Ukrainian Journal of Perinatology and Pediatrics. 2020. 3(83): 87-91; doi 10.15574/PP.2020.83.87
Yavir V. S., Spichak K. O., Berestovoy V. О., Martych A. M., Sokol I. V., Liashko M. B., Govsieiev D. O.
Bogomolets National Medical University, Kyiv, Ukraine
Municipal non-profit enterprise Kyiv city maternity hospital No.5, Ukraine

For citation: Yavir VS, Spichak KO, Berestovoy VО, Martych AM et al.(2020). Clinical case of effective treatment of gestational pemphigoid with intravenous immunoglobulins. Ukrainian Journal of Perinatology and Pediatrics. 3(83): 87–91. doi 10.15574/PP.2020.83.87
Article received: May 09, 2020. Accepted for publication: Sep 10, 2020.

Gestational pemphigus — is a rare autoimmune condition that manifest during pregnancy. This pathology was described for the first time in 1827 by the Karl Martius, but until now remains insufficiently studied and as a result, difficulties arise in the differential diagnosis and treatment. Clinical manifestations of the disease characterized by the appearance of a polymorphic rash on the skin and mucous membranes. In patients with impaired immune tolerance pemphigus can be complicated by hyperactivation of the immune system. To date, pregnancy is not considered as a factor that can aggravate the course of pemphigus, since during pregnancy the disease can worsen, enter into complete remission, or remain unchanged. In the literature, there is information about the manifestation of pemphigus in puerperium after rapid decrease of corticosteroid hormones in serum. The clinical course of gestational pemphigus is variable and can lead to diagnostic failures. The diagnosis usually made according to the clinic, histopathology and laboratory findings.
In this case report we describe a case of diagnosis and treatment of gestational pemphigoid, refractory to corticosteroid therapy. Clinical improvement and recovery achieved after a course of high doses of intravenous immunoglobulins.
The research was carried out in accordance with the principles of the Helsinki Declaration. The study protocol was approved by the Local Ethics Committee of these Institutes. The informed consent of the patient was obtained for conducting the studies.
No conflict of interest was declared by the authors.
Key words: pemphigoid, pregnancy, autoimmune disease, intravenous immunoglobulin.

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