PERINATOLOGIYA I PEDIATRIYA. 2016.2(66):89-93; doi 10.15574/PP.2016.66.89 
 

Alagille Syndrome as the cause of cholestasis in infants (clinical case) 
 

Berezenko V. S., Mikhailyuk H. Z., Dyba M. B., Tkalik O. M.

Institute of Pediatrics, Obstetrics and Gynecology of NAMS of Ukraine, Kyiv, Ukraine 
 

This is the summary of literature statistics and our clinical observation of a child with Alagille syndrome. This syndrome is characterized by chronic intrahepatic cholestasis, facial dysmorphism, congenital cardio — vascular system, skeleton and eye changes, by the presence of characteristic histological criteria of morphological examination of liver biopsy and confirmed by molecular genetic studies of gene mutations or JAGGED1 NOTCH2. Diagnostic aspects of this pathology are considered. 
 

Key words: Alagille syndrome, children. 
 

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