PERINATOLOGIYA AND PEDIATRIYA.2019.2(78):7-12; doi 10.15574/PP.2019.78.7

Grebinichenko G. O., Gordienko I. Y., Tarapurova O. M., Velychko A. V., Nikitchina T. V., Nosko A. O.
SI «Institute of Pediatrics, Obstetrics and Gynecology named after acad. O.M. Lukyanova NAMS of Ukraine», Kyiv

Purpose — to analyze results of complex prenatal examination of high risk pregnant women with gastroschisis in the fetus.

Patients and methods. A retrospective analysis of data on ultrasound examinations and karyotyping of 152 fetuses as patients with gastroschisis in the Department of Fetal Medicine in 2007–2018.

Results. The mean age of women was 22.6±4.35 years (range 15–35), 73.68% of them were less than 25 years old. Mean term of patients' primary referral was 23.8±7.0 weeks, the proportion of patients referred before 22 weeks of pregnancy was 53.3%. Isolated gastroschisis, without pathology of other systems and organ, was diagnosed in 87.5% of fetuses. Associated malformations were found in 12.5% of cases: structural anomalies of heart, urinary tract, musculoskeletal system, cleft lip and palate, inguinal hernia. Fetal karyotype was obtained in 83 cases (54.6%). Small for gestational age were 40.1% of fetuses with gastroschisis, polyhydramnios was present in 8.6% and olygohydramnios in 18.4% of cases. Fetal death was diagnosed in 3 cases (1.97%) in II trimester.

Conclusions. The mean term of primary referral of patients with fetal gastroschisis was unsatisfactory for timely complete examination, follow-up in dynamics, and planning the management of pregnancy. Growth restriction and olygohydramnios were the most common complications in fetuses with gastroschisis. The rate of associated structural anomalies in fetuses with gastroschisis was low, but later manifestation of some malformations is possible.

Key words: congenital diaphragmatic hernia, congenital malformations, fetal karyotype.

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Article received: Jan 21, 2019. Accepted for publication: Jun 14, 2019.