/NEJM199212243272602; PMid:1307234

10. Berry RJ et al. (1999). Prevention of neural-tube defects with folic acid in china. N Eng J Med 341: 1485-90. https://doi.org/10.1056/NEJM199911113412001; PMid:10559448

11. Barua S et al. (2014). Folic acid supplementation in pregnancy and implications in health and disease. J Biomed Sci 21:77. M https://doi.org/10.1186/s12929-014-0077-z; PMid:25135350 PMCid:PMC4237823

12. De-Regil LM et al. (2015). Effects and safety of periconceptional oral folate supplementation for preventing birth defects. Cochrane Database Syst Rev  12. CD007950. https://doi.org/10.1002/14651858.CD007950.pub3

13. National Institute for Health and Care Excellence. (2016). Antenatal care for uncomplicated pregnancies (CG62) (online). Available: http://www.nice.org.uk/ guidance/cg62

14. Yang N et al. (2015). Effects of vitamin D supplementation during pregnancy on neonatal vitamin D and calcium concentrations: a systematic review and meta-analysis. Nutr Res 35: 547-56. https://doi.org/10.1016/j.nutres.2015.04.010; PMid:25953481

15. Scientific Advisory Committee on Nutrition. (2007). Update on vitamin D (online). Available: https://www.gov.uk/government/publications/sacn-update-onvitamin-d-2007

16. Scientific Advisory Committee on Nutrition. (2015). Draft vitamin D and health report (online). Available: https://www.gov.uk/government/uploads/system/ uploads/attachment_data/file/447402/Draft_SACN_Vitamin_D_and_Health_ Report.pdf

17. Christesen HT et al. (2012). The impact of vitamin D on pregnancy: a systematic review. Acta Obstet Gynecol Scand 9:1357-67.

18. Christesen HT et al. (2012). The impact of vitamin D in pregnancy on extraskeletal health in children: a systematic review. Acta Obstet Gynecol Scand 91:1368-80. https://doi.org/10.1111/aogs.12006; PMid:23210535

19. Thorne-Lyman A et al. (2012). Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol 26 (suppl 1): 75-90. https://doi.org/10.1111/j.1365-3016.2012.01283.x; PMid:22742603 PMCid:PMC3843348

20. Cooper C et al. (2016). Maternal gestational vitamin D supplementation and offspring bone health (MAVIDOS): a multiple, double-blind, randomised placebocontrolled trial. Lancet Diabetes Endocrinol 4:393-402.

21. Pérez-López FR et al. (2015). Effect of vitamin D supplementation during pregnancy on maternal and neonatal outcomes: a systematic review and meta-analysis of randomized controlled trials. Fertil Steril 103:1278-88. https://doi.org/10.1016/j.fertnstert.2015.02.019; PMid:25813278

22. Royal College of Obstetricians and Gynaecologists. (2014). Vitamin D in pregnancy. Available: https://www.rcog.org.uk/globalassets/documents/guidelines/ scientific-impact-papers/vitamin_d_sip43_june14.pdf

23. Poel YHM et al. (2012). Vitamin D and gestational diabetes: a systematic review and meta-analysis. Eur J Intern Med 23: 465-9. https://doi.org/10.1016/j.ejim.2012.01.007; PMid:22726378

24. Zhang MX et al. (2015). Vitamin D deficiency increases the risk of gestational diabetes mellitus: a meta-analysis of observational studies. Nutrients 7: 8366-75. https://doi.org/10.3390/nu7105398; PMid:26437429 PMCid:PMC4632418

25. Hathcock JN et al. (2007). Risk assessment for vitamin D. Am J Clin Nutr 85: 6-18. https://doi.org/10.1093/ajcn/85.1.6; PMid:17209171

26. Peña-Rosas JP et al. (2015). Daily oral iron supplementation during pregnancy. Cochrane Database Syst Rev 7: CD004736. https://doi.org/10.1002/14651858. CD004736.pub5

27. Rumbold A et al. (2015). Vitamin C supplementation in pregnancy. Cochrane Database Syst Rev 9: CD004072. https://doi.org/10.1002/14651858.CD004072.pub3.

28. Rumbold A et al. (2015). Vitamin E supplementation in pregnancy. Cochrane Database Syst Rev 9: CD004069. https://doi.org/10.1002/14651858.CD004069.pub3

29. National Institute for Health and Care Excellence. (2016). Antenatal care for uncomplicated pregnancies (CG 62) (online). Available: https://www.nice.org.uk/ guidance/cg62

30. Haider BA et al. (2015). Multiple-micronutrient supplementation for women during pregnancy. Cochrane Database Syst Rev 11: CD004905. https://doi.org/10.1002/14651858. CD004905.pub

31. Brough L. (2010). Effect of multiple-micronutrient supplementation on maternal nutrient status, infant birth weight and gestational age at birth in a lowincome, multi-ethnic population. Br J Nutr 104: 437-45. https://doi.org/10.1017/S0007114510000747; PMid:20412605

32. Czeizel AE. (2000, Nov-Dec). Primary prevention of neural-tube defects and some other major congenital abnormalities: recommendations for the appropriate use of folic acid during pregnancy. Paediatr Drugs 2(6):437-49. https://doi.org/10.2165/00128072-200002060-00003; PMid:11127844

33.  Cetin I, Berti C, Calabrese S. (2010, Jan-Feb). Role of micronutrients in the periconceptional period. Hum Reprod Update 16(1):80-95. https://doi.org/10.1093/humupd/dmp025; PMid:19567449

34.  Hanson MA, Bardsley A et al. (2015, Oct). The International Federation of Gynecology and Obstetrics (FIGO) recommendations on adolescent, preconception, and maternal nutrition: «Think Nutrition First». Int J Gynaecol Obstet. 131; 4:S213-53. https://doi.org/10.1016/S0020-7292(15)30023-0

35. Gulyaev AE. (2014). Polivitaminyi dlya beremennyih: osnovannyie na faktah dokazatelnoy meditsinyi. Voprosyi ginekologii, akusherstva i perinatologii 13; 5: 53–62. M.

36. De-Regil et al. (2015, Dec 14). Cochrane Database Syst Rev. (12):CD007950. https://doi.org/10.1002/14651858.CD007950.pub3.

37. Johansen AM, Lie RT, Wilcox AJ, Andersen LF, Drevon CA. (2008). Maternal dietary intake of vitamin A and risk of orofacial clefts: a population-based case-control study in Norway. Am J Epidemiol 167(10): 1164–70. https://doi.org/10.1093/aje/kwn035; PMid:18343877

38. Chen K, Zhang X, Wei XP, Qu P, Liu YX, Li TY. (2009). Antioxidant vitamin status during pregnancy in relation to cognitive development in the first two years of life. Early Hum Dev. 85(7): 421–7. https://doi.org/10.1016/j.earlhumdev.2009.02.001

39. Ma AG, Schouten EG, Zhang FZ, Kok FJ, Yang F et al. (2008). Retinol and riboflavin supplementation decreases the prevalence of anemia in Chinese pregnant women taking iron and folic Acid supplements. J Nutr 138(10): 1946–50. https://doi.org/10.1093/jn/138.10.1946; PMid:18806105