SOVREMENNAYA PEDIATRIYA.2019.2(98):18-22; doi 10.15574/SP.2019.98.18

Babinets L. S.
Ternopil State Medical University by I.Ya. Gorbachevsky of Ministry of Health of Ukraine

The article presents the results of the study, which proved that the couse of bronchodilatator Salbutamol and extract from the Hederis Folia, according to the proposed methodology by the authors, in the complex treatment of patients with acute respiratory disease (ARI) with acute bronchitis (AB) and bronchoobstruction is appropriate for optimization of clinical parameters, inflammation markers, parameters of humoral level immunity and complement system in connection with the higher effectiveness of this treatment program as a general.

The purpose of the study is to investigate the combined use of salbutamol and Hederis Folia extract extract for the treatment of cough with acute bronchitis in the context of acute respiratory disease with elements of bronchoconstriction.

Materials and methods. The subject of the study was 26 patients with AB in the background of ARI with broncho+obstructive syndrome. Patients with ARI and AB were divided into groups of comparison: Group I (14 patients) received a complex of GT for 7–10 days. It included antibacterial drugs (most often amoxicillin, protected aminopenicillin or macrolide in therapeutic doses), and symptomatic drugs, if necessary, nonsteroid anti-inflammatory agents (more often ibuprofen), antihistamines (most often fenspirids), vitamin C. Group II (12 patients) received a similar complex GT with a combination of salbutamol and Hederis Folia extract in the above doses for 7–10 days.

Results and conclusuons. Patients of the second group had a more pronounced positive dynamics after the elimination of the analyzed symptoms than in patients with Group I: in total from 91.7% to 10.7% and 91.4% and 30.0% of patients, respectively. This has shown a significantly higher efficiency of combined use of salbutamol and Hederis Folia extract in the complex treatment of patients with ARI. After treatment there was a significant decrease in the levels of leukocytes in peripheral blood, CRP, fibrinogen, ESR (p <0,05) in both groups. However, the efficacy of treatment in group II was significantly higher than in group I (in all indicators p<0.05), which proved the expediency of combined use of salbutamol and Hederis Folia extract in combination therapy of ARI with AB and bronchoconstriction for correction of inflammatory syndrome. Significantly, the indicators of humoral immunity in the II group decreased compared with the I group: IgG — by 6.45%, IgA — by 19.64%, IgM — by 14.75%, CIC — by 25.63%, which showed a higher efficiency. combined use of salbutamol and Hederis Folia extract in the complex treatment of patients with ARI with AB and bronchial obstruction.

Key words: acute respiratory disease, acute bronchitis, bronchoconstriction, salbutamol, Hederis Folia extract.

REFERENCES

1. Vozianova ZhI. (2008). Infektsiini i parazytarni khvoroby: u 3 t. 2-e vyd., pererob. i dop. Kyiv: Zdorovia. T.1: 884.

2. Holubovska OA (red), Andreichyn MA, Shkurba AV ta in. (2018). Infektsiini khvoroby (pidruchnyk). 2 vydannia, dopovnene i pereroblene). Kyiv: VSV Medytsyna: 688.

3. Mostovyi YuM. (red.) (2018). Suchasni klasyfikatsii ta standarty likuvannia rozpovsiudzhenykh zakhvoriuvan vnutrishnikh orhaniv. 19-e vyd., dop. i pererob. Vinnytsia: 1180.

4. Anne Meneghetti Upper Respiratory Tract Infection Updated: Jul 31, 2015 Medscape. Infectious Diseases Sections. Parasitic Infections. Chief Editor: Zab Mosenifar.

5. Butler CC et al. (2009). Variation in antibiotic prescribing and its impact on recovery in patients with acute cough in primary care: prospective study in 13 countries. BMJ. 338. https://doi.org/10.1136/bmj.b2242; PMid:19549995 PMCid:PMC3272656

6. Smith SM, Fahey T, Smucny J, Becker LA. (2014). Antibiotics for acute bronchitis. Cochrane Database of Systematic Reviews. 3, No.: CD000245. https://doi.org/10.1002/14651858.CD000245.pub3

Article received: Oct 30, 2018. Accepted for publication: Mar 02, 2019.