SOVREMENNAYA PEDIATRIYA.2017.3(83):20-26; doi 10.15574/SP.2017.83.20

Mamenko M. E., Shleyenkova G. O.
Shupyk National Medical Academy of Postgraduate Education, Kyiv, Ukraine
Kharkiv Medical Academy of Postgraduate Education, Ukraine

Iodine deficiency has a negative impact on metabolism and energy, somatic growth and the formation of the nervous system structures.

Objectives. To evaluate iodine status in infants without parental care and effects of iodine supplementation on adaptation and activity of the stress-limiting system.

Material and methods. There were examined 123 children from orphanage aged from two to 3.5 months during the survey. Physical and neuropsychological development, as well as the levels of TSH, T4, T3 , serotonin, cortisol in blood serum, and urinary iodine concentration were estimated.

Results. The scanning showed that all examined children had iodine insufficiency. Median urinary iodine excretion was 56.5 μg per day [QR: 37.7; 80.5]. The optimal level of TSH (0.3-2.0 mU/L) was only in 28.8% of children. Positive linear correlation by PPMCC between TSH levels and cortisol was detected (ρ=0.189; p<0.05), as well as between TSH levels and serotonin (ρ=+0.772, р<0.05). Iodine supplementation (50 mg per day during 6 months) reduced the TSH level from 3.21 mU/L to 1.96 mU/l (pu=0.000) that normalized physical and neuropsychological development, decreased the cortisol and serotonin production to 267.0 nmol/l and 186.5 nmol/ml respectively.

Conclusions. Iodine supplementation normalizes the thyroid status in children with aggravated perinatal history, improves their adaptive capabilities and reduces the stress.

Key words: iodine, pituitary-thyroid system, serotonin, cortisol, infants.

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