SOVREMENNAYA PEDIATRIYA.2016.3(75):41-43; doi10.15574/SP.2016.75.41 

Characteristics of anemic syndrome during rheumatoid arthritis in children 

Jafarova S. M.

Department of Infectious Diseases of Azerbaijan Medical University, Baku 

Anemia is frequently observed in patients with inflammatory rheumatic diseases. Depending on its severity, anemia negatively affects cardio-vascular performance, physical activity and the quality of life of patients. However, anemia is considered to be a symptom of the underlying inflammatory disease and, thus, neglected as a complex medical condition that warrants specific diagnosis and treatment. 

Key words: rheumatic diseases, anemia of chronic diseases, anemia. 

REFERENCES

1. Alekseeva EI, Bazarova TM. 2011. Yuvenilnyiy artrit: vozmozhnosti medikamentoznogo i nemedikamentoznogo lecheniya na sovremennom etape. Lechaschiy vrach. 8: 84—89.

2. Boiko YaIe. 2012. Suchasne likuvannia yuvenilnoho revmatoidnoho artrytu: era biolohichnoi terapii. Dytiachyi likar. 1—2: 14—24.

3. Vatutin NT, Kalinkina NV, Smirnova AS. 2010. Anemiya pri revmatoidnom artrite. Vestnik Harkovskogo natsionalnogo universiteta imeni V. N. Karazina. 19(898). Seriya «Meditsina».

4. Goncharik II, Malaya TV. 2013. Anemiya hronicheskih zabolevaniy. Voennaya meditsina. 3: 152—154.

5. Novikov AA, Aleksandrova EN, Karateev DE et al. 2008. Diagnosticheskoe znachenie antitel k modifitsirovannomu tsitrullinirovannomu vimentinu pri rannem revmatoidnom artrite. Klinicheskaya laboratornaya diagnostika . 8: 27—29.

6. Kaladze NN, Kabatova IN. 2013. Psihologicheskoe sostoyanie bolnyih yuvenilnyim revmatoidnyim artritom v aspekte neobhodimosti kompleksnogo mediko-psihologicheskogo soprovozhdeniya s ispolzovaniem art-terapii. Tavricheskiy mediko-biologicheskiy vestnik. 16; 3(3): 44—47.

7. Kaladze NN, Skoromnaya NN, Soboleva EM. 2010. Sostoyanie gormonalnoy regulyatsii u bolnyih yuvenilnyim revmatoidnyim artritom. Zdorove rebenka. 3: 31—57.

8. Koryakova NV. Anemii razlichnogo geneza u bolnyih revmatoidnyim artritom tema dissertatsii i avtoreferata po VAK 14.01.22. http://www.dissercat.com/content/anemii-razlichnogo-genezaub.

9. Dolgov VV, Lugovskaya SA, Morozova V, Pochtar ME. 2009. Laboratornaya diagnostika anemiy. Moskva-Tver, Triada: 148.

10. Lugovskaya SA, Kozinets GI. 2010. Gematologiya pozhilogo vozrasta. Moskva-Tver, Triada: 194.

11. Agrawal S, Misra R, Aggrawal A. 1990. Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness. Ann Rheum Dis. 2: 93-98.

12. Vreugdenhil G, Wognum AW, van Eijk HG, Swaak AJ. 1990. Anaemia in rheumatoid arthritis: the role of iron, vitamin B12, and folic acid deficiency, and erythropoietin responsiveness. Ann Rheum Dis. 2: 93—98.

13. Cario H, Smith DE, Blom H. 2011. Dihydrofolate reductase deficiency due to a homozygous DHFR mutation causes megaloblastic anemia and cerebral folate deficiency leading to severe neurologic disease. Am J Hum Genet. 88: 226—231.

14. Doyle MK, Rahman MU, Han C. 2008. Anemia in early rheumatoid arthritis is associated with interleukin 6-mediated bone marrow suppression, but has no effect on disease course or mortality. J Rheumatol. 3: 380—386.

15. Kojima S, Sasaki J, Takahashi N. 2012. Induction of hyperchromic microcytic anaemia by repeated oral administration of methotrexate in rats. J Toxicol Sci. 37: 957—968.

16. Kullich W, Niksic F, Burmucic K. 2002. Effects of the chemokine MIP—1alpha on anemia and inflammation in rheumatoid arthritis. Z Rheumatol. 61: 568—576.

17. Kuruvilla J, Leitch HA, Vickars LM. 2003. Aplastic anemia following administration of a tumor necrosis factor-alpha inhibitor. Eur J Haematol. 5: 396—398.

18. Lang F, Lang KS, Lang РА. 2006. Mechanisms and significance of eryptosis. Antioxid Redox Signal. 8: 1183—1192.

19. Libregts S, Gutierrez L, Bruin A. 2011. Chronic IFN-l production in mice induces anemia by reducing erythrocyte life span and inhibiting erythropoiesis through an IRF-1/PU.1 axis. Blood. 118: 2578—2588.

20. Means RT. 2003. Recent developments in the anemia of chronic disease. Curr Hematol Rep. 2: 116—121.

21. Michaud K, Wolfe F. 2007. Comorbidities in rheumatoid arthritis. Best practice & research Clinical rheumatology. 21(5): 885—906. http://dx.doi.org/10.1016/j.berh.2007.06.002; PMid:17870034

22. Nikolaisen C, Figenschau Y, Nossent JC. 2008. The differentiation of anaemia in rheumatoid arthritis: parameters of iron-deficiency in an Indian rheumatoid arthritis population. Rheumatol Int. 6: 507—511.

23. Peeters HR, Jongen-Lavrencic М. 1996. Course and characteristics of anaemia in patients with rheumatoid arthritis of recent onset. Ann Rheum Dis. 55 162—168.

24. Ravindran V, Jain S, Mathur DS. 2006. Anemia in rheumatoid arthritis: high prevalence of iron-deficiency anemia in Indian patients. Rheumatol Int. 12: 1091—1095.

25. Smolen JS, Landewe R, Breedveld FC. 2011. EULAR recommendations for the management of rheumatoid arthritis with synthetic and biological disease-modifying antirheumatic drugs. Ann Rheum Dis. 70: 1519.

26. Vucelic V, Stancic V, Ledinsky M. 2008. Combined megaloblastic and immunohemolytic anemia associated – a case report. Acta Clin Croat. 4: 239—243.

27. Weiss G, Schett G. 2013. Anaemia in inflammatory rheumatic diseases. Nat Rev Rheumatol. 9(4): 205—15. doi: 10.1038/nrrheum.2012.183. Epub 2012 Nov 13. http://dx.doi.org/10.1038/nrrheum.2012.183

28. Wolfe F, Michaud K. 2006. Anemia and renal function in patients with rheumatoid arthritis. J Rheumatol. 8: 1467—1468.

29. Zhu Y, Ye D, Huang Z. 2000. The correlation of cytokines TNF alpha, IFN-gamma, Epo with anemia in rheumatoid arthritis. Zhonghua Xue Ye Xue Za Zhi. 21: 587—590.