PERINATOLOGIYA I PEDIATRIYA.2014.2(58):46-50; doi 10.15574/PP.2014.58.46 
 

Cytomorphologycal and microbiological features of the mucous membrane of the nasal cavity in children passive smokers 
 

Tyazhka O. V., Vankhanova T. O., Yaremenko L. M., Pylypenko I. F.

Department of Pediatrics number one Bogomolеts National Medical University

Road Clinical Hospital № 1 in Kyiv, Ukraine 
 

Purpose — cytomorphologycal and microbiological profile of the mucous membrane of the nose in children — passive smokers, given the degree of obtained tobacco smoke. 
 

Patients and methods. Cytomorphological and microbiological features were evaluated in nose smears from 109 children aged 1.5 to 4.5 years observed in clinic Road Hospital №1 in Kyiv. All children were thoroughly examined, with included detailed studying of the life history, complaints, presence of comorbidities, use of drugs. The survey was perfomed in the absence of the child's acute illness or exacerbation of chronic disease. 
 

Results. Children who regularly subject to exposure to tobacco smoke, had characteristic changes in the mucous membrane in the form of strained elimination mechanisms and manifested in the tendency to increased production of mucus and changes its physical and chemical composition. The violations of the rhinoepitheliocytes proportion, manifested in the ciliated cells number's reducing and goblet cells number's increase have been observed. Children whose mothers smoked were more likely to have an excess amount of Staphylococcus aureus in nasal cavity. 
 

Conclusion. The described changes of nasal mucosa are likely to be the result of tobacco toxins irritant activity that may violate the effective implementation of mucociliary clearance and reduce the protective properties of the mucous membranes, including its colonization resistance. These data help to explain the higher respiratory morbidity of children who are passive smokers. 
 

Key words: children, passive smoking, mucous membrane of the nasal cavity, microbiota. 
 

REFERENCES

1. Андреєва Т, Захожа В, Король Н, Красовський К та ін. 2010. Глобальне опитування дорослих щодо вживання тютюну (GATS). Звіт за результатами дослідження, Україна. К: 176.

2. Полька НС, Федоренко ВІ, Пластунов БА. 2013. Проблеми збереження довкілля і здоров'я нації у матеріалах XV з'їзду гігієністів України. Довкілля та здоров'я 2(65): 68—90.

3. Sisson JH, Leise LK, Smith RA et al. 1991. Acrolein induces bronchial epithelial cell ciliostasis that can be blocked by N-acetylcysteine. Am Rev Respir Dis 143: 490—495.

4. Saulyte J, Regueira C, Montes-Martinez A et al. 2014. Active or passive exposure to tobacco smoking and allergic rhinitis, allergic dermatitis, and food allergy in adults and children: a systematic review and meta;analysis. PLoS Med 11(3): e1001611.

5. Bisgaard H, Bonnelykke K. 2010. Long;term studies of the natural history of asthma in childhood. J Allergy Clin Immunol 126(2): 187—197.

6. Dempsey DA, Meyers MJ, Oh SS et al. 2012. Determination of tobacco smoke exposure by plasma cotinine levels in infants and children attending urban public hospital clinics. Arch Pediatr Adolesc Med 166(9): 851—856.

7. Zonuz AT, Rahmati A, Mortazavi H et al. 2008. Effect of cigarette smoke exposure on the growth of Streptococcus mutans and Streptococcus sanguis: an in vitro study. Nicotine Tob Res 10(1): 63—67.

8. Elwany S, Ibrahim AA, Mandour Z, Talaat I. 2012. Effect of passive smoking on the ultrastructure of the nasal mucosa in children. Laryngoscope 122(5): 965—969.

9. Garmendia J, Morey P, Bengoechea JA. 2012. Impact of cigarette smoke exposure on host-bacterial pathogen interactions. Eur Respir J 39(2): 467—477.

10. Jha P. 2012. Avoidable deaths from smoking: a global perspective. Public Health Reviews 33: 569—600.

11. Wirth N, Bohadana A, Spinosa A, Martinet Y. 2009. Les pathologies respiratoires liees au tabagisme passif. Revue des Maladies Respiratoires 26;6: 667—678.

12. Liu Y, Di YP. 2012. Effects of second hand smoke on airway secretion and mucociliary clearance. Front Physiol 3: 342.

13. Milara J, Cortijo J. 2012. Tobacco, inflammation, and respiratory tract cancer. Curr Pharm Des 18(26): 3901—3938.

14. Jensen RG, Koch A, Homoe P, Bjerregaard P. 2013. Tobacco smoke increases the risk of otitis media among Greenlandic Inuit children while exposure to organochlorines remain insignificant. Environ Int 54: 112—118.

15. Giovino GA, Mirza SA, Samet JM et al. 2012. Tobacco use in 3 billion individuals from 16 countries: an analysis of nationally representative cross-sectional household surveys. Lancet. 380(9842): 668—679.

16. Vork KL, Broadwin RL, Blaisdell RJ. 2007. Developing asthma in childhood from exposure to secondhand tobacco smoke: insights from a meta-regression. Environ Health Perspect 115(10): 1394—1400.