- Anti-D-immunoprophylaxis in the outlook of the obstetrician-gynecologist
 
Anti-D-immunoprophylaxis in the outlook of the obstetrician-gynecologist
	HEALTH OF WOMAN. 2016.2(108):10–15 
	 
	Anti-D-immunoprophylaxis in the outlook of the obstetrician-gynecologist 
	 
Nazarenko L. G.
	Kharkiv medical Academy of postgraduate education, Kharkiv city clinical maternity hospital № 6 
	 
	The problem of anti-D-immunization relevant to Ukrainian medicine because, in spite of the understanding of the theoretical aspects of the prevention of hemolytic disease of the fetus and newborn, the availability of an adequate regulatory framework (quidelines of Health Care Ministry of Ukraine №№417, 626), the incidence of neonatal and perinatal losses assotiated this disease does not decrease over the years, in contrast to developed countries, where the problem of preventing sensitization D-negative women is practically solved by the introduction of programs and their resource provision. The article presents current information about the theoretical foundations and practical application of anti-D-immunization technology, proven global medicine, discussed the format and the resources needed to promote this event in the practice of ukrainian medical institutions. 
	 
	Key words: pregnancy, infant, Rhesus-conflict, immunoglobulin, prevention, sensitization. 
	 
REFERENCES
1. Pirogov VI, Schuruk NV, Malachynska MJ, Shurpyak SO On the issue of prevention of .hemolytic disease of the fetus and newborn Consilium Medicum Ukraina 8.11:4-7. /home/mainfnx/public_html/consilium-medicum.com.ua/issues.php on line 473. (in Ukrainian).
2. Ailamazyan EK, Pavlova NG. 2014. Isoimmunization pregnancy. Publishing House H-L Litres. St-Peterburge:1878. (in Russian).
3. Baryaeva OE. 1997. Isoserological incompatibility of blood between mother and fetus. ISMU Medical University of the Russian Ministry of Health. Irkutsk, ISMU: 25.
4. Mollison PL, Engelfriet CP, Contreras M. Blood Transfusion in Clinical Medicine. Chichester. UK (10 edn):318.
5. World Health Organization. Prevention of Ph-sensitization. Technical Report Series:468. 1971.
6. Urbaniak SJ, Greiss MA. 2000. Rh D haemolytic disease of the fetus and the newborn. Blood Reviews 14:44–61. http://dx.doi.org/10.1054/blre.1999.0123; PMid:10805260
7. Huchet J, Dallemagne S, Huchet C et al. 1987. Ante-partum administration of preventive treatment of Rh-D immunization in rhesus-negative women. Parallel evaluation of transplacental passage of fetal blood cells. Results of a multicentre study carried out in the Paris region. Journal de gynґecologie, obstґetrique et biologie de la reproduction 16:101–111.
8. MacKenzie IZ, Roseman F, Findlay J et al. 2006. The Kinetics of routine antenatal prophylactic intramuscular injections of polyclonal anti-D immunoglobulin. BritishJournal of Obstetrics and Gynaecology 113:97–101. http://dx.doi.org/10.1111/j.1471-0528.2005.00789.x
9. The Use of Anti-D Immunoglobulin for Rhesus D Prophylaxis.URL / Royal College of Obstetrics and Gynaecologists (RCOG Green Top Guideline 22, revised March, 2011). http://www.rcog.org.uk/files/rcogcorp/GTG22AntiD.pdf (Accessed 3/12/2013).
10. Qureshi H, Massey E, Kirwan D et al. 2014. BCSH guideline for the use of anti-D immunoglobulin for the prevention of haemolytic disease of the fetus and newborn. Transfusion Medicine 24:8-20. http://dx.doi.org/10.1111/tme.12091; PMid:25121158
11. Guidelines for the use of Rh(D) Immunoglobulin (Anti-D) in obstetrics in Australia. The Royal Australian and New Zealand College of Obstetricians and Gynaecologists. 2015, November:11.
12. Markham KB, Rossi KQ, Nagaraja HN et al. 2015. Hemolytic disease of the fetus and newborn due to multiple antibodies; Am J Obstet Gynecol. 213:68.e1-5.
13. Markelov AN. 2013. Optimization of conducting pregnant women with Rh-negative blood. Authoref. dis. kand. honey. sciences. 14.01.01. Obstetrics and Gynecology. Samara:23. (In Russian).
13. Zhou L, Thorson JA, Nugent C et al. 2005. Noninvasive prenatal RHD genotyping by real-time polymerase chain reaction using plasma from D-negative pregnant women; Am J Obstet Gynecol; 193, Issue 6:1966-1971.
14. Pilgrim H, Lloyd-Jones M, Rees A. 2009. Routine antenatal anti-D prophylaxis for Rh D negative women: a systematic review and economic evaluation. Health Technology Assessment 13:1–126. http://dx.doi.org/10.3310/hta13100
15. Croen LA, Matevia A, Yoshida CK et al. 2008. Maternal Rh D status, anti-D immune globulin exposure during pregnancy, and risk of autism spectrum disorders. Am J Obstet Gynecol. 199:234.e1-234.e6.
      
 
 
 
 
 
 