HEALTH OF WOMAN. 2016.1(107):180–183; doi 10.15574/HW.2016.107.180 
 

Chromosomal abnormalities in couples with miscarriage in cycles of assisted reproductive technology 
 

Dubinina V. G., Nosenko O. M., Golovatyuk K. P., Patskova A. I.

Odessa national medical University

Medical center reproductive health «Gameta», Odessa

Center for restorative and reconstructive medicine (University hospital), Odessa 
 

The purpose of research: to evaluate the role of chromosomal abnormalities in couples in the development of miscarriage in cycles of assisted reproductive technology (ART). 
 

Material and methods. The results of the study of the karyotype couples with miscarriage after fertilization in ART cycles. Cytogenetic analysis was performed on GTG-stained metaphase plates of peripheral blood lymphocytes according to the International System of Nomenclature in human cytogenetics (ISCN 2013). 
 

Results. Abnormal karyotypes were found in 10.00% of the normal phenotype of ART patients with miscarriage, including men – to 9.17%, among women – in 10.83% of cases. The most frequent chromosomal abnormalities in patients with ART miscarriage were reciprocal and Robertsonian translocations.

Conclusion. Chromosomal abnormalities in men and women is an important factor in the loss of pregnancy after ART. Ultrasound examination should be carried out to all men and women with spouses – patients ART programs from the previous miscarriage. 
 

Key words: assisted reproductive technologies, miscarriage, karyotype, chromosomal abnormalities, peripheral blood lymphocytes. 
 

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