SOVREMENNAYA PEDIATRIYA.2016.5(77):112-118; doi10.15574/SP.2016.77.112 

Report on post-marketing study of the efficacy and safety of dietary supplements to the diet «Tsunami» in the program of treatment and prevention of asymptomatic leucocyturia and bacteriuria in children 

Ovcharenko L. S., Vertegel A. A.
SI «Zaporizhzhia Medical Academy of Postgraduate Education of Ukraine»

The results of open comparative randomized clinical examination on study of the efficacy and safety of «Tsunami» preparation containing dry concentrate juice and extract of Vaccinium macrocarpon, in children in the age 3 to 7 years are shown. It is shown that the dietary supplement is effective in the prevention and treatment of asymptomatic leucocyturia and bacteriuria in children.

Key words: asymptomatic leucocyturia and bacteriuria, children, treatment, prevention, dietary supplement, Vaccinium macrocarpon.

REFERENCES

1. Syichev DA. 2011. Primenenie preparatov klyukvyi v urologicheskoy praktike: vzglyad klinicheskogo farmakologa. Urologiya. 2: 44—49.

2. Ipe DS, Sundac L, Benjamin JrWH et al. 2013. Asymptomatic bacteriuria: prevalence rates of causal microorganisms, etiology of infection in different patient populations, and recent advances in molecular detection. FEMS Microbiol Lett. 346: 1—10. http://dx.doi.org/10.1111/1574-6968.12204; PMid:23808987

3. Brandstrom P, Hansson S. 2015. Long-term, low-dose prophylaxis against urinary tract infections in young children. Pediatric Nephrology. 30(3): 425—432. http://dx.doi.org/10.1007/s00467-014-2854-z; PMid:24906665

4. Blumberg JB, Camesano TA, Cassidy A et al. 2013. Cranberries and Their Bioactive Constituents in Human Health. Adv Nutr. 4: 618—632. http://dx.doi.org/10.3945/an.113.004473; PMid:24228191 PMCid:PMC3823508

5. Afshar K, Stothers L, Scott H, MacNeily AE. 2012. Cranberry juice for prevention of pediatric urinary tract infection: a randomized controlled trial. J Urol. 188: 1584-1587. http://dx.doi.org/10.1016/j.juro.2012.02.031; PMid:22910239

6. Salo J, Uhari M, Helminen M et al. 2012. Cranberry juice for the prevention of recurrences of urinary tract infections in children: a randomized placebo-controlled trial. Clin Infect Dis. 54(3): 340—346. http://dx.doi.org/10.1093/cid/cir801; PMid:22100577

7. Hajar F, Taleb M, Aoun B, Shatila A. 2011. Dipstick urine analysis screening among asymptomatic school children. N Am J Med Sci. 3(4): 179—184. http://dx.doi.org/10.4297/najms.2011.3179; PMid:22540088 PMCid:PMC3336909

8. Howell AB, Botto H, Combescure C et al. 2010. Dosage effect on uropathogenic Escherichia coli anti-adhesion activity in urine following consumption of cranberry powder standardized for proanthocyanidin content: a multicentric randomized double blind study. BMC Infectious Diseases. 10: 9—14. http://dx.doi.org/10.1186/1471-2334-10-94; PMid:20398248 PMCid:PMC2873556

9. Fernandez-Puentes V, Uberos J, Rodriguez-Belmonte R et al. 2015. Efficacy and safety profile of cranberry in infants and children with recurrent urinary tract infection. Anales de Pediatria (English Edition). 82(6): 397—403. http://dx.doi.org/10.1016/j.anpede.2015.05.007

10. Dang LNN, Doan TLB, Doan NH et al. 2013. Epidemiological urinalysis of children from kindergartens of Can Gio, Ho Chi Minh City — Vietnam. BMC. Pediatrics. 13: 183. http://dx.doi.org/10.1186/1471-2431-13-183; PMid:24206763 PMCid:PMC3829665

11. Goldman R. D. Cranberry juice for urinary tract infection in children / R. D. Goldman // Canadian Family Physician. — 2012. — Vol. 58. — P. 398—400.

12. Jepson R. G. Cranberries for preventing urinary tract infections / R. G. Jepson, G. Williams, J. C. Craig // Cochrane Database Syst. Rev. — 2012. — Vol. 10. — CD001321.

13. Liska D. A. Cranberries and Urinary Tract Infection (UTI): Assessment of the Evidence / D. A. Liska, K. Maki1 // The FASEB Journal. — 2015. — Vol. 29 (1). — P. 912—922.

14. El-Abden MYZ, Abo-ElKheir OI, El-Sadek SM et al. 2013. Screening of renal diseases by urine analysis in primary school aged children at El-Gharbiya governorate-Egypt. The Egyptian Journal of Hospital Medicine. 50: 24—33. http://dx.doi.org/10.12816/0000822

15. Utsch B, Klaus G. 2014. Urinalysis in children and adolescents. Dtsch Arztebl Int. 111: 617-626. PMid:25283761 PMCid:PMC4187024

16. Vijayakumar M. 2012. Management of urinary tract infection. Indian Journal of Practical Pediatrics. 14(1): 40—48.