- Epithelium-mesenchymal relations in the myometrium of women with adenomyosis, accompanied by chronic pelvic pain syndrome
Epithelium-mesenchymal relations in the myometrium of women with adenomyosis, accompanied by chronic pelvic pain syndrome
HEALTH OF WOMAN.2015.2(98):138–141; doi 10.15574/HW.2015.98.138
Epithelium-mesenchymal relations in the myometrium of women with adenomyosis, accompanied by chronic pelvic pain syndrome
Orazov M. R., Chaika A. V., Nosenko E. N.
Donetsk national medical University M. Gorky
University hospital "Center of reconstructive and restorative medicine" of Odesa national medical University
The paper presents the results of morphological studies queens obtained after hysterectomy from 60 patients with diffuse adenomyosis II–III degree, accompanied by severe chronic pelvic pain syndrome. Overall morphological evaluation sections of the uterus was performed at H & E stain. To assess the nature of intercellular cooperation various cell lines was visualized by immunohistochemistry. To study the kinetics of cell the proliferation and apoptosis were assessed cells with monoclonal antibodies Ki-67 and p53, respectively. Sensitivity to estrogens determined using monoclonal antibodies to estrogen receptors. It is concluded that the violation of adenomyosis registered epithelium-mesenchymal relations that determine a violation of branching morphogenesis uterine glands, which is accompanied by increased proliferation of epithelial cells on the background of the high sensitivity of epithelial and stromal cells to estrogens.
Key words: adenomyosis, eutopic endometrium, ectopic endometrium, morphology, Ki-67, p53, estrogen receptors.
REFERENCES
1. Дамиров М.М., Олейникова О.Н., Майорова О.В. 2013. Генитальный эндометриоз: взгляд практикующего врача: монография. М, Издательство БИНОМ: 152.
2. Носенко О.М. Клініко-морфологічна діагностика внутрішнього ендометріозу матки. Автореф. дис. канд. мед. наук: 14.01.01 «Акушерство та гінекологія». Інститут педіатрії‚ акушерства та гінекології АМН України. Київ. Б.в.‚ 1999:21.
3. Адамян Л.В., Зайратьянц О.В., Осипова А.А. и др. 2007. Роль пролиферации и апоптоза в патогенезе генитального эндометриоза. Спец. выпуск. 3-й Междунар. науч. конгр. «Новые технологии в акушерстве и гинекологии»: 123–124.
4. Сонова М.М. Клинико-морфологические, молекулярно-биологические и лечебные факторы генитального эндометриоза. Автореф. дис. канд. мед. наук: 14.00.01. ГОУ ВПО «Московский государственный медико-стоматологический университет Росздрава». Москва. Б.и., 2009:22.
5. Сорокина А.В. Патогенез, прогнозирование и постгеномная диагностика аденомиоза. Автореф. дис. канд. мед. наук: 14.01.01, 14.03.03. Российский университет дружбы народов. Москва. Б.и., 2011:39.
6. Эзимова А.С., Плескановская С.А. 2011. Критерии диагностики и прогнозирования неоплазии органов репродуктивной системы женщин. Аллергология и иммунология 12;1:83.
7. Taran F.A., Wallwiener M., Kabashi D. et al. 2012. Clinical characteristics indicating adenomyosis at the time of hysterectomy: a retrospective study in 291 patients. Arch. Gynecol. Obstet. 285;6:1571–1576. doi: 10.1007/s00404-011-2180-7. http://dx.doi.org/10.1007/s00404-011-2180-7
8. Cockerham A.Z. 2012. Adenomyosis: a challenge in clinical gynecology. J. Midwifery Womens Health. 57;3:212–220. http://dx.doi.org/10.1111/j.1542-2011.2011.00117.x; PMid:22594861
9. Fusi L., Cloke B., Brosens J.J. 2006. The uterine junctional zone. Best Pract. Res. Clin. Obstet. Gynaecol. 20;4:479–491. http://dx.doi.org/10.1016/j.bpobgyn.2006.02.001; PMid:16631411
10. Garcia L., Isaacson K. 2011. Adenomyosis: review of the literature. J. Minim. Invasive. Gynecol. 18;4:428–437. doi: 10.1016/j.jmig.2011.04.004. http://dx.doi.org/10.1016/j.jmig.2011.04.004
11. Leyendecker G., Wildt L., Mall G. 2009. The pathophysiology of endometriosis and adenomyosis: tissue injury and repair. Arch. Gynecol. Obstet. 280;4:529–538. http://dx.doi.org/10.1007/s00404-009-1191-0.