- Clinical case of chronic granulomatous disease on the background of persistent eosinophilic syndrome in a child
Clinical case of chronic granulomatous disease on the background of persistent eosinophilic syndrome in a child
Modern Pediatrics. Ukraine. (2026).3(155): 165-172. doi: 10.15574/SP.2026.3(155).165172
Urbas O. V.1, Kurtash O. O.1, Vovk Z. V.1, Boyarchuk O. R.2, Holodnykh O. A.1
1Ivano-Frankivsk National Medical University, Ukraine
2Horbachevsky Ternopil National Medical University, Ukraine
For citation: Urbas OV, Kurtash OO, Vovk ZV, Boyarchuk OR, Holodnykh OA. (2026). Clinical case of chronic granulomatous disease on the background of persistent eosinophilic syndrome in a child. Modern Pediatrics. Ukraine. 3(155): 165-172. doi: 10.15574/SP.2026.3(155).165172.
Article received: Jan 02, 2026. Accepted for publication: Apr 13, 2026.
Chronic granulomatous disease (CGD) is a primary immunodeficiency (PID) characterized by impaired phagocytic function of the immune system. Persistent eosinophilic syndrome has been reported only rarely as a manifestation of CGD, as it is not considered one of the principal clinical features of the disease, although it occurs in 7-15% of patients. The rare coexistence of CGD and persistent eosinophilic syndrome underlies the uniqueness of the present clinical case.
Aim – to present a clinical case of chronic granulomatous disease that manifested for an extended period as a persistent eosinophilic syndrome, thereby complicating the early diagnosis of the underlying condition
Clinical case. A boy presented at at two months of age with recurrent bacterial infections, including suppurative axillary lymphadenitis, recurrent pneumonias, obstructive bronchitis, paraproctitis, oropharyngeal candidiasis, and eosinophilic colitis. Persistent eosinophilia was documented throughout the observation period and correlated with episodes of infectious exacerbation, and was accompanied by concomitant anemia. Despite numerous hospitalizations and extensive diagnostic investigations, the diagnosis remained elusive for a prolonged period. At the age of 2 years and 9 months, molecular genetic testing confirmed an X-linked form of CGD associated with a CYBB gene mutation. The child is currently under the care of a clinical immunologist and is being prepared for hematopoietic stem cell transplantation.
Conclusions. The combination of recurrent severe infections, persistent eosinophilia, eosinophilic colitis, and anemia should raise suspicion of an underlying primary immunodeficiency. Long-standing eosinophilic syndrome of unknown etiology requires consultation with a clinical immunologist and targeted diagnostic evaluation to exclude CGD.
The research was carried out in accordance with the principles of the Declaration of Helsinki. The informed consent of the patients was obtained for conducting the studies.
The authors declare no conflict of interest.
Keywords: clinical case, children, chronic granulomatous disease, eosinophilic syndrome, primary immunodeficiency.
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