SOVREMENNAYA PEDIATRIYA.2017.7(87):7-11; doi 10.15574/SP.2017.87.7

Nadraga O. B., Klуmenko Kh. P.
Danylo Halytsky Lviv National Medical University, Ukraine

O.B. Nadraga, Kh. P. Klуmenko

Danylo Halytsky Lviv National Medical University, Ukraine

Objective. To study the clinical particularities of infectious mononucleosis (ІМ) in the children caused by Epstein-Barr virus and coinfection of Epstein—Barr virus and cytomegalovirus.

Material and methods. The medical records of 53 inpatient children up to 5 years of age, who were treated with a diagnosis IM were analyzed. The sample included patients whose diagnosis was confirmed by serological tests.

Research results. More severe course of disease was observed in children with ІМ caused by coinfection of viruses. Patients with coinfection of viruses had higher levels of virocytes in blood and more expressed changes of some biochemical blood parameters. The CMV infection preceded EBV infecting that caused asymptomatic course of CMV infection, however this infection reactivated on a background of the immunopathological changes of macroorganism in reply to EBV infection.

Conclusions. Reactivation of CMV infection on the background of an acute EBV infection modified the course of IM in children and caused increased incidence of severe disease, however it did not affect the duration of disease and its consequences.

Key words: children, infectious mononucleosis, Epstein-Barr virus, cytomegalovirus.

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