Paediatric Surgery (Ukraine). 2026. 2(91): 89-98. doi: 10.15574/PS.2026.2(91).8998
Potsiurko A. R.¹, Pereyaslov A. A.^1,2, Hrymak I. Ya.¹, Ivaskevych D. Z.¹, Hyzha B. I.¹, Placko N. J.^1
1CNE of Lviv Regional Council Clinical Centre of children’s healthcare hospital «OHMATDYT», Ukraine
²SNCE «Danylo Halytsky Lviv National Medical University», Ukraine

For citation: Potsiurko AR, Pereyaslov AA, Hrymak IYa, Ivaskevych DZ, Hyzha BI, Placko NJ. (2026). Diagnostic and treatment of children with disorders of sex development. Paediatric Surgery (Ukraine). 2(91): 89-98. doi: 10.15574/PS.2026.2(91).8998.
Article received: Jan 26, 2026. Accepted for publication: Jun 15, 2026.

Disorders of sex development (DSD) is a congenital condition within which the development of chromosomal, gonadal, and anatomic sex is atypical. The clinical manifestation of DSD is variable, in some children it can be possible to diagnostic immediately after birth, but in other forms of DSD the clear diagnostic postponed to the until puberty. All this causes the difficulties in the diagnosis and treatment of patients with DSD.
Aim of this study was analyzing the results of investigation and treatment children with DSD.
Materials and methods. This study based on results of investigation and treatment of 18 patients at 2017-2025 years. In all patients, beside the typical clinical examination, the genetical investigation, determination of hormones level, and images modalities were applied.
Results. According to the results of investigation, 46,XX DSD was revealed in 8 patients; 46,XY DSD – in 7 patients: Swayer syndrome – in 5 of them, complete androgenic insensitivity syndrome – in one, and partial androgenic insensitivity syndrome – in one patient; sex chromosome DSD – in two patients, one of them had Klinefelter syndrome (47,XXY) and one – mixed gonadal dysgenesis (45,X/46,XY). Both diagnostic and therapeutic laparoscopy was performed in 11 patients. Surgery was applied in 3 patients – in all of them it was feminizing surgery was performed.
Conclusions. DSD is the challenging problem that requires rapid and complete examination to determine the patient’s gender. Patient treatment should be individualized, especially for decisions related to the future gender of the child, surgical interventions, hormone replacement therapy, and the possibility of preserving fertility.
The research was carried out in accordance with principles of the Helsinki Declaration. The informed agreement of parents was obtained for conducting the study.
The authors declare no conflict of interest.
Keywords: children, disorders of sex development, diagnostic, treatment.

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