HEALTH OF WOMAN. 2016.9(115):40–44 
 

Actual aspects of preventive strategies against the complications of late pregnancy 
 

Nazarenko L. G.

Kharkiv medical Academy of postgraduate education

The objective: of the study is investigate the possibility of effective use of progesterone support in the management of pregnancy with complications of the second half, with the signs of feto-placental dysfunction.

Patients and methods. As part of a comparative study prospectively examined 155 women with clinically outlined feto-placental pathology – IUGR I–II degree, oligohydramnios, its combination, hypoplasia of placenta, starting from 22–27 weeks. period, and 155 observational retrospective analysis of a group selected by the principle of «copy-pair». Before starting treatment with pharmacological trial was carried out to assess the potential benefits of progesterone support by investigating the effect of sublingual form of progesterone in the blood circulation in the structures of utero-placental-fetal vasculature. Evaluation criteria – the frequency of preterm birth (PR), perinatal outcomes, the dynamics of markers of endothelial dysfunction.

Results. The positive effect of the use of progesterone in PR otnoshentt frequency in women with late pregnancy complications associated with feto-placental dysfunction. The positive trends of perinatal mortality .Issledovanie endotelialnoy dysfunction markers allowed to establish a positive trend vascular adaptation under the influence of progesterone, which is a unique positive aspect, which indirectly explains the best pregnancy outcomes for the fetus, reducing the number of children with weight <2500 g, that is an argument in favor the prospects of clinical application of progesterone support in the current conditions to reduce the frequency of complications of second half of pregnancy and adverse perinatal outcomes.

Conclusions. The positive effect of the use of progesterone in the incidence of late complications of pregnancy associated with feto-placental dysfunction, manifested significantly lower percentage ol primarily clinically important component PR to 34 week period which affects the quality of the health and viability of an unborn child. The introduction of a pharmacological test with progesterone to determine the appropriateness of the destination in the treatment of foreign exchange progesterone support, and therefore deserves ,, use in clinical practice.

Key words: progestern, sublingual form, prenatal, pregnancy, Luteine.

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