HEALTH OF WOMAN. 2020.8(154): 24–29; doi 10.15574/HW.2020.154.24
Manzhura O. P.^1,2,3, Mayevskaya I. O.^2
1Kyiv City Clinical Oncology Center
²MC LLC «MedLena», Kyiv
³Bogomolets National Medical University, Kiev

The objective: to assess the efficacy and safety of using the drug Neotrizol for the treatment of bacterial vaginosis (BV) as a component of the prevention of CIN in women of reproductive age according to objective laboratory studies.

Materials and methods. The Medical Center (MC) «MedLena» conducted a prospective short-term study from April 2019 to January 2020. It included 48 patients with a diagnosis of BV at the age of 20 to 46 years. All patients underwent laboratory diagnostics of BV and treatment for 8-16 days with Neotrizol (Organosin, India). We also used pH-metry of vaginal discharge, microscopy of the urogenital smear and patient questionnaires, colposcopy and PAP test.

Results. According to the results of the study, there is an improvement in the state of the cervical epithelium after treatment. Thus, satisfactory results of colposcopy after using the drug Neotrizol were recorded in 100% of patients; aceto-white thin epithelium (characteristic of mild dysplasia and metaplasia) was observed in 37.5% of patients before treatment, and after – half as much – in 16.7% of patients; the number of treated women with a positive Schiller test increased by 27.1%. In total, 83.3% of women, after using the complex drug Neotrizol, had a normal colposcopic picture (45% of patients had an abnormal colposcopic picture before treatment). That is, an improvement in the condition of the epithelium was recorded in 38.3% of patients.

After treatment, the pH-metry of vaginal discharge returned to normal in 86.8% of patients versus 4% before therapy, which confirms the high efficacy of Neotrizol in the treatment of BV, and also contributes to a significant reduction in the time of epithelialization in the event of a destructive effect on the cervix (excision, conization, etc.) etc.).

Conclusion. It is advisable to use the drug Neotrizol (LLC Organosin) before destructive treatment of the cervix in order to accelerate healing and prevent relapse. It can be recommended for the safe and effective treatment of BV and, accordingly, for the prevention of CIN in women of reproductive age.

Keywords: bacterial vaginosis, cervical intraepithelial neoplasias, treatment, prevention, women of reproductive age, Neotrizol.

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