• Assessment of quality of life in children with a combination of functional dyspepsia and irritable bowel syndrome
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Assessment of quality of life in children with a combination of functional dyspepsia and irritable bowel syndrome

Modern Pediatrics. Ukraine. (2023). 1(129): 23-27. doi 10.15574/SP.2023.129.23
Belousova O. Yu.1, Zimnytska T. V.2, Kazaryan L. V.1
1Kharkiv Medical Academy of Post-graduate Education, Ukraine
2V.N. Karazin Kharkiv National University, Ukraine

For citation: Belousova OYu, Zimnytska TV, Kazaryan LV. (2023). Assessment of quality of life in children with a combination of functional dyspepsia and irritable bowel syndrome. Modern Pediatrics. Ukraine. 1(129): 23-27. doi 10.15574/SP.2023.129.23.
Article received: Nov 26, 2022. Accepted for publication: Feb 07, 2023.

The prevalence of functional gastrointestinal disorders (FGID) in children ranges from 19% to 40%, depending on age. The combination of functional dyspepsia (FD) and irritable bowel syndrome (IBS) is detected in 15-44.6% of patients with FGID. Their course is characterized by more pronounced clinical symptoms: abdominal pain, which is combined with flatulence, nausea, difficulty in defecation or diarrhea, impaired stool consistency, feeling of incomplete bowel movement and deterioration in quality of life.
Purpose – to assess the quality of life in children with a combination of FD and IBS to optimize therapy.
Materials and methods. The study included 44 children with a combination FD and IBS aged 6 to 18 years (the main group). The control group consisted of 30 practically healthy children of the same age.
Diagnoses of FD and IBS were made on the basis of clinical symptoms according to the Rome criteria IV (2016). A survey of children and their parents was conducted using the international questionnaire PedsQL™ 4.0 (Pediatrics Quality of Life Inventory), which is one of the most popular questionnaires in the world, has proven to be a simple, reliable, sensitive method for studying the quality of life of healthy and sick children of different ages (2-17 years). The questionnaire has general scales, but there is a separate version of the PedsQL™4.0 Generic Core Scales, which describes physical, emotional, social, and role functioning.
Results. It was established that indicators of physical, emotional, social and school functioning and, as a result, indicators of psychosocial functioning and the overall quality of life assessment are significantly reduced in children with combined FD and IBS compared to the control group.
Conclusions. Quality of life studies are an important component of a comprehensive assessment of the overall condition of a child with comorbid FD and IBS to prevent the development of these disorders, to improve quality of life, to reduce the time and cost of assessment, and to optimize therapy.
The research was carried out in accordance with the principles of the Declaration of Helsinki. The Local Ethic Committee of the institution specified in the work adopted the study protocol. Informed consent of the children’s parents was obtained for the research.
No conflict of interests was declared by the authors.
Keywords: functional dyspepsia, irritable bowel syndrome, children, quality of life, Pediatrics Quality of Life Inventory, PedsQL™4.0 Generic Core Scales.

1. Alkhuzaei H, Almatrafi MA, Alqahtani W et al. (2022, Dec 05). Patterns of Functional Gastrointestinal Disorders Among Children in Makkah City: A Single Institutional Experience. Cureus. 14 (12): e32224. https://doi.org/10.7759/cureus.32224; PMCid:PMC9812402

2. Barberio B, Yiannakou Y, Houghton LA et al. (2022). Overlap of Rome IV Irritable Bowel Syndrome and Functional Dyspepsia and Effect on Natural History: A Longitudinal Follow-up Study. Clinical Gastroenterology and Hepatology. 20 (2): E89-E101. https://doi.org/10.1016/j.cgh.2021.04.011; PMid:33839276

3. Bouchoucha M, Deutsch D, Uong P, Mary F, Sabate J-M, Benamouzig R. (2021). Characteristics of patients with overlap functional gastrointestinal disorders. Journal of Gastroenterology and Hepatology. 36: 2171-2179. https://doi.org/10.1111/jgh.15438; PMid:33555092

4. Chen F. (2017). Management of Overlap Syndrome between Functional Dyspepsia and Irritable Bowel Syndrome by Western and Traditional Chinese Medicine. Yangtze Medicine. 1: 117-126. https://doi.org/10.4236/ym.2017.12012

5. Choi YJ, Kim N, Yoon H, Shin CM et al. (2017, Sep). Overlap between irritable bowel syndrome and functional dyspepsia including subtype analyses. J Gastroenterol Hepatol. 32 (9): 1553-1561. https://doi.org/10.1111/jgh.13756; PMid:28160607

6. Drossman DA, Hasler WL. (2016). Rome IV-Functional GI Disorders: Disorders of Gut-Brain Interaction. Gastroenterology. 150 (6): 1257-1261. https://doi.org/10.1053/j.gastro.2016.03.035; PMid:27147121

7. Edwards T, Friesen C, Schurman JV. (2018). Classification of pediatric functional gastrointestinal disorders related to abdominal pain using Rome III vs. Rome IV criterions. BMC Gastroenterology. 18: 41. https://doi.org/10.1186/s12876-018-0769-z; PMid:29549882 PMCid:PMC5857312

8. Fediv OI. (2019). Overlap-syndrom u funktsionalnii hastroenterolohii. Hastroenterolohiia. Hepatolohiia. Koloproktolohiia. Tematychnyi nomer. 1: 51]. URL: https://health-ua.com/article/41201-O.

9. Friesen CA, Schurman JV. (2018). The challenges of evolving Rome criteria for functional dyspepsia. Translational Gastroenterology and Hepatology. 3: 9. https://doi.org/10.21037/tgh.2018.09.08; PMid:30363737 PMCid:PMC6182032

10. Herasymchuk PO, Fira DB, Pavlyshyn AV. (2021). Otsinka yakosti zhyttia, poviazanoi iz zdoroviam. Visnyk medychnykh i biolohichnykh doslidzhen. 1 (7): 112-122]. https://doi.org/10.11603/bmbr.2706-6290.2021.1.11882

11. Ibrahim ATA, Hamdy AM, Elhodhod MA. (2020, Mar). Prevalence of Functional Gastrointestinal Disorders among School-aged Children and adolescents, A Multicenter Study. QJM: An International Journal of Medicine. 113; 1 (Suppl 1). https://doi.org/10.1093/qjmed/hcaa063.029

12. Jones MP, Shah A, Walker MM, Koloski NA, Holtmann G, Talley NJ. (2022). Overlap of heartburn, functional dyspepsia, and irritable bowel syndrome in a population sample: Prevalence, temporal stability, and associated comorbidities. Neurogastroenterology & Motility. 34: e14349. https://doi.org/10.1111/nmo.14349; PMid:35293084

13. Lei W-Y, Chang W-C, Wen S-H, Wong M-W et al. (2019, Apr). Impact of concomitant dyspepsia and irritable bowel syndrome on symptom burden in patients with gastroesophageal reflux disease. Journal of the Formosan Medical Association. 118; 4: 797-806. https://doi.org/10.1016/j.jfma.2018.12.002; PMid:30584006

14. Stoieva TV, Platonova OM, Dzhagiashvili OV. (2020). Overlapping Influence the Psychoemotional Profile among Children with Functional Gastrointestinal Disorders. Int J Fam Med Prim Care. 1 (5): 1025.

15. Varni JW. (2014). Encyclopedia of Quality of Life and Well-Being Research. Springer Netherlands: 4563-4563.

16. Vernon-Roberts A, Alexander I, Day AS. (2021). Systematic Review of Pediatric Functional Gastrointestinal Disorders (Rome IV Criteria). Journal of Clinical Medicine. 10 (21): 5087. https://doi.org/10.3390/jcm10215087; PMid:34768604 PMCid:PMC8585107

17. Von Wulffen M, Talley NJ, Hammer J, McMaster J et al. (2019). Overlap of irritable bowel syndrome and functional dyspepsia in the clinical setting: prevalence and risk factors. Digestive Diseases and Sciences. 64 (2): 480-486. https://doi.org/10.1007/s10620-018-5343-6; PMid:30368683

18. Zhuravlova LV. (2018). Syndrom «perekhresta» pry funktsionalnykh hastrointestynalnykh rozladakh: kompleksnyi pidkhid do likuvannia. Praktykuiuchyi likar. 7: 4.