• Evolution of views on the etiopathogenesis of preeclampsia
en To content Full text of article

Evolution of views on the etiopathogenesis of preeclampsia

Ukrainian Journal of Perinatology and Pediatrics. 2019. 4(80): 69-74; doi 10.15574/PP.2019.80.69
Martych A. M., Yavir V. S., Spichak K. O., Sokol I. V., Hovsieiev D. O.
Bogomolets National Medical University, Kyiv, Ukraine

For citation: Martych AM, Yavir VS, Spichak KO, Sokol IV, Hovsieiev DO. (2019). Evolution of views on the etiopathogenesis of preeclampsia. Ukrainian Journal of Perinatology and Pediatrics. 4(80): 6974. doi 10.15574/PP.2019.80.69
Article received: Jul 29, 2019. Accepted for publication: Dec 12, 2019.

The study of late preeclampsia, especially preeclampsia, has been going on for many decades. The term «preeclampsia» is historically the youngest among others — toxemia, toxicosis, nephropathy, preeclampsia, late preeclampsia. However, the name change did not imply a better understanding of treatment, prevention, diagnosis and etiology. The lack of in-depth knowledge in the latter causes the imperfection of modern treatment and prevention and remains an inexhaustible source for discussion. The search for landmarks and the identification of the most important etiopathogenetic links of preeclampsia contributes to a better understanding of this pathology and the search for therapeutic and diagnostic approaches.
No conflict of interest was declared by the authors.
Key words: preeclampsia, defective implantation, myometrial junctional zone.

REFERENСES

1. Baksu A, Taskin M, Goker N, Baksu B, Uluocak A. (2006). Plasma Homocysteine in Late Pregnancies Complicated with Preeclampsia and in Newborns. American Journal of Perinatology. 23(01): 31–36. https://doi.org/10.1055/s-2005-918889; PMid:16450270

2. Bellos I, Karageorgiou V, Kapnias D, Karamanli KE, Siristatidis C. (2018). The role of interleukins in preeclampsia: A comprehensive review. Am J Reprod Immunol.80(6):e13055. https://doi.org/10.1111/aji.13055; PMid:30265415

3. Bergman L, Zetterberg H, Kaihola H, Hagberg H et al. (2018). Blood-based cerebral biomarkers in preeclampsia: Plasma concentrations of NfL, tau, S100B and NSE during pregnancy in women who later develop preeclampsia — A nested case control study. PLOS ONE. 13(5): e0196025. https://doi.org/10.1371/journal.pone.0196025; PMid:29719006 PMCid:PMC5931625

4. Boyd JD, Hamilton WJ. (1970). The human placenta. Cambridge: Heffer and Sons. https://doi.org/10.1007/978-1-349-02807-8

5. Brockelsby JC, Anthony FW, Johnson IR, Baker PN. (2000). The effects of vascular endothelial growth factor on endothelial cells: a potential role in preeclampsia. Am J Obstet Gynecol.182(1,Pt 1): 176–183. https://doi.org/10.1016/S0002-9378(00)70510-2

6. Brosens I, Derwig I, Brosens J, Fusi L et al. (2010). The enigmatic uterine junctional zone: the missing link between reproductive disorders and major obstetrical disorders? Hum Reprod. 25(3): 569—574. https://doi.org/10.1093/humrep/dep474; PMid:20085913

7. Brosens I, Dixon HG, Robertson WB. (1977). Fetal growth retardation and the arteries of the placental bed. Br J Obstet Gynaecol.84(9): 656—663. https://doi.org/10.1111/j.1471-0528.1977.tb12676.x; PMid:911717

8. Brosens I, Robertson WB, Dixon HG. (1967). The physiological response of the vessels of the placental bed to normal pregnancy. J Pathol Bacteriol. 93(2): 569—579. https://doi.org/10.1002/path.1700930218; PMid:6054057

9. Brown HK, Stoll BS, Nicosia SV et al. (1991). Uterine junctional zone: correlation between histologic findings and MR imaging. Radiology.179(2): 409—413. https://doi.org/10.1148/radiology.179.2.1707545; PMid:1707545

10. Browne JCM, Veall N. (1953). The maternal placental blood flow in normotensive and hypertensive women. J Obstet Gynaecol Br Emp.60(2): 141—147. https://doi.org/10.1111/j.1471-0528.1953.tb07668.x; PMid:13053276

11. Carin A Koelman, Audrey BC Coumans, Hans W Nijman, Ilias IN Doxiadis et al. (2000). Correlation between oral sex and a low incidence of preeclampsia: a role for soluble HLA in seminal fluid? J Reprod Immunol. 46(2): 155—166. https://doi.org/10.1016/S0165-0378(99)00062-5

12. Dekker G, Robillard PY, Roberts C. (2011). The etiology of preeclampsia: the role of the father. J Reprod Immunol. 89(2): 126—132. https://doi.org/10.1016/j.jri.2010.12.010; PMid:21529966

13. Dietl J, Honig A, Kammerer U, Rieger L. (2006). Natural killer cells and dendritic cells at the human feto-maternal interface: an effective cooperation? Placenta. 27(4—5): 341—347. https://doi.org/10.1016/j.placenta.2005.05.001; PMid:16023204

14. Dixon HG, Robertson WB. (1958). A study of the vessels of the placental bed in normotensive and hypertensive women. J Obstet Gynaecol Br Emp.65(5): 803—809. doi: https://doi.org/10.1111/j.1471-0528.1958.tb08876.x; PMid:13588440

15. Hricak H, Alpers C, Crooks LE, Sheldon PE. (1983). Magnetic resonance imaging of the female pelvis: initial experience. AJR Am J Roentgenol.141(6): 1119—1128. https://doi.org/10.2214/ajr.141.6.1119; PMid:6606306

16. Lamarca B. (2012). Endothelial dysfunction. An important mediator in the pathophysiology of hypertension during pre-eclampsia. Minerva Ginecol.64(4): 309—320.

17. Ledee N, Chaouat G, Serazin V, Lombroso R et al. (2008). Endometrial vascularity by three-dimensional power Doppler ultrasound and cytokines: a complementary approach to assess uterine receptivity. J Reprod Immunol.77: 57—62. https://doi.org/10.1016/j.jri.2007.07.006; PMid:17961712

18. Lee JK, Gersell DJ, Balfe DM, Worthington JL et al. (1985). The uterus: in vitro MR-anatomic correlation of normal and abnormal specimens. Radiology.157: 175—179. https://doi.org/10.1148/radiology.157.1.4034962; PMid:4034962

19. Leyendecker G. (2000). Redefining endometriosis: endometriosis is an entity with extreme pleiomorphism. Hum Reprod. 15: 4—7. https://doi.org/10.1093/humrep/15.1.4; PMid:10611178

20. Manaster I, Mizrahi S, Goldman-Wohl D, Sela H et al. (2008). Endometrial NK cells are special immature cells that await pregnancy. J Immunol.181: 1869—1876. https://doi.org/10.4049/jimmunol.181.3.1869; PMid:18641324

21. Marusic J, Prusac IK, Tomas SZ et al. (2013). Expression of inflammatory cytokines in placentas from pregnancies complicated with preeclampsia and HELLP syndrome. J Matem Fetal Neonatal Med.26(7): 680—685. https://doi.org/10.3109/14767058.2012.746301; PMid:23131093

22. Matsuzaki К, Harada М, Nishitani H, Matsuda T. (2005). Cerebral hyperperfusion in a patient with eclampsia with perfusion-weighted magnetic resonance imaging. Radiat Med.23(5): 376—379.

23. McCarthy S, Scott G, Majumdar S, Shapiro B et al. (1989). Uterine junctional zone: MR study of water content and relaxation properties. Radiology.171: 241—243. https://doi.org/10.1148/radiology.171.1.2928531; PMid:2928531

24. Noe M, Kunz G, Herbertz M, Mall G, Leyendecker G. (1999). The cyclic pattern of the immunocytochemical expression of oestrogen and progesterone receptors in human myometrial and endometrial layers: characterization of the endometrial-subendometrial unit. Hum Reprod.14: 190—197. https://doi.org/10.1093/humrep/14.1.190; PMid:10374119

25. Redman CW, Sargent IL. (2010). Immunology of pre-eclampsia. Am J Reprod. Immunol. 63;6: 534—543. https://doi.org/10.1111/j.1600-0897.2010.00831.x; PMid:20331588

26. Renaer M, Brosens I. (1963). Spiral arterioles in the decidua basalis in hypertensive complications of pregnancy. Ned Tijdschr Verloskd Gynaecol. 63: 103—118.

27. Richards PA, Tiltman AJ. (1995). Anatomical variation of the oestrogen receptor in normal myometrium. Virchows Arch.427: 303—307. https://doi.org/10.1007/BF00203399; PMid:7496601

28. Saito S, Sakai M, Sasaki Y, Nakashima A, Shiozaki A. (2007). Inadequate tolerance induction may induce preeclampsia. J Reprod Immunol.76: 30—39. https://doi.org/10.1016/j.jri.2007.08.002; PMid:17935792

29. Scoutt LM, Flynn SD, Luthringer DJ, McCauley TR, McCarthy SM. (1991). Junctional zone of the uterus: correlation of MR imaging and histologic examination of hysterectomy specimens. Radiology.179: 403—407. https://doi.org/10.1148/radiology.179.2.2014282; PMid:2014282

30. Werth R, Grusdew W. (1898). Untersuchungen u ber die entwicklung und morphologie der menschlichen uterusmuskulatur. Arch Gynakol. 55: 325—409. https://doi.org/10.1007/BF01981003

31. Wiczyk HP, Janus CL, Richards CJ, Graf MJ et al. (1988). Comparison of magnetic resonance imaging and ultrasound in evaluating follicular and endometrial development throughout the normal cycle. Fertil Steril.49: 969—972. https://doi.org/10.1016/S0015-0282(16)59946-4