Modern Pediatrics. Ukraine. (2025).7(151): 102-107. doi: 10.15574/SP.2025.7(151).102107
Makieieva N. I.¹, Koval V. A.¹, Boldyreva O. S.², Kucherenko M. V.², Derkach A. V.^2
1Kharkiv National Medical University, Ukraine
²CNE "City Clinical Multidisciplinary Hospital No. 25" of the Kharkiv City Council, Ukraine

For citation: Makieieva NI, Koval VA, Boldyreva OS, Kucherenko MV, Derkach AV. (2025). Autoimmune hemolytic anemia and pediatric Hodgkin lymphoma: a clinical case. Modern Pediatrics. Ukraine. 7(151): 102-107. doi: 10.15574/SP.2025.7(151).102107.
Article received: May 30, 2025. Accepted for publication: Nov 09, 2025.

Autoimmune hemolytic anemia (AIHA) in combination with Hodgkin lymphoma (HL) is a rare occurrence in pediatric practice. AIHA can pose significant diagnostic challenges, masking or diverting clinical attention from the underlying oncological process.
Clinical case. This article presents a case of an 11-year-old boy diagnosed with both AIHA and HL. Initially, the patient was diagnosed with AIHA; however, further evaluation revealed the presence of HL. Standard therapy for AIHA proved to be ineffective, necessitating a change in treatment strategy. Sustained remission was achieved only after protocol-based combination chemotherapy targeting the primary oncological disease.
The article also includes a review of current scientific literature regarding the coexistence of AIHA and HL. Analysis of published clinical cases helps to better understand the pathogenetic mechanisms, diagnostic difficulties, and therapeutic approaches in such rare presentations.
Conclusions. This case emphasizes the importance of early recognition of the oncohematological nature of AIHA in pediatric patients. Further research is needed to improve our understanding of the immunopathogenesis of AIHA in the context of HL, which will support the development of better treatment strategies and improve patient outcomes.
The study was carried out according to the principles of the Declaration of Helsinki. Agreement of parents was obtained for the study.
Authors declare no conflict of interest.
Keywords: autoimmune hemolytic anemia, Hodgkin lymphoma, children, case report, autoimmune mechanisms, oncohematology.

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