SOVREMENNAYA PEDIATRIYA.2016.8(80):129-133; doi 10.15574/SP.2016.80.129 

Allelic polymorphisms C-590T gene IL4 and C-159T gene CD14 as possible genetic markers of increased susceptibility to recurrent episodes of acute obstructive bronchitis in children

Kens O., Akopyan G., Lukyanenko N., Bergtravm V.

Institute of Hereditary Pathology AMS of Ukraine, Lviv, Ukraine

Regional Baby Clinical Hospital, Lviv, Ukraine

Objective: to search for molecular genetic markers of increased susceptibility of children to repeated episodes of acute obstructive bronchitis.

Materials and methods: 31 children of primary aged 2 to 8 years, with frequent acute respiratory infections (ARI), which are complicated by repeated episodes of acute obstructive bronchitis (GOB). For comparison of the data for children with recurrent GOB was selected a group of 35 children aged 2 to 8 years, who suffered from acute bronchitis (GB) of no more than 1–2 times a year, which was the control group results of molecular genetic studies compared 50 people with data taken by random sampling, which respectively included in a general population control group.

Results: proved that the presence of a polymorphic locus genotype Child C-590T gene IL4 increases the risk of recurrent episodes of acute obstructive bronchitis 3 times. Not registered significantly higher frequencies of genotypes CC, CT and TT polymorphic locus C-159T gene CD14.

Conclusion. In order to forecast in children genetically determined predisposition to recurrent episodes of acute obstructive bronchitis recommended to perform molecular genetic testing and CT genotypes SS polymorphic locus gene C-590T IL4.

Key words: children, recurrent episodes of acute obstructive bronchitis, acute respiratory diseases, molecular genetic analysis, gene polymorphism.

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