HEALTH OF WOMAN. 2016.9(115):142–147; doi 10.15574/HW.2016.115.142 
 

Clinical aspects of medical-genetic counseling and genetic testing of twins, including those from families with family cancer syndrome

Paliychuk O. V., Polishchuk L. Z., Rossokha Z. I.

Institute of experimental pathology, Oncology and radiobiology R. Е. Kavetsky NAS of Ukraine, Kyiv

PI «Cherkasy regional Oncology center» CRC

SI «Reference-centre on molecular diagnostic MH of Ukraine», Kyiv

The cases of benign and malignant tumors development in family trees of cancer patients and in sister twins are described. The results of complex examination and medical genetic counseling of examined persons are discussed. Polymorph variants T-397C, A-351G of the gene ERS1 (СC- and GG-genotypes), genotype AG of the gene Cyp2D6 were determined that suggest the requirement for medical-genetic counseling and molecular-genetic testing for determination of gene ERS1 polymorphism in females from families with family cancer history, in particular, in twins.

Key words: family tree, proband, twins, hereditary predisposition, gene ERS1 polymorphisms.

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