SOVREMENNAYA PEDIATRIYA.2019.2(98):31-34; doi 10.15574/SP.2019.98.31

Pochinok T. V., Zhuravel O. V., Chernov O. V.
Bogomolets National Medical University, Kyiv, Ukraine
SI «Institute of Pediatrics, Obstetrics and Gynecology named after academician О. Lukyanova of the National Academy of Medical Sciences of Ukraine», Kyiv

Actuality. Nitric oxide provides vasodilatation of blood vessels, regulation of microcirculation, regulation of synthesis and secretion of hormones that affect the gastrointestinal motility (gastrointestinal tract), gastric secretion. There are few studies which confirm gastroprotective effect of this mediator. In other researches signed disorders of stomach motility when blocking NO-synthase.

The aim of research — to set the level of nitric oxide and its metabolites in blood plasma and esophagus mucous membrane in children with frequent respiratory diseases (FRD) and gastroesophageal reflux disease (GERD).

Materials and methods. 150 children of puberty age were examined and divided into three groups — children with frequent respiratory diseases (FRD) and concominant gastroesophageal reflux disease (90 children, group 1), children with FRD without GERD (30 children, group 2), healthy children (30 children, group 3).

Abstract. A significant increase of total NO (29.5%) in children with RRI and GERD, NO₂ metabolite (27.4%) and NO₃ metabolite (40.2%) was established. It has been found that frequent respiratory infections accompanied with significant increase of total NO and its metabolites in esophageal mucosa — total NO — 2.16 times, NO₃ — 2.1 times, NO₂ — 1.59 times, p<0.05; however, in RRI without GERD there is no significant difference revealed. After regression analisys it was set direct linear relations between the content nitric oxide and its metabolites in esophagus mucous membrane and blood plasma. The regression between total NO level in plasma and esophagus mucous membrane was r=0.30 (p<0.05), NO₂ — r=0.29 (p<0.05), NO₃ — r=0.34 (p<0.05).

Conclusion. It was set the probable increase of nitric oxide in blood plasma and esophagus mucous membrane in GERD, positive correlation between NO and its metabolites NO₂ and NO₃ in plasma and mucous membrane.

Key words: children with recurrent respiratory infections, gastroesophageal reflux disease, nitric oxide, esophageal mucosa, blood.

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Article received: Nov 14, 2018. Accepted for publication: Mar 04, 2019.