HEALTH OF WOMAN. 2016.1(107):50–52 
 

Algorithm diagnosis of benign uterine disease, based on immunohistochemical analysis 
 

Makarenko M. V., Govseev D. A., Gridchin S. V., Vorona R. M.

Kyiv maternity hospital № 5 
 

This article deals with the diagnosis of benign uterine diseases by immunohistochemistry.

Purpose of the research. Generate diagnostic algorithm for benign diseases of the uterus based hysteroscopic biopsy followed by immunohistochemical examination of biopsies 
 

Materials and methods. A study was conducted on 31 patients of reproductive age and postmenopausal aged 26 to 70 years. Under the proposed diagnostic algorithm performed hysteroscopic biopsy followed by immunohistochemical examination of biopsies. All women included in the study, according to the US had a suspicion of benign diseases of the uterus. According to the immunochemical study of the expression of estrogen and progesterone for convenience in practice main groups were divided into 3 groups according to the alternative principle. 
 

The research results. In a group of 31 women in the 12 cases diagnosed hyperplasia endometrium in 11 cases of endometrial polyp, 4 cases of uterine leiomyoma, chronic endometritis was found in two patients, one case of adenomyosis and one case of endometrial atrophy. 
 

The conclusions. We have formed a proprietary algorithm of diagnostic search benign diseases of the uterus based on immunohistochemistry of biopsy specimens taken during hysteroscopy. 
 

Key words: immunohistochemical studies, hysteroscopy, the level of estrogen and progesterone receptors in the endometrium. 
 

REFERENCES

1. Leyendecker G, Herbertz M, Kunz G, Mall G. 2002. Endometriosis results from the dislocation of basal endometrium. Hum. Reprod. 17:2725-2736. http://dx.doi.org/10.1093/humrep/17.10.2725; PMid:12351554

2. Bessmertnaya BC, Samoilov CF, Serebrennikov CG, Babichenko AI. 2008. Morphological and immunohistochemical features of the endometrium in women with primary and secondary infertility. Archives of Pathology 4:31-34.

3. 2002. Immunnohistochemical study expression of steroid hormone receptors in the endometrium of women during the normal menstrual cycle. Bulletin of Peoples' Friendship University, a series of Medicine. Obstetrics and gynecology. UDC 618.145-008.9-091.8. 1:55.

4. Cusick PV, Szekely CF, Beljak OV. 2014. The use of immunohistochemical studies in the diagnosis of thoracic pathologies. Ukrainian pulmonologіchny magazine. 1: addition.

5. Petrosian MA. 2007. Comparative study of progestin activity of synthetic analogs of progesterone in the experiment. The researchers note. 14;3: 45.

6. 2009. Sparing therapy combined pathology hyperplastic endo- and myometrium based on immunohistochemical analysis of steroid hormone receptors. Regular editions of "BC" 23 from 11.11.2009. 1574.