SOVREMENNAYA PEDIATRIYA.2016.5(77):72-74; doi10.15574/SP.2016.77.72 

Evaluation of efficacy in treatment cholecalciferol asthma in children 

Tyazhka А. V., Selska Z. V.

A.A. Bogomolets National Medical University, Kiev, Ukraine

Purpose. Evaluate effectiveness of vitamin D in the treatment of asthma in children.

Materials and methods. Under our supervision there were 47 children with asthma. Among them, 11 children had persistent asthma severe, persistent asthma course of moderate severity were 26 children and persistent course of severity was mild in 10 children. Definition hidroksykaltsyferol performed using elektrochemiluminestsencysi method.

Results. Average indicator of 25(ОН)D in the blood serum of children with asthma to ingestion of vitamin D was 25.48 ng/ml (Me=25.48; Q1=18.32; Q3=32.29), and after taking a dose of cholecalciferol 2000 MO over 2 months — 36.14 nh/ml (Me=36.14; Q1=26.79; Q3=41.14). To enhance the therapeutic effect in patients with asthma was appointed higher doses of cholecalciferol — 4000 IU daily during remission and 5,000 IU daily during exacerbation rate of 2 months in the complex therapeutic measures applied in remission and exacerbation. After receiving vitamin D indicator 25(OH)D was 45.04 ng/ml (Me=45.04; Q1=42.44; Q3=60.79). In no child is determined by the level of 25(OH)D in the serum that exceeded normal values (>80 ng/ml) and clinical signs of hypervitaminosis children are not observed. After prolonged use of cholecalciferol in children with asthma was noted relief of the disease and reducing the dose of inhaled corticosteroids, used in the treatment of patients.

Conclusions. Thus this study showed that long-term use of vitamin D3 in the treatment of asthma in children contributes to the relief of the disease. Vitamin D in asthma in children is expedient to appoint all year except for the summer months.

Keywods: children, bronchial asthma, vitamin D, treatment.

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