PERINATOLOGIYA I PEDIATRIYA. 2016.2(66):14-17; doi 10.15574/PP.2016.66.14 
 

Effective treatment of enterococcal infections of the kidneys in women with lupus nephritis in the postpartum period 
 

Limanskaya A. Yu., Davydova Yu. V., Shevchuk E. V.

SI «Institute of Pediatrics, Obstetrics and Gynecology NAMS Ukraine», Kiev 
 

Objective: to study the effectiveness of Linezolid in the treatment of lupus nephritis in women with systemic lupus erythematosus (SLE) in the postpartum period. 
 

Materials and methods. The study involved 22 women with SLE with clinical and laboratory signs of lupus nephritis of the different level of activity. All women conducted urine culture with the definition of the sensitivity of microorganisms to antibiotics. In postpartum period all women had received Linezolid antibiotic in the dosage 300 mg by intravenous administration 2 times a day for 5 days. After the treatment the control urine culture were carried out. 
 

Results. After Linezolid treatment in 100% of cases was marked the absence of significant microbial growth in urine. Also was marked the decrease of proteinuria and improvements in microscopy of urine sediment. 
 

Conclusions. The rapid development of microbial flora stability requires the use of antimicrobial drugs that are effective in the treatment of enterococcal and non-referred to already applied groups during this pregnancy. Linezolid is a highly redundant antibiotic which must be used in case of potentially intractable infections. 
 

Key words: systemic lupus erythematosus, postpartum period, enterococcal infection of the kidneys, treatment. 
 

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