- Epilepsy in Pregnancy
Epilepsy in Pregnancy
HEALTH OF WOMAN. 2016.9(115):129–141
Epilepsy in Pregnancy
Handbook No68. June, 2016. https://www.rcog.org.uk/globalassets/documents/guidelines/green-top-guidelines/gtg68_epilepsy.pdf
REFERENCES
1. National Institute for Health and Care Excellence. The epilepsies: the diagnosis and management of the epilepsies in adults and children in primary and secondary care. NICE clinical guideline 137. Manchester. NICE. 2012.
2. Scottish Intercollegiate Guidelines Network. Diagnosis and management of epilepsy in adults: A national clinical guideline. SIGN publication no. 143. Edinburgh: SIGN. 2015.
3. Edey S, Moran N, Nashef L. 2014. SUDEP and epilepsy-related mortality in pregnancy. Epilepsia 55:e72–4. https://doi.org/10.1111/epi.12621; PMid:24754364
4. UK Epilepsy and Pregnancy Register. http://www.epilepsy andpregnancy.co.uk/. Accessed 2016, Jan 6.
5. Adab N, Chadwick DW. 2006. Management of women with epilepsy during pregnancy. The Obstetrician & Gynecologist 8:20–5. https://doi.org/10.1576/toag.8.1.020.27204
6. Knight M, Kenyon S, Brocklehurst P, Neilson J, Shakespeare J, Kurinczuk JJ (Eds.). 2014. Оn behalf of MBRRACE-UK. Saving Lives, Improving Mothers’ Care: Lessons learned to inform future maternity care from the UK and Ireland Confidential Enquiries into Maternal Deaths and. Morbidity 2009–12. Oxford: National Perinatal Epidemiology Unit. https://www.npeu.ox.ac.uk/ mbrrace-uk/reports.
7. Artama M, Auvinen A, Raudaskoski T, Isojдrvi I, Isojдrvi J. 2005. Antiepileptic drug use of women with epilepsy and congenital malformations in offspring. Neurology 64:1874–8. https://doi.org/10.1212/01.WNL.0000163771.96962.1F; PMid:15955936
8. Hernбndez-Dнaz S, Smith CR, Shen A, Mittendorf R, 26. Hauser WA, Yerby M et al. 2012. North American AED Pregnancy Registry. Comparative safety of antiepileptic drugs during pregnancy. Neurology 78:1692–9. https://doi.org/10.1212/WNL.0b013e3182574f39; PMid:22551726
9. Hernбndez-Dнaz S, Werler MM, Walker AM, Mitchell AA. 2000. Folic acid antagonists during pregnancy and the risk of birth defects. N Engl J Med 343:1608–14. https://doi.org/10.1056/NEJM200011303432204; PMid:11096168
10. Mawhinney E, Craig J, Morrow J, Russell A, Smithson WH, Parsons L et al. 2013. Levetiracetam in pregnancy: results from the UK and Ireland epilepsy and pregnancy registers. Neurology 80:400–5. https://doi.org/10.1212/WNL.0b013e31827f0874; PMid:23303847
11. Meador K, Reynolds MW, Crean S, Fahrbach K, Probst C. 2008. Pregnancy outcomes in women with epilepsy: a systematic . review and meta-analysis of published pregnancy registries and cohorts. Epilepsy Res 81:1–13. https://doi.org/10.1016/j.eplepsyres.2008.04.022; PMid:18565732 PMCid:PMC2660205
12. Morrow J, Russell A, Guthrie E, Parsons L, Robertson I, Waddell R et al. 2006. Malformation risks of antiepileptic drugs in pregnancy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 77:193–8. https://doi.org/10.1136/jnnp.2005.074203; PMid:16157661 PMCid:PMC2077578
13. Tomson T, Battino D, Bonizzoni E, Craig J, Lindhout D, Sabers A et al. 2011. EURAP study group. Dose-dependent risk of malformations with antiepileptic drugs: an analysis of data from the EURAP epilepsy and pregnancy registry. Lancet Neurol 10:609–17. https://doi.org/10.1016/S1474-4422(11)70107-7
14. Banach R, Boskovic R, Einarson T, Koren G. 2010. Long-term developmental outcome of children of women with 33. epilepsy, unexposed or exposed prenatally to antiepileptic drugs: a meta-analysis of cohort studies. Drug Saf 33:73–9. https://doi.org/10.2165/11317640-000000000-00000; PMid:20000869
15. Meador KJ, Baker GA, Browning N, Cohen MJ, Bromley RL, Clayton-Smith J et al. 2013. NEAD Study Group. Fetal antiepileptic drug exposure and cognitive outcomes at age 6 years (NEAD study): a prospective observational study. Lancet Neurol 12:244–52. https://doi.org/10.1016/S1474-4422(12)70323-X
16. Confidential Enquiry into Maternal and Child Health. Why Mothers Die 2000–2002. The Sixth Report of the Confidential Enquiries into Maternal Deaths in the United Kingdom. London: RCOG Press. 2004.
17. Centre for Maternal and Child Enquiries (CMACE). Saving Mothers’ Lives: reviewing maternal deaths to make motherhood safer: 2006–08. The Eighth Report on Confidential Enquiries into Maternal Deaths in the United Kingdom 118; 1:1–203. BJOG 2011.
18. Fisher RS, Acevedo C, Arzimanoglou A, Bogacz A, Cross JH, Elger CE et al. 2014. ILAE official report: a practical clinical definition of epilepsy. Epilepsia 55:475–82. https://doi.org/10.1111/epi.12550; PMid:24730690
19. Battino D, Tomson T, Bonizzoni E, Craig J, Lindhout D, Sabers A et al. 2013. EURAP Study Group. Seizure control and treatment changes in pregnancy: observations from the EURAP epilepsy pregnancy registry. Epilepsia 54:1621–7. https://doi.org/10.1111/epi.12302; PMid:23848605
20. Shorvon S, Tomson T. 2011. Sudden unexpected death in epilepsy. Lancet 378:2028–38. https://doi.org/10.1016/S0140-6736(11)60176-1
21. Nashef L. 1997. Sudden unexpected death in epilepsy: termi- nology and definitions. Epilepsia 38; Suppl s11:S6–8. https://doi.org/10.1111/j.1528-1157.1997.tb06130.x; PMid:19909329
22. Teramo K, Hiilesmaa V, Bardy A, Saarikoski S. 1979. Fetalheartrate during a maternal grand mal epileptic seizure. J Perinat Med 7:3–6. https://doi.org/10.1515/jpme.1979.7.1.3; PMid:106102
23. Chadwick D, Smith D. 2002. The misdiagnosis of epilepsy. BMJ 324:495–6. https://doi.org/10.1136/bmj.324.7336.495; PMid:11872532 PMCid:PMC1122430
24. Chowdhury FA, Nashef L, Elwes RD. 2008. Misdiagnosis in epilepsy: a review and recognition of diagnostic uncertainty. Eur J Neurol 15:1034–42. https://doi.org/10.1111/j.1468-1331.2008.02260.x; PMid:18717721
25. Edlow JA, Caplan LR, O’Brien K, Tibbles CD. 2013. Diagnosis of acute neurological emergencies in pregnant and post-partum women. Lancet Neurol 12:175–85. https://doi.org/10.1016/S1474-4422(13)70022-X; https://doi.org/10.1016/S1474-4422(12)70306-X
26. Enye S, Ganapathy R, Braithwaite O. 2009. Proteinuria in status epilepticus or eclampsia; a diagnostic dilemma. Am J Emerg Med 27:625.e5–6. https://doi.org/10.1016/j.ajem.2008.08.020; PMid:19497473
27. Pandey R, Garg R, Darlong V, Punj J, Khanna P. 2011. Recurrent seizures in pregnancy-epilepsy or eclampsia: a diagnostic dilemma? A case report. AANA J 79:388–90. PMid:23256267
28. Gaillard WD, Cross JH, Duncan JS, Stefan H, Theodore WH. 2011. Task Force on Practice Parameter Imaging Guidelines for the International League Against Epilepsy, Commission for Diagnostics. Epilepsy imaging study guideline criteria: commentary on diagnostic testing study guidelines and practice parameters. Epilepsia 52:1750–6. https://doi.org/10.1111/j.1528-1167.2011.03155.x; PMid:21740417 PMCid:PMC3169743
29. Dineen R, Banks A, Lenthall R. 2005. Imaging of acute neurological conditions in pregnancy and the puerperium. Clin Radiol 60:1156–70. https://doi.org/10.1016/j.crad.2005.03.010; PMid:16223612
30. ACOG Committee on Obstetric Practice.ACOG Committee Opinion. Number 299, September 2004 (replaces No. 158, September 1995). Guidelines for diagnostic imaging during pregnancy. Obstet Gynecol 104:647–51. 2004. PMid:15339791
31. Altman D, Carroli G, Duley L, Farrell B, Moodley J, Neilson J et al. 2002. Magpie Trial Collaboration Group. Do women with pre-eclampsia, and their babies, benefit from magnesium sulphate? The Magpie Trial: a randomised placebo- controlled trial. Lancet 359:1877–90. https://doi.org/10.1016/S0140-6736(02)08778-0
32. Beach RL, Kaplan PW. 2008. Seizures in pregnancy: diagnosis and management. Int Rev Neurobiol 83:259–71. https://doi.org/10.1016/S0074-7742(08)00015-9
33. Reuber M, Baker GA, Gill R, Smith DF, Chadwick DW. 2004. Failure to recognize psychogenic nonepileptic seizures may cause death. Neurology 62:834–5. https://doi.org/10.1212/01.WNL.0000113755.11398.90; PMid:15007151
34. Fairgrieve SD, Jackson M, Jonas P, Walshaw D, White K, Montgomery TL et al. 2000. Population based, prospective study of the care of women with epilepsy in pregnancy. BMJ 321:674–5. https://doi.org/10.1136/bmj.321.7262.674; PMid:10987772 PMCid:PMC27482
35. Helbig KL, Bernhardt BA, Conway LJ, Valverde KD, Helbig I, Sperling MR. 2010. Genetic risk perception and reproductive decision making among people with epilepsy. Epilepsia 51:1874–7. https://doi.org/10.1111/j.1528-1167.2009.02507.x; PMid:20163441
36. Shostak S, Ottman R. 2006. Ethical, legal, and social dimensions of epilepsy genetics. Epilepsia 47:1595–602. https://doi.org/10.1111/j.1528-1167.2006.00632.x; PMid:17054679 PMCid:PMC1802101
37. Campbell E, Kennedy F, Russell A, Smithson WH, Parsons L, 54. Morrison PJ et al. 2014. Malformation risks of antiepileptic drug monotherapies in pregnancy: updated results from the UK and Ireland Epilepsy and Pregnancy Registers. J Neurol 55. Neurosurg Psychiatry 85:1029–34. https://doi.org/10.1136/jnnp-2013-306318; PMid:24444855
38. Bromley R, Weston J, Adab N, Greenhalgh J, Sanniti A, McKay AJ et al. 2014. Treatment for epilepsy in pregnancy: neurodevelopmental outcomes in the child. Cochrane Database Syst Rev (10):CD010236. https://doi.org/10.1002/14651858.cd010236.pub2
39. Bromley RL, Mawer GE, Briggs M, Cheyne C, Clayton- Smith J, Garcнa-Fiсana M et al. 2013. Liverpool and Manchester Neurodevelopment Group. The prevalence of neuro-developmental disorders in children prenatally exposed to antiepileptic drugs. J Neurol Neurosurg Psychiatry 84:637–43. https://doi.org/10.1136/jnnp-2012-304270; PMid:23370617 PMCid:PMC4115188
40. Christensen J, Grшnborg TK, Sшrensen MJ, Schendel D, Parner ET, Pedersen LH et al. 2013. Prenatal valproate exposure and risk of autism spectrum disorders and childhood autism. JAMA 309:1696–703. https://doi.org/10.1001/jama.2013.2270; PMid:23613074 PMCid:PMC4511955
41. Shallcross R, Bromley RL, Irwin B, Bonnett LJ, Morrow J, Baker GA. 2011. Liverpool Manchester Neurodevelopment Group; UK Epilepsy and Pregnancy Register. Child development following in utero exposure: levetiracetam vs sodium valproate. Neurology 76:383–9. https://doi.org/10.1212/WNL.0b013e3182088297; PMid:21263139 PMCid:PMC3271390
42. Shallcross R, Bromley RL, Cheyne CP, Garcнa-Fiсana M, Irwin B, Morrow J et al. 2014. Liverpool and Manchester Neurodevelopment Group; UK Epilepsy and Pregnancy Register. In utero exposure to levetiracetam vs valproate: development and language at 3 years of age. Neurology 82:213–21.
43. Morrow JI, Hunt SJ, Russell AJ, Smithson WH, Parsons L, Robertson I et al. 2009. Folic acid use and major congenital malformations in offspring of women with epilepsy: a prospective study from the UK Epilepsy and Pregnancy Register. J Neurol Neurosurg Psychiatry 80:506–11. https://doi.org/10.1136/jnnp.2008.156109; PMid:18977812
44. Ogawa Y, Kaneko S, Otani K, Fukushima Y. 1991. Serum folic acid levels in epileptic mothers and their relationship to congenital malformations. Epilepsy Res 8:75–8. https://doi.org/10.1016/0920-1211(91)90039-I
45. Kaaja E, Kaaja R, Hiilesmaa V. 2003. Major malformations in offspring of women with epilepsy. Neurology 60:575–9. https://doi.org/10.1212/01.WNL.0000044157.28073.DC; PMid:12601095
46. Betts T, Fox C. 1999. Proactive pre-conception counselling for women with epilepsy – is it effective? Seizure 8:322–7. https://doi.org/10.1053/seiz.1999.0325; PMid:10512771
47. Vajda FJ, O’Brien TJ, Hitchcock A, Graham J, Cook M, Lander C et al. 2004. Critical relationship between sodium valproate dose and human teratogenicity: results of the Australian register of anti-epileptic drugs in pregnancy. J Clin Neurosci 11:854–8. https://doi.org/10.1016/j.jocn.2004.05.003; PMid:15519862
48. Vajda FJ, O’Brien TJ, Hitchcock A, Graham J, Lander C. 2003. The Australian registry of anti-epileptic drugs in pregnancy: experience after 30 months. J Clin Neurosci 10:543–9. https://doi.org/10.1016/S0967-5868(03)00158-9
49. Vajda FJ, Hitchcock A, Graham J, O’Brien T, Lander C, Eadie M. 2008. Seizure control in antiepileptic drug-treated pregnancy. Epilepsia 49:172–6. https://doi.org/10.1111/j.1528-1167.2007.01412.x; PMid:18031551
50. Gjerde IO, Strandjord RE, Ulstein M. 1988. The course of epilepsy during pregnancy: a study of 78 cases. Acta Neurol Scand 78:198–205. https://doi.org/10.1111/j.1600-0404.1988.tb03646.x; PMid:3147566
51. Tomson T, Lindbom U, Ekqvist B, Sundqvist A. 1994. Epilepsy and pregnancy: a prospective study of seizure control in 72. relation to free and total plasma concentrations of carbamazepine and phenytoin. Epilepsia 35:122–30. https://doi.org/10.1111/j.1528-1157.1994.tb02921.x; PMid:8112234
52. Boardman SG. 2013. Understanding the experiences of pregnancy in women with epilepsy. PhD dissertation. Hull: University of Hull.
53. Williams J, Myson V, Steward S, Jones G, Wilson JF, Kerr MP et al. 2002. Self-discontinuation of antiepileptic medication in pregnancy: detection by hair analysis. Epilepsia 43:824–31. https://doi.org/10.1046/j.1528-1157.2002.38601.x; PMid:12181000
54. Widnes SF, Schjшtt J, Granas AG. 2012. Risk perception and medicines information needs in pregnant women with epilepsy – a qualitative study. Seizure 21:597–602. https://doi.org/10.1016/j.seizure.2012.06.007; PMid:22762859
55. Crawford P, Hudson S. 2003. Understanding the information needs of women with epilepsy at different lifestages: results of the ‘Ideal World’ survey. Seizure 12:502–7. https://doi.org/10.1016/S1059-1311(03)00085-2
56. Nadel AS, Green JK, Holmes LB, Frigoletto FD Jr, Benacerraf BR. 1990. Absence of need for amniocentesis in patients with elevated levels of maternal serum alpha- fetoprotein and normal ultrasonographic examinations. N Engl J Med 323:557–61. https://doi.org/10.1056/NEJM199008303230901; PMid:1696358
57. Adab N. 2006. Therapeutic monitoring of antiepileptic drugs during pregnancy and in the postpartum period: is it useful CNS Drugs 20:791–800. https://doi.org/10.2165/00023210-200620100-00001; PMid:16999450
58. Pennell PB. 2003. Antiepileptic drug pharmacokinetics during pregnancy and lactation. Neurology 61;2:S35–42. https://doi.org/10.1212/WNL.61.6_suppl_2.S35; PMid:14504308
59. Pennell PB, Hovinga CA. 2008. Antiepileptic drug therapy in pregnancy I: gestation-induced effects on AED pharmacokinetics. Int Rev Neurobiol 83:227–40. https://doi.org/10.1016/S0074-7742(08)00013-5
60. Miškov S, Gjergja-Juraški R, Cvitanoviґc-Šojat L, Bakuliґc TI, Fučič A, Bošnjak-Pašiґc M et al. 2009. Prospective surveillance of Croatian pregnant women on lamotrigine monotherapy – aspects of pre-pregnancy counseling and drug monitoring. Acta Clin Croat 48:271–81. PMid:20055248
61. Harden CL, Pennell PB, Koppel BS, Hovinga CA, Gidal B, Meador KJ et al. 2009. American Academy of Neurology;American Epilepsy Society. Practice parameter update: management issues for women with epilepsy—focus on pregnancy (an evidence-based review): vitamin K, folic acid, blood levels, and breastfeeding. Neurology 73:142–9. https://doi.org/10.1212/WNL.0b013e3181a6b312; https://doi.org/10.1212/WNL.0b013e3181a6b2f8; https://doi.org/10.1212/WNL.0b013e3181a6b325; PMid:19398680 PMCid:PMC3475193
62. Pirie DA, Al Wattar BH, Pirie AM, Houston V, Siddiqua A, Doug M et al. 2014. Effects of monitoring strategies on seizures in pregnant women on lamotrigine: a meta-analysis. Eur J Obstet Gynecol Reprod Biol 172:26–31. https://doi.org/10.1016/j.ejogrb.2013.10.021; PMid:24211103
63. Perucca P, Gilliam FG. 2012. Adverse effects of antiepileptic drugs. Lancet Neurol 11:792–802. https://doi.org/10.1016/S1474-4422(12)70153-9
64. Jackson MJ, Turkington D. 2005. Depression and anxiety in epilepsy. J Neurol Neurosurg Psychiatry 76 Suppl 1:i45–7. https://doi.org/10.1136/jnnp.2004.060467; PMid:15718221 PMCid:PMC1765680
65. Park SP, Kwon SH. 2008. Cognitive effects of antiepileptic drugs. J Clin Neurol 4:99–106. https://doi.org/10.3988/jcn.2008.4.3.99; PMid:19513311 PMCid:PMC2686875
66. Viale L, Allotey J, Cheong-See F, Arroyo-Manzano D, Mccorry D, Bagary M et al. 2015. EBM CONNECT Collaboration. Epilepsy in pregnancy and reproductive outcomes: a system- atic review and meta-analysis. Lancet 386:1845–52. https://doi.org/10.1016/S0140-6736(15)00045-8
67. Malow BA. 2005. Sleep and epilepsy. Neurol Clin 23:1127–47. https://doi.org/10.1016/j.ncl.2005.07.002; PMid:16243619
68. Lamberts RJ, Thijs RD, Laffan A, Langan Y, Sander JW. 2012. Sudden unexpected death in epilepsy: people with nocturnal seizures may be at highest risk. Epilepsia 53:253–7. https://doi.org/10.1111/j.1528-1167.2011.03360.x; PMid:22192074
69. Hiilesmaa VK, Bardy A, Teramo K. 1985. Obstetric outcome in women with epilepsy. Am J Obstet Gynecol 152:499-504. https://doi.org/10.1016/0002-9378(85)90615-5
70. Hiilesmaa VK. 1992. Pregnancyandbirthin womenwithepilepsy. Neurology 42(4 Suppl 5):8–11. PMid:1574182
71. Nomura R, Bessa JF, Custуdio MG, Galletta MA, Zugaib M. 2010. P24.11: Computerized cardiotocography and Doppler velocimetry in fetuses exposed to antiepileptic drugs (abstract). Ultrasound Obstet Gynecol 36 Suppl 1:262.
72. Yamasmit W, Chaithongwongwatthana S, Tolosa JE. 2006. Prenatal vitamin K1 administration in epileptic women to prevent neonatal hemorrhage: is it effective J Reprod Med 51:463–6. PMid:16846083
73. Choulika S, Grabowski E, Holmes LB. 2004. Is antenatal vitamin K prophylaxis needed for pregnant women taking anticonvulsants? Am J Obstet Gynecol 190:882–3. https://doi.org/10.1016/j.ajog.2004.01.041; PMid:15118607
74. Kaaja E, Kaaja R, Matila R, Hiilesmaa V. 2002. Enzyme-inducing antiepileptic drugs in pregnancy and the risk of bleeding in the neonate. Neurology 58:549–53. https://doi.org/10.1212/WNL.58.4.549; PMid:11865131
75. Smith PE, Saunders J, Dawson A, Kerr MP. 1999. Intractable seizures in pregnancy. Lancet 354:1522. https://doi.org/10.1016/S0140-6736(99)09164-3
76. Patsalos PN, Frцscher W, Pisani F, van Rijn CM. 2002. The importance of drug interactions in epilepsy therapy. Epilepsia 43:365–85. https://doi.org/10.1046/j.1528-1157.2002.13001.x; PMid:11952767
77. Bardy A. 1982. Epilepsy and pregnancy: a prospective study of 154 pregnancies in epileptic women (thesis). Helsinki, Finland, University of Helsinki.
78. Pennell PB. 2006. EURAP outcomes for seizure control during pregnancy: useful and encouraging data. Epilepsy Curr 6:186–8. https://doi.org/10.1111/j.1535-7511.2006.00140.x; PMid:17260054 PMCid:PMC1783493
79. Nei M, Daly S, Liporace J. 1998. A maternal complex partial seizure in labor can affect fetal heart rate. Neurology 51:904–6. https://doi.org/10.1212/WNL.51.3.904; PMid:9748057
80. Schmidt D, Canger R, Avanzini G, Battino D, Cusi C, Beck-Mannagetta G et al. 1983. Change of seizure frequency in pregnant epileptic women. J Neurol Neurosurg Psychiatry 46:751–5. https://doi.org/10.1136/jnnp.46.8.751; PMid:6411866 PMCid:PMC1027530
81. Kevat D, Mackillop L. 2013. Neurological diseases in pregnancy. J R Coll Physicians Edinb 43:49–58. https://doi.org/10.4997/JRCPE.2013.112; PMid:23516693
82. EURAP Study Group. Seizure control and treatment in pregnancy: observations from the EURAP epilepsy pregnancy registry. Neurology. 66:354–60. 2006. https://doi.org/10.1212/01.wnl.0000195888.51845.80; PMid:16382034
83. DeLorenzo RJ, Garnett LK, Towne AR, Waterhouse EJ, Boggs JG, Morton L et al. 1999. Comparison of status epilepti- cus with prolonged seizure episodes lasting from 10 to 29 minutes. Epilepsia 40:164–9. https://doi.org/10.1111/j.1528-1157.1999.tb02070.x; PMid:9952262
84. Alldredge BK, Gelb AM, Isaacs SM, Corry MD, Allen F, Ulrich S et al. 2001. A comparison of lorazepam, diazepam, and placebo for the treatment of out-of-hospital status epilep- ticus. N Engl J Med 345:631–7. https://doi.org/10.1056/NEJMoa002141; PMid:11547716
85. McElhatton PR. 1994. The effects of benzodiazepine use during pregnancy and lactation. Reprod Toxicol 8:461–75. https://doi.org/10.1016/0890-6238(94)90029-9
86. Kuczkowski KM. 2006. Labor analgesia for the parturient with neurological disease: what does an obstetrician need to know? Arch Gynecol Obstet 274:41–6. https://doi.org/10.1007/s00404-006-0130-6; https://doi.org/10.1007/s00404-006-0137-z; https://doi.org/10.1007/s00404-006-0125-3; https://doi.org/10.1007/s00404-006-0136-0; https://doi.org/10.1007/s00404-006-0127-1; https://doi.org/10.1007/s00404-006-0126-2
87. Daroff RB, Fenichel GM, Jankovic J, Mazziotta JC. 2012. Bradley’s Neurology in Clinical Practice. 6th ed. Philadelphia: Elsevier Saunders.
88. Marinella MA. 1997. Meperidine-induced generalized seizures with normal renal function. South Med J 90:556–8. https://doi.org/10.1097/00007611-199705000-00022; PMid:9160082
89. Kuczkowski KM. 2002. Seizures on emergence from sevoflurane anaesthesia for Caesarean section in a healthy parturient. Anasthesia 57:1234–5. https://doi.org/10.1046/j.1365-2044.2002.02913_34.x
90. Hsieh SW, Lan KM, Luk HN, Jawan B. 2004. Postoperative seizures after sevoflurane anesthesia in a neonate. Acta Anasthesiol Scand 48:663. https://doi.org/10.1111/j.0001-5172.2004.0376b.x; PMid:15101868
91. Kuczkowski KM. 2004. Sevoflurane and seizures: dйjа vu. Acta Anaesthesiol Scand 48:1216.
92. Borthen I, Eide MG, Daltveit AK, Gilhus NE. 2011. Obstetric outcome in women with epilepsy: a hospital-based, retrospective study. BJOG 118:956–65. https://doi.org/10.1111/j.1471-0528.2011.03004.x; PMid:21557799
93. Thomas SV, Syam U, Devi JS. 2012. Predictors of seizures during pregnancy in women with epilepsy. Epilepsia 53:e85–8. https://doi.org/10.1111/j.1528-1167.2012.03439.x; PMid:22429269
94. Tran TA, Leppik IE, Blesi K, Sathanandan ST, Remmel R. 2002. Lamotrigine clearance during pregnancy. Neurology 59:251–5. https://doi.org/10.1212/WNL.59.2.251; PMid:12136066
95. de Haan GJ, Edelbroek P, Segers J, Engelsman M, Lindhout D, Dйvilй-Notschaele M et al. 2004. Gestation-induced changes in lamotrigine pharmacokinetics: a monotherapy study. Neurology 63:571–3. https://doi.org/10.1212/01.WNL.0000133213.10244.FD; PMid:15304599
96. Chen L, Liu F, Yoshida S, Kaneko S. 2010. Is breast-feeding of infants advisable for epileptic mothers taking antiepileptic drugs? Psychiatry Clin Neurosci 64:460–8. https://doi.org/10.1111/j.1440-1819.2010.02126.x; PMid:20923425
97. Davanzo R, Dal Bo S, Bua J, Copertino M, Zanelli E, Matarazzo L. 2013. Antiepileptic drugs and breastfeeding. Ital J Pediatr 39:50. https://doi.org/10.1186/1824-7288-39-50; PMid:23985170 PMCid:PMC3844381
98. Meador KJ, Baker GA, Browning N, Clayton-Smith J, Combs-Cantrell DT, Cohen M et al. 2010. NEAD Study Group. Effects of breastfeeding in children of women taking antiepileptic drugs. Neurology 75:1954–60. https://doi.org/10.1212/WNL.0b013e3181ffe4a9; PMid:21106960 PMCid:PMC3014232
99. Veiby G, Engelsen BA, Gilhus NE. 2013. Early child development and exposure to antiepileptic drugs prenatally and through breastfeeding: a prospective cohort study on children of women with epilepsy. JAMA Neurol 70:1367–74. https://doi.org/10.1001/jamaneurol.2013.4290; PMid:24061295
100. Turner K, Piazzini A, Franza A, Fumarola C, Chifari R, Marconi AM et al. 2006. Postpartum depression in women with epilepsy versus women without epilepsy. Epilepsy Behav 9:293–7. https://doi.org/10.1016/j.yebeh.2006.06.003; PMid:16861045
101. Galanti M, Newport DJ, Pennell PB, Titchner D, Newman M, Knight BT et al. 2009. Postpartum depression in women with epilepsy: influence of antiepileptic drugs in a prospective study. Epilepsy Behav 16:426–30. https://doi.org/10.1016/j.yebeh.2009.07.009; PMid:19854113 PMCid:PMC3589524
102. Zupanc ML. 2006. Antiepileptic drugs and hormonal contraceptives in adolescent women with epilepsy. Neurology 66(6 Suppl 3):S37–45. https://doi.org/10.1212/WNL.66.66_suppl_3.S37; PMid:16567741
103. Beghi E, Cornaggia C. 2002. RESt-1 Group. Morbidity and accidents in patients with epilepsy: results of a European cohort study. Epilepsia 43:1076–83. https://doi.org/10.1046/j.1528-1157.2002.18701.x; PMid:12199734
104. Coulam CB, Annegers JF. 1979. Do anticonvulsants reduce the efficacy of oral contraceptives? Epilepsia 20:519–25. https://doi.org/10.1111/j.1528-1157.1979.tb04834.x; PMid:477641
105. Gaffield ME, Culwell KR, Lee CR. 2011. The use of hormonal contraception among women taking anticonvulsant therapy. Contraception 83:16–29. https://doi.org/10.1016/j.contraception.2010.06.013; PMid:21134499
106. Doose DR, Wang SS, Padmanabhan M, Schwabe S, Jacobs D, Bialer M. 2003. Effect of topiramate or carbamazepine on the pharmacokinetics of an oral contraceptive containing norethindrone and ethinyl estradiol in healthy obese and nonobese female subjects. Epilepsia 44:540–9. https://doi.org/10.1046/j.1528-1157.2003.55602.x; PMid:12681003
107. Faculty of Sexual and Reproductive Healthcare. Faculty of Sexual & Reproductive Healthcare Clinical Guidance: Combined Hormonal Contraception. London: FSRH. 2011 (updated 2012).
108. Faculty of Sexual and Reproductive Healthcare. Faculty of Sexual & Reproductive Healthcare Clinical Guidance: Drug Interactions with Hormonal Contraception. London: FSRH. 2011 (updated 2012).
109. Stodieck SR, Schwenkhagen AM. 2004. Lamotrigine plasma levels and combined monophasic oral contraceptives (COC) or a contraceptive vaginal ring.A prospective evaluation in 30 women (abstract). Epilepsia 45 Suppl 7:187.
110. Wegner I, Edelbroek PM, Bulk S, Lindhout D. 2009. Lamotrigine kinetics within the menstrual cycle, after menopause, and with oral contraceptives. Neurology 73:1388–93. https://doi.org/10.1212/WNL.0b013e3181bd8295; PMid:19858461
111. World Health Organization. Medical eligibility criteria for contraceptive use. 4th ed. Geneva, WHO. 2010.
112. Faculty of Sexual and Reproductive Healthcare http:// www.fsrh.org/. Accessed 2016 Jan 06.
113. Harrison-Woolrych M, Hill R. 2005. Unintended pregnancies with the etonogestrel implant (Implanon): a case series from postmarketing experience in Australia. Contraception 71:306–8. https://doi.org/10.1016/j.contraception.2004.10.005; PMid:15792651
114. Bensouda-Grimaldi L, Jonville-Bйra AP, Beau-Salinas F, Llabres S, Autret-Leca E. 2005. Le rйseau des centres rйgionaux de pharmacovigilance. Insertion problems, removal problems, and contraception failures with Implanon®. Gynecol Obstet Fertil 33:986–90. Article in French. https://doi.org/10.1016/j.gyobfe.2005.10.016; PMid:16321557
115. Faculty of Sexual and Reproductive Healthcare Clinical Effectiveness Unit. Antiepileptic Drugs and Contraception. CEU Statement (January 2010). London, FSRH. 2010.
116. Epilepsy Action.‘An Ideal World For Women’. http://www. epilepsy.org.uk/involved/campaigns/women/ideal-world. Accessed 2016 Jan 6.
117. Driver and Vehicle Licensing Agency. Current medical guidelines: DVLA guidance for professionals – Neurological appendix. https://www.gov.uk/current-medical-guidelines- dvla-guidance-for-professionals-neurological-chapter- appendix. Accessed 2016 Jan 6.